Compile Data Set for Download or QSAR
Report error Found 191 Enz. Inhib. hit(s) with all data for entry = 50015936
Target5-hydroxytryptamine receptor 1A(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM86708(CHEMBL31354 | CHEMBL514874 | NSC_104911 | CAS_1467...)
Affinity DataKd:  0.200nMAssay Description:Binding affinity to 5-HT1A receptor (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50035513(CHEMBL286607 | CHEMBL1775000 | 4-Fluoro-N-{2-[4-(2...)
Affinity DataKd:  0.340nMAssay Description:Binding affinity to 5-HT1A receptor (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetD(4) dopamine receptor(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM86708(CHEMBL31354 | CHEMBL514874 | NSC_104911 | CAS_1467...)
Affinity DataKd:  2.40nMAssay Description:Binding affinity to D4 receptor (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1B(Guinea pig)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50590649(CHEMBL5209320)
Affinity DataKd:  0.400nMAssay Description:Binding affinity to guinea pig 5-HT1B receptor assessed as dissociation constant by autoradiographic analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetSerotonin 2 (5-HT2) receptor(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50590657(Eplivanserin | SR-46349 | SR46349 | EPLIVANSERIN)
Affinity DataKd:  1.20nMAssay Description:Binding affinity to 5-HT2 receptor (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50095027((2,3-Dimethoxy-phenyl)-{1-[2-(4-fluoro-phenyl)-eth...)
Affinity DataKd:  0.140nMAssay Description:Binding affinity to human brain homogenate 5-HT2A assessed as dissociation constant by quantitative autoradiographic analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50590663(CHEMBL5175726)
Affinity DataKd:  0.110nMAssay Description:Binding affinity to rat frontal cortex 5-HT2A assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50590664(CHEMBL5199680)
Affinity DataEC50:  21nMAssay Description:Agonist activity at 5-HT1A receptor (unknown origin) transfected in HEK293 cells by calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50122872(4-Amino-5-chloro-2,3-dihydro-benzofuran-7-carboxyl...)
Affinity DataKd:  2nMAssay Description:Binding affinity to 5-HT4 receptor (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetD(2) dopamine receptor(Rat)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50004813(8-[4-(4-Fluoro-phenyl)-4-oxo-butyl]-3-methyl-1-phe...)
Affinity DataIC50: 0.230nMAssay Description:Displacement of [3H]-spiperone from rat striatum D2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50590646(CHEMBL5182997)
Affinity DataIC50: 0.580nMAssay Description:Displacement of [3H]-8-OH-DPAT from rat hippocampal membrane 5HT1A receptor by CEREP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50590647(CHEMBL5189175)
Affinity DataIC50: 0.860nMAssay Description:Displacement of [3H]-8-OH-DPAT from rat hippocampal membrane 5HT1A receptor by CEREP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50590644(CHEMBL5181731)
Affinity DataIC50: 1nMAssay Description:Displacement of [3H]-8-OH-DPAT from rat hippocampal membrane 5HT1A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50590645(CHEMBL5181399)
Affinity DataIC50: 1.20nMAssay Description:Displacement of [3H]-8-OH-DPAT from rat hippocampal membrane 5HT1A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50035320(8-Dipropylamino-6,7,8,9-tetrahydro-3H-benzo[e]indo...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of 5-HT1A receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetSerotonin 2 (5-HT2) receptor(Rat)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50004813(8-[4-(4-Fluoro-phenyl)-4-oxo-butyl]-3-methyl-1-phe...)
Affinity DataIC50: 1.30nMAssay Description:Displacement of [3H]-spiperone from rat frontal cortex 5-HT2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetSerotonin 2 (5-HT2) receptor(Rat)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50001800(CHEMBL343444 | 1-(2-{4-[3-(4-Fluoro-phenyl)-2,5-di...)
Affinity DataIC50: 3.40nMAssay Description:Displacement of [3H]-Ketanserin from rat cortical membrane 5-HT2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM86708(CHEMBL31354 | CHEMBL514874 | NSC_104911 | CAS_1467...)
Affinity DataIC50: 4.20nMAssay Description:Displacement of [3H]-8-OH-DPAT from Sprague-Dawley rat hippocampal membrane 5HT1A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50056034(Cyclohexanecarboxylic acid {2-[4-(2-methoxy-phenyl...)
Affinity DataIC50: 4.30nMAssay Description:Displacement of [3H]-8-OH-DPAT from rat hippocampal membrane 5HT1A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetAlpha-1A adrenergic receptor(Rat)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50004813(8-[4-(4-Fluoro-phenyl)-4-oxo-butyl]-3-methyl-1-phe...)
Affinity DataIC50: 10nMAssay Description:Displacement of [3H]prazosin from rat cerebral cortex alpha1 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50033857(1-[3-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...)
Affinity DataIC50: 43nMAssay Description:Inhibition of alpha 1A adrenergic receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1B(Guinea pig)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50590649(CHEMBL5209320)
Affinity DataKi:  0.0100nMAssay Description:Binding affinity to guinea pig 5-HT1B receptor assessed as inhibition constant by autoradiographic analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50590640(CHEMBL5177580)
Affinity DataKi:  0.0400nMAssay Description:Binding affinity to 5-HT1A receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50472582(CHEMBL45422)
Affinity DataKi:  0.0400nMAssay Description:Binding affinity to 5-HT1A receptor (unknown origin) assessed as inhibition constant by scintillation spectroscopic analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50590648(CHEMBL5202019)
Affinity DataKi:  0.0990nMAssay Description:Binding affinity to rat brain homogenate 5-HT1A receptor assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50438565(CHEMBL2413153)
Affinity DataKi:  0.100nMAssay Description:Binding affinity to 5-HT1A receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50039824(N-{2-[4-(2,3-Dihydro-benzo[1,4]dioxin-5-yl)-pipera...)
Affinity DataKi:  0.100nMAssay Description:Binding affinity to human 5-HT1A receptor expressed in CHO cells assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50113332(CHEMBL62919 | altanserin | 3-(2-(4-(4-fluorobenzoy...)
Affinity DataKi:  0.130nMAssay Description:Displacement of [3H]-Ketanserin from rat frontal cortex 5-HT2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50182020(2-(4-(4-(3-methoxyphenyl)piperazin-1-yl)butyl)-4-m...)
Affinity DataKi:  0.150nMAssay Description:Binding affinity to 5-HT1A receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50011175(CHEMBL3260313)
Affinity DataKi:  0.160nMAssay Description:Binding affinity to human recombinant 5-HT2A assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50590673(CHEMBL5179460)
Affinity DataKi:  0.170nMAssay Description:Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50590637(CHEMBL5189925)
Affinity DataKi:  0.190nMAssay Description:Binding affinity to 5-HT1A receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50590663(CHEMBL5175726)
Affinity DataKi:  0.200nMAssay Description:Binding affinity to rat frontal cortex 5-HT2A assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM85862(1-(2-Chloro-3,4-dimethoxybenzyl)-6-methyl-2,3,4,9-...)
Affinity DataKi:  0.200nMAssay Description:Binding affinity to human 5-HT2B assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50590671(CHEMBL5196234)
Affinity DataKi:  0.220nMAssay Description:Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetSerotonin 2 (5-HT2) receptor(Rat)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50010044(FANANSERIN | ChEMBL_131689 | 2-{3-[4-(4-Fluoro-phe...)
Affinity DataKi:  0.260nMAssay Description:Binding affinity to rat cerebral cortex homogenate 5-HT2 receptor assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50448450(CHEMBL3126112)
Affinity DataKi:  0.300nMAssay Description:Binding affinity to 5-HT4 receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50249134(RS-127445 | CHEMBL473186 | 4-(4-fluoronaphthalen-1...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity to 5-HT2B (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50590681(CHEMBL5193649)
Affinity DataKi:  0.300nMAssay Description:Binding affinity to human 5-HT2B assessed as inhibition constant in microplate beta scintillation counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50590629(CHEMBL5205609)
Affinity DataKi:  0.310nMAssay Description:Binding affinity to 5-HT1A receptor in human HeLa cell membrane assessed as inhibition constant by Packard top-counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50590672(CHEMBL5184712)
Affinity DataKi:  0.320nMAssay Description:Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50590630(CHEMBL5181992)
Affinity DataKi:  0.450nMAssay Description:Displacement of [3H]-8-OH-DPAT from Sprague-Dawley rat hippocampal membrane 5HT1A receptor incubated for 10 mins by liquid scintillation analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50001775(cid_5074 | Ritanserine | 6-(2-{4-[Bis-(4-fluoro-ph...)
Affinity DataKi:  0.450nMAssay Description:Binding affinity to 5-HT2A (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50033857(1-[3-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity to 5-HT1A receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50056944(4-Fluoro-N-{2-[4-(1,2,3,4-tetrahydro-naphthalen-1-...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity to 5-HT1A receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50590643(CHEMBL5201742)
Affinity DataKi:  0.5nMAssay Description:Binding affinity to 5-HT1A receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50004813(8-[4-(4-Fluoro-phenyl)-4-oxo-butyl]-3-methyl-1-phe...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity to rat frontal cortex homogenate 5-HT2A by ketanserin assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetSerotonin 2 (5-HT2) receptor(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50590650(CHEMBL5204619)
Affinity DataKi:  0.5nMAssay Description:Binding affinity to cerebrum 5-HT2 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM139370(ACP-103 | Pimavanserin | Pimavanserin hydrochlorid...)
Affinity DataKi:  0.5nMAssay Description:Inverse agonist activity at 5-HT2A receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50590660(CHEMBL5203398)
Affinity DataKi:  0.5nMAssay Description:Binding affinity to human 5-HT2A assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
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