Compile Data Set for Download or QSAR
Report error Found 24 Enz. Inhib. hit(s) with all data for entry = 50001487
TargetAmine oxidase [flavin-containing] B(Human)
Iqog, Csic

Curated by ChEMBL
LigandPNGBDBM50281388(CHEMBL4173258)
Affinity DataIC50: 78nMAssay Description:Inhibition of recombinant human MAO-B using tyramine as substrate ampliflu red dye based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2020
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Iqog, Csic

Curated by ChEMBL
LigandPNGBDBM50281388(CHEMBL4173258)
Affinity DataIC50: 145nMAssay Description:Inhibition of recombinant human MAO-A using tyramine as substrate ampliflu red dye based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2020
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Iqog, Csic

Curated by ChEMBL
LigandPNGBDBM50281388(CHEMBL4173258)
Affinity DataIC50: 530nMAssay Description:Inhibition of recombinant human AChE using acetylthiocholine iodide as substrate by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2020
Entry Details Article
PubMed
TargetCholinesterase(Human)
Iqog, Csic

Curated by ChEMBL
LigandPNGBDBM50281388(CHEMBL4173258)
Affinity DataIC50: 1.69E+3nMAssay Description:Inhibition of human plasma BuChE using acetylthiocholine iodide as substrate by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2020
Entry Details Article
PubMed
TargetVesicular acetylcholine transporter(Rat)
Iqog, Csic

Curated by ChEMBL
LigandPNGBDBM50359391(CHEMBL1929421)
Affinity DataKi:  2.60nMAssay Description:Displacement of (-)-[3H]vesamicol from rat VAChT expressed in rat PC12 cell membranes after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2020
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Iqog, Csic

Curated by ChEMBL
LigandPNGBDBM50359391(CHEMBL1929421)
Affinity DataKi:  2.80nMAssay Description:Displacement of (+)-[3H]pentazocine from human sigma1 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting meth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2020
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Iqog, Csic

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  5.40nMAssay Description:Displacement of (+)-[3H]pentazocine from sigma1 receptor in rat brain membranes after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSigma non-opioid intracellular receptor 1(Human)
Iqog, Csic

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  5.90nMAssay Description:Displacement of (+)-[3H]pentazocine from human sigma1 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting meth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistamine H3 receptor(Human)
Iqog, Csic

Curated by ChEMBL
LigandPNGBDBM50281388(CHEMBL4173258)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human H3R expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2020
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Iqog, Csic

Curated by ChEMBL
LigandPNGBDBM50338990(CHEMBL2311153 | N-phenylpropyl-N''-3,4-dimethoxyph...)
Affinity DataKi:  14nMAssay Description:Displacement of (+)-[3H]pentazocine from sigma1 receptor in rat brain membranes after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2020
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Iqog, Csic

Curated by ChEMBL
LigandPNGBDBM50018078(CHEMBL20943 | V-100 | 2-(4-Phenyl-piperidin-1-yl)-...)
Affinity DataKi:  27nMAssay Description:Displacement of (+)-[3H]pentazocine from sigma1 receptor in rat brain membranes after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2020
Entry Details Article
PubMed
TargetSigma intracellular receptor 2(Rat)
Iqog, Csic

Curated by ChEMBL
LigandPNGBDBM50062551(Dolutegravir | GSK1349572 | CHEBI:76010 | S-349572)
Affinity DataKi:  32nMAssay Description:Displacement of [3H]DTG from sigma2 receptor in rat liver membranes after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2020
Entry Details Article
PubMed
TargetSigma intracellular receptor 2(Rat)
Iqog, Csic

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  44nMAssay Description:Displacement of [3H]DTG from sigma2 receptor in rat liver membranes after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2020
Entry Details Article
PubMed
TargetVesicular acetylcholine transporter(Rat)
Iqog, Csic

Curated by ChEMBL
LigandPNGBDBM50281388(CHEMBL4173258)
Affinity DataKi:  46nMAssay Description:Displacement of (-)-[3H]vesamicol from rat VAChT expressed in rat PC12 cell membranes after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2020
Entry Details Article
PubMed
TargetVesicular acetylcholine transporter(Rat)
Iqog, Csic

Curated by ChEMBL
LigandPNGBDBM50018078(CHEMBL20943 | V-100 | 2-(4-Phenyl-piperidin-1-yl)-...)
Affinity DataKi:  49nMAssay Description:Displacement of (-)-[3H]vesamicol from rat VAChT expressed in rat PC12 cell membranes after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2020
Entry Details Article
PubMed
TargetSigma intracellular receptor 2(Rat)
Iqog, Csic

Curated by ChEMBL
LigandPNGBDBM50359391(CHEMBL1929421)
Affinity DataKi:  50nMAssay Description:Displacement of [3H]DTG from sigma2 receptor in rat liver membranes after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2020
Entry Details Article
PubMed
TargetSigma intracellular receptor 2(Rat)
Iqog, Csic

Curated by ChEMBL
LigandPNGBDBM50338990(CHEMBL2311153 | N-phenylpropyl-N''-3,4-dimethoxyph...)
Affinity DataKi:  62nMAssay Description:Displacement of [3H]DTG from sigma2 receptor in rat liver membranes after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2020
Entry Details Article
PubMed
TargetSigma intracellular receptor 2(Rat)
Iqog, Csic

Curated by ChEMBL
LigandPNGBDBM50018078(CHEMBL20943 | V-100 | 2-(4-Phenyl-piperidin-1-yl)-...)
Affinity DataKi:  63nMAssay Description:Displacement of [3H]DTG from sigma2 receptor in rat liver membranes after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2020
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Iqog, Csic

Curated by ChEMBL
LigandPNGBDBM50281388(CHEMBL4173258)
Affinity DataKi:  65nMAssay Description:Displacement of (+)-[3H]pentazocine from human sigma1 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting meth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2020
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Iqog, Csic

Curated by ChEMBL
LigandPNGBDBM50062551(Dolutegravir | GSK1349572 | CHEBI:76010 | S-349572)
Affinity DataKi:  217nMAssay Description:Displacement of (+)-[3H]pentazocine from sigma1 receptor in rat brain membranes after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2020
Entry Details Article
PubMed
TargetSigma intracellular receptor 2(Rat)
Iqog, Csic

Curated by ChEMBL
LigandPNGBDBM50281388(CHEMBL4173258)
Affinity DataKi:  326nMAssay Description:Displacement of [3H]DTG from sigma2 receptor in rat liver membranes after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2020
Entry Details Article
PubMed
TargetVesicular acetylcholine transporter(Rat)
Iqog, Csic

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  391nMAssay Description:Displacement of (-)-[3H]vesamicol from rat VAChT expressed in rat PC12 cell membranes after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2020
Entry Details Article
PubMed
TargetVesicular acetylcholine transporter(Rat)
Iqog, Csic

Curated by ChEMBL
LigandPNGBDBM50338990(CHEMBL2311153 | N-phenylpropyl-N''-3,4-dimethoxyph...)
Affinity DataKi:  492nMAssay Description:Displacement of (-)-[3H]vesamicol from rat VAChT expressed in rat PC12 cell membranes after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2020
Entry Details Article
PubMed
TargetVesicular acetylcholine transporter(Rat)
Iqog, Csic

Curated by ChEMBL
LigandPNGBDBM50062551(Dolutegravir | GSK1349572 | CHEBI:76010 | S-349572)
Affinity DataKi:  4.52E+3nMAssay Description:Displacement of (-)-[3H]vesamicol from rat VAChT expressed in rat PC12 cell membranes after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2020
Entry Details Article
PubMed