Compile Data Set for Download or QSAR
Report error Found 13 Enz. Inhib. hit(s) with all data for entry = 50002419
TargetHistone deacetylase 8(Human)
Mazandaran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50397360(CHEMBL2170177 | US10188756, Compound CN110)
Affinity DataIC50: 10nMAssay Description:Inhibition of HDAC8 (unknown origin) preincubated for 15 mins followed by acetyl-Gly-Ala-(N-acetyl-Lys)-amino-4-methylcoumarin substrate addition and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetHistone deacetylase (HDAC1 and HDAC2)(Human)
Mazandaran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50220811(CHEMBL56157)
Affinity DataIC50: 15nMAssay Description:Inhibition of HDAC1/2 in human K562 nuclear extract using (QSY-7)-RGGRGLGK(Ac)-GGARRHRK(TAMRA)NH2 as substrate incubated for 30 mins by fluorescence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Mazandaran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM19428(NVP-LAQ824 | (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl...)
Affinity DataIC50: 32nMAssay Description:Inhibition of human H1299 cells derived HDAC using biotin-labeled SGRGKGGKGLGKGGAKRHRKVLRD peracetylated with [3H]acetate at lysine residue as substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Mazandaran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50458326(CHEMBL4209288)
Affinity DataIC50: 58nMAssay Description:Inhibition of PIM1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Mazandaran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50134232((E)-N-Hydroxy-3-(4-{[2-(1H-indol-3-yl)-ethylamino]...)
Affinity DataIC50: 63nMAssay Description:Inhibition of human H1299 cells derived HDAC using biotin-labeled SGRGKGGKGLGKGGAKRHRKVLRD peracetylated with [3H]acetate at lysine residue as substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Mazandaran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50458322(CHEMBL4206921)
Affinity DataIC50: 67nMAssay Description:Inhibition of PIM1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Mazandaran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50458324(CHEMBL4202863)
Affinity DataIC50: 74nMAssay Description:Inhibition of HDAC in human HeLa nuclear extract preincubated for 10 mins followed by Boc-Lys(acetyl)-AMC substrate addition measured after 30 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Mazandaran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50458323(CHEMBL4207448)
Affinity DataIC50: 78nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Mazandaran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50458325(CHEMBL342474)
Affinity DataIC50: 150nMAssay Description:Inhibition of human H1299 cells derived HDAC using biotin-labeled SGRGKGGKGLGKGGAKRHRKVLRD peracetylated with [3H]acetate at lysine residue as substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetHistone deacetylase 4(Human)
Mazandaran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50458324(CHEMBL4202863)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of HDAC4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSigma intracellular receptor 2(Rat)
Mazandaran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM82353(1-{3-[4-(substitutedphenyl)piperazin1-yl]propyl}-1...)
Affinity DataKi:  9.90nMAssay Description:Displacement of [3H]-di-o-tolylguanidine from sigma-2 receptor in rat liver membranes after 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Mazandaran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM82351(1-{[4-(substitutedphenyl/phenylethyl)piperazin1-yl...)
Affinity DataKi:  14nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma-1 receptor in guinea pig brain membranes after 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSigma intracellular receptor 2(Rat)
Mazandaran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM82351(1-{[4-(substitutedphenyl/phenylethyl)piperazin1-yl...)
Affinity DataKi:  56nMAssay Description:Displacement of [3H]-di-o-tolylguanidine from sigma-2 receptor in rat liver membranes after 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed