130 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
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Article Title
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Scaffold Repurposing of Nucleosides (Adenosine Receptor Agonists): Enhanced Activity at the Human Dopamine and Norepinephrine Sodium Symporters.
National Institute of Diabetes and Digestive and Kidney Diseases
Norbenzomorphan Scaffold: Chemical Tool for Modulating Sigma Receptor-Subtype Selectivity.
The University of Texas At Austin
2-Amino-5-arylethynyl-thiophen-3-yl-(phenyl)methanones as A
National Institute of Diabetes and Digestive and Kidney Disease
Indazole as a Phenol Bioisostere: Structure-Affinity Relationships of GluN2B-Selective NMDA Receptor Antagonists.
University Munster
2,6-diazaspiro[3.4]octan-7-one derivatives as potent sigma-1 receptor antagonists that enhanced the antinociceptive effect of morphine and rescued morphine tolerance.
Xuzhou Medical University
2-Phenylcyclopropylmethylamine (PCPMA) as a privileged scaffold for central nervous system drug design.
Shanghaitech University
Alicyclic Ring Size Variation of 4-Phenyl-2-naphthoic Acid Derivatives as P2Y
National Institute of Diabetes and Digestive and Kidney Diseases
Novel S1R agonists counteracting NMDA excitotoxicity and oxidative stress: A step forward in the discovery of neuroprotective agents.
University of Pavia
Discovery and computational studies of piperidine/piperazine-based compounds endowed with sigma receptor affinity.
University of Messina
Discovery of AD258 as a Sigma Receptor Ligand with Potent Antiallodynic Activity.
Universit£
What We Have Gained from Ibogaine: α3β4 Nicotinic Acetylcholine Receptor Inhibitors as Treatments for Substance Use Disorders.
University of Illinois At Chicago
Pharmacology and Therapeutic Potential of Benzothiazole Analogues for Cocaine Use Disorder.
High Point University
Design and Synthesis of Orally Active Quinolyl Pyrazinamides as Sigma 2 Receptor Ligands for the Treatment of Pancreatic Cancer.
University of Michigan
Benzomorphan skeleton, a versatile scaffold for different targets: A comprehensive review.
University of Catania
From dopamine 4 to sigma 1: Synthesis, SAR and biological characterization of a piperidine scaffold of σ1 modulators.
University of Nebraska Medical Center
Synthesis and pharmacological characterization of multiply substituted 2H-chromene derivatives as P2Y
National Institute of Diabetes and Digestive and Kidney Diseases
Discovery and Optimization of Pyrrolopyrimidine Derivatives as Selective Disruptors of the Perinucleolar Compartment, a Marker of Tumor Progression toward Metastasis.
University of Kansas
Discovery and Characterization of the First Nonpeptide Antagonists for the Relaxin-3/RXFP3 System.
Research Triangle Institute
Preparation of novel analogs of 2-arylpiperidines and evaluation of their sigma receptor binding affinities.
University of Texas At Austin
Synthesis of 8-aminomorphans with high KOR affinity.
Institut F£R Pharmazeutische Und Medizinische Chemie Der Universit£T M£Nster
Dual Sigma-1 receptor antagonists and hydrogen sulfide-releasing compounds for pain treatment: Design, synthesis, and pharmacological evaluation.
University of Catania
Synthesis and biological evaluation of conformationally restricted GluN2B ligands derived from eliprodil.
Westf£Lische Wilhelms-Universit£T M£Nster
Discovery of Potent Cholinesterase Inhibition-Based Multi-Target-Directed Lead Compounds for Synaptoprotection in Alzheimer's Disease.
Yeditepe University
Design, synthesis and biological evaluation of novel aminopropylcarboxamide derivatives as sigma ligands.
University of Trieste
Research progress in biological activities of isochroman derivatives.
Shaanxi University of Chinese Medicine
Benzylaminofentanyl derivates: Discovery of bifunctional μ opioid and σ
Jiangsu Ocean University
Positron Emission Tomography (PET) Imaging Tracers for Serotonin Receptors.
Beijing Normal University
Development of tumor-targeting aza-vesamicol derivatives with high affinity for sigma receptors for cancer theranostics.
Kanazawa University
Structure-Activity Studies of 1
National Institute of Diabetes and Digestive and Kidney Diseases
Development of novel phenoxyalkylpiperidines as high-affinity Sigma-1 (σ
University of Bari Aldo Moro
Bridged Piperidine Analogues of a High Affinity Naphthalene-Based P2Y
National Institute of Diabetes and Digestive and Kidney Diseases
Fluoroalkylation of Dextromethorphan Improves CNS Exposure and Metabolic Stability.
The University of Kansas
Discovery of Investigational Drug CT1812, an Antagonist of the Sigma-2 Receptor Complex for Alzheimer's Disease.
Cognition Therapeutics
Chemoenzymatic synthesis of 2,6-disubstituted tetrahydropyrans with high σ
Westf£Lische Wilhelms-Universit£T M£Nster
Structure-Activity Relationship of Heterocyclic P2Y
National Institute of Diabetes and Digestive and Kidney Diseases
Novel Sigma 1 Receptor Antagonists as Potential Therapeutics for Pain Management.
The State University of New Jersey
Synthesis, binding, and functional properties of tetrahydroisoquinolino-2-alkyl phenones as selective σ
Guangdong Medical University
Small Molecules Selectively Targeting Sigma-1 Receptor for the Treatment of Neurological Diseases.
Soochow University
Ifenprodil Stereoisomers: Synthesis, Absolute Configuration, and Correlation with Biological Activity.
Westf£Lische Wilhelms-Universit£T M£Nster
Negative allosteric modulators of the GluN2B NMDA receptor with phenylethylamine structure embedded in ring-expanded and ring-contracted scaffolds.
Institut F£R Pharmazeutische Und Medizinische Chemie Der Universit£T M£Nster
Sigma-1 and Sigma-2 Receptor Modulators as Potential Therapeutics for Alzheimer's Disease.
Usona Institute
Fluorinated 2-Arylcyclopropan-1-amines - A new class of sigma receptor ligands.
Universit£T M£Nster
Novel Dithiolane-Based Ligands Combining Sigma and NMDA Receptor Interactions as Potential Neuroprotective Agents.
University of Modena and Reggio Emilia
Sigma Receptor Ligands Carrying a Nitric Oxide Donor Nitrate Moiety: Synthesis, In Silico, and Biological Evaluation.
University of Catania
Synthesis, Cytotoxicity Evaluation, and Computational Insights of Novel 1,4-Diazepane-Based Sigma Ligands.
University of Trieste
Isolation and Synthesis of Veranamine, an Antidepressant Lead from the Marine Sponge
University of Mississippi
Thiophene bioisosteres of GluN2B selective NMDA receptor antagonists: Synthesis and pharmacological evaluation of [7]annuleno[b]thiophen-6-amines.
Westf£Lische Wilhelms-Universit£T M£Nster
Structure-Based Design of 3-(4-Aryl-1H-1,2,3-triazol-1-yl)-Biphenyl Derivatives as P2Y14 Receptor Antagonists.
National Institute of Diabetes and Digestive and Kidney Diseases
Development of Novel Alkoxyisoxazoles as Sigma-1 Receptor Antagonists with Antinociceptive Efficacy.
East China Normal University
Synthesis of spiro-2,6-dioxopiperazine and spiro-2,6-dioxopyrazine scaffolds using amino acids in a three-component reaction to generate potential Sigma-1 (σ
Memorial Sloan Kettering Cancer Center
Discovery, Optimization, and Characterization of ML417: A Novel and Highly Selective D
National Institute of Neurological Disorders and Stroke
Truncated (N)-Methanocarba Nucleosides as Partial Agonists at Mouse and Human A
Medical College of Wisconsin
Tetrahydro-3-benzazepines with fluorinated side chains as NMDA and σ
Institut F£R Pharmazeutische Und Medizinische Chemie Der Universit£T M£Nster
Synthesis, in vitro and in vivo characterization of new benzoxazole and benzothiazole-based sigma receptor ligands.
University of Catania
Discovery of a novel class of potent and selective tetrahydroindazole-based sigma-1 receptor ligands.
Northwestern University
Synthesis and Structure-Affinity Relationships of Spirocyclic Benzopyrans with Exocyclic Amino Moiety.
Universit£T M£Nster
Development of Novel Quinoxaline-Based κ-Opioid Receptor Agonists for the Treatment of Neuroinflammation.
Universit£T M£Nster
Modification of the 4-phenylbutyl side chain of potent 3-benzazepine-based GluN2B receptor antagonists.
Institut F£R Pharmazeutische Und Medizinische Chemie Der Universit£T M£Nster
Impact of hydroxy moieties at the benzo[7]annulene ring system of GluN2B ligands: Design, synthesis and biological evaluation.
Institut F£R Pharmazeutische Und Medizinische Chemie Der Universit£T M£Nster
3-Amino-chromanes and Tetrahydroquinolines as Selective 5-HT
University of Minnesota Twin Cities
Discovery of new potent dual sigma receptor/GluN2b ligands with antioxidant property as neuroprotective agents.
University of Trieste
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.
Qbi Covid-19 Research Group (Qcrg)
Pyridine bioisosteres of potent GluN2B subunit containing NMDA receptor antagonists with benzo[7]annulene scaffold.
Institut F£R Pharmazeutische Und Medizinische Chemie Der Westf£Lischen Wilhelms-Universit£T M£Nster
Neurogenic and neuroprotective donepezil-flavonoid hybrids with sigma-1 affinity and inhibition of key enzymes in Alzheimer's disease.
IQM-CSIC
Identification of dual Sigma1 receptor modulators/acetylcholinesterase inhibitors with antioxidant and neurotrophic properties, as neuroprotective agents.
University of Pavia
New piperidine-based derivatives as sigma receptor ligands. Synthesis and pharmacological evaluation.
University of Trieste
Hydroxymethyl bioisosteres of phenolic GluN2B-selective NMDA receptor antagonists: Design, synthesis and pharmacological evaluation.
Institut F£R Pharmazeutische Und Medizinische Chemie Der Universit£T M£Nster
Multifunctional thiosemicarbazones and deconstructed analogues as a strategy to study the involvement of metal chelation, Sigma-2 (σ
University of Bari Aldo Moro
Quest for Novel Chemical Entities through Incorporation of Silicon in Drug Scaffolds.
Csir-National Chemical Laboratory
Synthesis of 3-aza[4.4.3]propellanes with high σ
Institut F£R Pharmazeutische Und Medizinische Chemie Der Westf£Lischen Wilhelms-Universit£T M£Nster
Indole in the target-based design of anticancer agents: A versatile scaffold with diverse mechanisms.
Mazandaran University of Medical Sciences
Deconstruction - reconstruction approach to analyze the essential structural elements of tetrahydro-3-benzazepine-based antagonists of GluN2B subunit containing NMDA receptors.
Institut F£R Pharmazeutische Und Medizinische Chemie Der Westf£Lischen Wilhelms-Universit£T M£Nster
Structure-Guided Modification of Heterocyclic Antagonists of the P2Y
National Institute of Diabetes and Digestive and Kidney Diseases
2-Methyltetrahydro-3-benzazepin-1-ols - The missing link in SAR of GluN2B selective NMDA receptor antagonists.
Institut F£R Pharmazeutische Und Medizinische Chemie Der Westf£Lischen Wilhelms-Universit£T M£Nster
Synthesis, Receptor Affinity, and Antiallodynic Activity of Spirocyclic σ Receptor Ligands with Exocyclic Amino Moiety.
Universit£T M£Nster
Investigating isoindoline, tetrahydroisoquinoline, and tetrahydrobenzazepine scaffolds for their sigma receptor binding properties.
University of Texas At Austin
Synthesis and pharmacological evaluation of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives as sigma-2 receptor ligands.
Guangdong Medical University
Contilisant, a Tetratarget Small Molecule for Alzheimer's Disease Therapy Combining Cholinesterase, Monoamine Oxidase Inhibition, and H3R Antagonism with S1R Agonism Profile.
Iqog, Csic
Synthesis and pharmacological evaluation of benzamide derivatives as potent and selective sigma-1 protein ligands.
Universities of Lille
Chiral-pool synthesis of 1,2,4-trisubstituted 1,4-diazepanes as novelσ
Institut F£R Pharmazeutische Und Medizinische Chemie Der Universit£T M£Nster
Do spiroindolines have the potential to replace vesamicol as lead compound for the development of radioligands targeting the vesicular acetylcholine transporter?
Helmholtz-Zentrum Dresden-Rossendorf
Synthesis of conformationally restricted 1,3-dioxanes to analyze the bioactive conformation of 1,3-dioxane-basedσ
Institut F£R Pharmazeutische Und Medizinische Chemie Der Westf£Lischen Wilhelms-Universit£T M£Nster
Lipase-catalyzed kinetic resolution as key step in the synthesis of enantiomerically pureσ ligands with 2-benzopyran structure.
Universit£T M£Nster
Novel Sigma Receptor Ligand-Nitric Oxide Photodonors: Molecular Hybrids for Double-Targeted Antiproliferative Effect.
University of Catania
Reevaluation of fenpropimorph as aσ receptor ligand: Structure-affinity relationship studies at humanσ
Virginia Commonwealth University
SPIROCYCLIC MODULATORS OF CHOLESTEROL BIOSYNTHESIS AND THEIR USE FOR PROMOTING REMYELINATION
Genentech
A CLASS OF FUSED RING COMPOUNDS, AND PREPARATION AND USE THEREOF
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)
N-AROMATIC AMIDE COMPOUNDS, PREPARATION METHODS AND USES THEREOF
Shenzhen Edk Pharmaceutical Technology
Indole derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2
Merck Sharp & Dohme
Use of physiological cooling active ingredients, and agents containing such active ingredients
Symrise
Oxazetidine derivatives, process for preparing them and use in human medicine and in cosmetics
Galderma Research & Development
Optimization of a direct spectrophotometric method to investigate the kinetics and inhibition of sialidases.
Universit�� Degli Studi Di Siena
Highly Potent Cell-Permeable and Impermeable NanoLuc Luciferase Inhibitors.
Promega Biosciences
Tetracyclic heterocycle compounds and methods of use thereof for the treatment of viral diseases
Merck Sharp & Dohme
Inhibition of WDR5 interaction with its binding partners
The Regents of The University of Michigan