Compile Data Set for Download or QSAR
Report error Found 53 Enz. Inhib. hit(s) with all data for entry = 50019330
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50618171(CHEMBL5429504)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at alpha7 nAChRs in human SH-SY5Y cells assessed as increase in intracellular calcium level by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50618170(CHEMBL5416144)
Affinity DataIC50: 28nMAssay Description:Inhibition of alpha3beta4 nAChRs (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50534287(CHEMBL4519018)
Affinity DataIC50: 30nMAssay Description:Antagonist activity at alpha3beta4 nAChR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50618166(CHEMBL5401803)
Affinity DataIC50: 33nMAssay Description:Antagonist activity at rat alpha3beta2 nACh receptor expressed in Xenopus oocyte by voltage-clamp based electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50534287(CHEMBL4519018)
Affinity DataIC50: 84nMAssay Description:Antagonist activity at sigma 1 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50618166(CHEMBL5401803)
Affinity DataIC50: 97nMAssay Description:Antagonist activity at rat alpha3beta4 nACh receptor expressed in Xenopus oocyte by voltage-clamp based electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50618166(CHEMBL5401803)
Affinity DataIC50: 103nMAssay Description:Antagonist activity at human alpha7 nACh receptor expressed in Xenopus oocyte by voltage-clamp based electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50534293(CHEMBL3341966)
Affinity DataIC50: 110nMAssay Description:Partial agonist activity at alpha4beta2 nAChR in HEK293 cells assessed as reduction in Ca+2 influx by FLIPR assyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistamine H1 receptor(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50534287(CHEMBL4519018)
Affinity DataIC50: 201nMAssay Description:Antagonist activity at H1 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50308247(CHEMBL1215855 | ibogaine)
Affinity DataIC50: 220nMAssay Description:Antagonist activity at recombinant alpha3beta4 nAChR in HEK293 cells by voltage-clamp based electrophysiological methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50618169(CHEMBL5428298)
Affinity DataIC50: 242nMAssay Description:Antagonist activity at nAChR alpha7 in human SH-SY5Y cells assessed as increase in intracellular calcium level preincubated for 10 mins followed by c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50534293(CHEMBL3341966)
Affinity DataIC50: 260nMAssay Description:Partial agonist activity at alpha3beta4 nAChR in HEK293 cells assessed as reduction in Ca+2 influx by FLIPR assyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50534287(CHEMBL4519018)
Affinity DataIC50: 300nMAssay Description:Antagonist activity at alpha4beta2 nAChR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M5(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50534287(CHEMBL4519018)
Affinity DataIC50: 325nMAssay Description:Antagonist activity at muscarinic M5 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50618167(CHEMBL5398383)
Affinity DataIC50: 410nMAssay Description:Antagonist activity at nAChR alpha3beta4 in human SH-SY5Y cells assessed as increase in intracellular calcium level preincubated for 10 mins followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma intracellular receptor 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50534287(CHEMBL4519018)
Affinity DataIC50: 418nMAssay Description:Antagonist activity at sigma 2 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50618169(CHEMBL5428298)
Affinity DataIC50: 440nMAssay Description:Antagonist activity at nAChR alpha3beta4 in human SH-SY5Y cells assessed as increase in intracellular calcium level preincubated for 10 mins followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50618168(CHEMBL5428848)
Affinity DataIC50: 630nMAssay Description:Antagonist activity at nAChR alpha3beta4 in human SH-SY5Y cells assessed as increase in intracellular calcium level preincubated for 10 mins followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50534287(CHEMBL4519018)
Affinity DataIC50: 661nMAssay Description:Antagonist activity at muscarinic M4 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50618164(CHEMBL5440131)
Affinity DataIC50: 750nMAssay Description:Antagonist activity at recombinant alpha3beta4 nAChR in HEK293 cells by voltage-clamp based electrophysiological methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50618165(CHEMBL5434420)
Affinity DataIC50: 770nMAssay Description:Inhibition of alpha3beta4 (unknown origin) by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50308247(CHEMBL1215855 | ibogaine)
Affinity DataIC50: 950nMAssay Description:Antagonist activity at human alpha3beta4 nAChRs expressed in HEK293 cells assessed as inhibition of (+/-)-epibatidine-induced Ca+2 influx incubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50308247(CHEMBL1215855 | ibogaine)
Affinity DataIC50: 1.00E+3nMAssay Description:Antagonist activity at alpha4beta2 nAChR in HEK293 cells by voltage-clamp based electrophysiological methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50045046(CHEMBL3341962)
Affinity DataIC50: 1.10E+3nMAssay Description:Antagonist activity at rat alpha3beta4 nAChRs expressed in HEK293 cells assessed as inhibition of (+/-)-epibatidine-induced Ca+2 influx measured for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50618164(CHEMBL5440131)
Affinity DataIC50: 1.47E+3nMAssay Description:Antagonist activity at human alpha3beta4 nAChRs expressed in HEK293 cells assessed as inhibition of (+/-)-epibatidine-induced Ca+2 influx incubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50618168(CHEMBL5428848)
Affinity DataIC50: 2.57E+3nMAssay Description:Antagonist activity at nAChR alpha7 in human SH-SY5Y cells assessed as increase in intracellular calcium level preincubated for 10 mins followed by c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50308247(CHEMBL1215855 | ibogaine)
Affinity DataIC50: 4.09E+3nMAssay Description:Inhibition of human ERG by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50618164(CHEMBL5440131)
Affinity DataIC50: 6.30E+3nMAssay Description:Inhibition of nAChR alpha4beta2 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50618164(CHEMBL5440131)
Affinity DataIC50: 2.00E+4nMAssay Description:Antagonist activity at alpha4beta2 nAChR in HEK293 cells by voltage-clamp based electrophysiological methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50618164(CHEMBL5440131)
Affinity DataIC50: 3.47E+4nMAssay Description:Inhibition of nAChR alpha7 receptor (unknown origin) assessed as inhibition of calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50618167(CHEMBL5398383)
Affinity DataIC50: 1.00E+5nMAssay Description:Antagonist activity at nAChR alpha7 in human SH-SY5Y cells assessed as increase in intracellular calcium level preincubated for 10 mins followed by c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50618165(CHEMBL5434420)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of nAChR alpha4beta2 (unknown origin) by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50618165(CHEMBL5434420)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of nAChR alpha7 (unknown origin) by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50618165(CHEMBL5434420)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of nAChR alpha3beta2 (unknown origin) by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50618166(CHEMBL5401803)
Affinity DataIC50: 1.00E+5nMAssay Description:Antagonist activity at rat alpha4beta2 nACh receptor expressed in Xenopus oocyte by voltage-clamp based electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma intracellular receptor 2(Bos taurus)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50308247(CHEMBL1215855 | ibogaine)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]-DTG from calf hippocampus sigma 2 receptor assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMu-type opioid receptor(Bovine)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50618164(CHEMBL5440131)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]-DAGO from calf cortex MOR receptor assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50308247(CHEMBL1215855 | ibogaine)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]Ibogaine from human alpha3beta4 nAChRs expressed in HEK293 cells assessed as inhibition constant incubated for 2 hrs by scintilla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMu-type opioid receptor(Bovine)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50308247(CHEMBL1215855 | ibogaine)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]-DAGO from calf cortex MOR receptor assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetKappa-type opioid receptor(Bovine)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50308247(CHEMBL1215855 | ibogaine)
Affinity DataKi:  2.20nMAssay Description:Displacement of [3H]-U69593 from calf cortex KOR receptor assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50534287(CHEMBL4519018)
Affinity DataKi:  2.60nMAssay Description:Binding affinity to rat alpha3beta4 nAChR expressed in HEK cells assessed as inhibition constant measured after 2 hrs in the presence of [3H]epibatid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetKappa-type opioid receptor(Bovine)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50618164(CHEMBL5440131)
Affinity DataKi:  5.10nMAssay Description:Displacement of [3H]-U69593 from calf cortex KOR receptor assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma intracellular receptor 2(Bos taurus)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50618164(CHEMBL5440131)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]-DTG from calf hippocampus sigma 2 receptor assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMuscarinic receptor M1(Bovine)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50308247(CHEMBL1215855 | ibogaine)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]-pirenzepine from calf cortex Muscarinic M1 receptor assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50534293(CHEMBL3341966)
Affinity DataKi:  21nMAssay Description:Displacement of [3H] epibatidine from alpha3beta4 nAChR in HEK293 cells assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50534293(CHEMBL3341966)
Affinity DataKi:  21nMAssay Description:Displacement of [3H] epibatidine from alpha4beta2 nAChR in HEK293 cells assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMuscarinic receptor M1(Bovine)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50618164(CHEMBL5440131)
Affinity DataKi:  32nMAssay Description:Displacement of [3H]-pirenzepine from calf cortex Muscarinic M1 receptor assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50534287(CHEMBL4519018)
Affinity DataKi:  222nMAssay Description:Binding affinity to rat alpha7 nAChR expressed in HEK cells assessed as inhibition constant measured after 2 hrs in the presence of [3H]epibatidineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50618164(CHEMBL5440131)
Affinity DataKi:  400nMAssay Description:Displacement of [3H]imipramine from human alpha3beta4 nAChRs expressed in HEK293 cells assessed as inhibition constant incubated for 2 hrs by scintil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50534287(CHEMBL4519018)
Affinity DataKi:  477nMAssay Description:Binding affinity to rat alpha4beta2 nAChR expressed in HEK cells assessed as inhibition constant measured after 2 hrs in the presence of [3H]epibatid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
Displayed 1 to 50 (of 53 total ) | Next | Last >>
Jump to: