Compile Data Set for Download or QSAR
Report error Found 105 Enz. Inhib. hit(s) with all data for entry = 50019134
TargetGlutathione hydrolase 1 proenzyme(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50615643(CHEMBL5286162)
Affinity DataIC50: 39nMAssay Description:Inhibition of human GGT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetGlutathione hydrolase 1 proenzyme(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50615644(Crobenetine | CROBENETINE)
Affinity DataIC50: 322nMAssay Description:Inhibition of human GGT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetKappa-type opioid receptor(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50615626(CHEMBL5274252)
Affinity DataKi:  0.410nMAssay Description:Displacement of [3H]-U69593 from KOR receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50615620(CHEMBL3040082)
Affinity DataKi:  0.670nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane assessed as inhibition constant measured after 120 mins by sci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50615619(CHEMBL5282359)
Affinity DataKi:  0.960nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane assessed as inhibition constant measured for 150 mins in prese...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50615621(CHEMBL5268414)
Affinity DataKi:  0.970nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane assessed as inhibition constant measured after 120 mins by sci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50615622(CHEMBL5282332)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane assessed as inhibition constant measured after 120 mins by sci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50615628(CHEMBL5275525)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane assessed as inhibition constant measured for 150 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50615630(CHEMBL5275160)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane assessed as inhibition constant measured for 150 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50615636(CHEMBL5279648)
Affinity DataKi:  1.70nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50615629(CHEMBL5290521)
Affinity DataKi:  1.80nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane assessed as inhibition constant measured for 150 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50615635(CHEMBL5285753)
Affinity DataKi:  1.80nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50615633(CHEMBL5289055)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50615632(CHEMBL5280576)
Affinity DataKi:  2.60nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50615616(CHEMBL5289078)
Affinity DataKi:  3.10nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane assessed as inhibition constant measured after 120 mins by sci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50615618(CHEMBL5278788)
Affinity DataKi:  3.40nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane assessed as inhibition constant measured for 150 mins in prese...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50059777((2R,6S)-3-((R)-2-Methoxy-propyl)-6,11,11-trimethyl...)
Affinity DataKi:  4.5nMAssay Description:Antagonist activity at NMDA receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50064196((2S,6R,11S)-6,11-Dimethyl-3-[2-(methyl-phenyl-amin...)
Affinity DataKi:  5.60nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane assessed as inhibition constant measured for 150 mins in prese...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50064195((2S,6R,11S)-6,11-Dimethyl-3-(2-phenylamino-ethyl)-...)
Affinity DataKi:  5.90nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane assessed as inhibition constant measured for 150 mins in prese...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50615616(CHEMBL5289078)
Affinity DataKi:  6.10nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane assessed as inhibition constant measured for 150 mins in prese...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50064191((2S,6R,11S)-6,11-Dimethyl-3-(2-pyrrolidin-1-yl-eth...)
Affinity DataKi:  7.40nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane assessed as inhibition constant measured for 150 mins in prese...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50064193((2S,6R,11S)-6,11-Dimethyl-3-(2-piperidin-1-yl-ethy...)
Affinity DataKi:  9.60nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane assessed as inhibition constant measured for 150 mins in prese...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50064188((2S,6R,11S)-6,11-Dimethyl-3-(2-morpholin-4-yl-ethy...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane assessed as inhibition constant measured for 150 mins in prese...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetSigma intracellular receptor 2(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50615641(CHEMBL5276627)
Affinity DataKi:  16nMAssay Description:Inhibition of sigma 2 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetSigma intracellular receptor 2(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50370780(CHEMBL4164801)
Affinity DataKi:  16nMAssay Description:Inhibition of sigma 2 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50615631(CHEMBL5284154)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane assessed as inhibition constant measured for 150 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50064187((2S,6R,11S)-3-(2-Azepan-1-yl-ethyl)-6,11-dimethyl-...)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane assessed as inhibition constant measured for 150 mins in prese...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50615612(CHEMBL5275685)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50615615(CHEMBL5289807)
Affinity DataKi:  21nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetSigma intracellular receptor 2(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50615642(CHEMBL5270179)
Affinity DataKi:  23nMAssay Description:Inhibition of sigma 2 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetSigma intracellular receptor 2(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50615640(CHEMBL5281610)
Affinity DataKi:  27nMAssay Description:Inhibition of sigma 2 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetMu-type opioid receptor(Rat)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50064196((2S,6R,11S)-6,11-Dimethyl-3-[2-(methyl-phenyl-amin...)
Affinity DataKi:  29nMAssay Description:Displacement of [ 3H]-naloxone from rat brain membrane mu opioid receptor assessed as inhibition constant by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50615617(CHEMBL5291126)
Affinity DataKi:  32nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane assessed as inhibition constant measured for 150 mins in prese...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50615613(CHEMBL5280329)
Affinity DataKi:  34nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetSigma intracellular receptor 2(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50615639(CHEMBL5270567)
Affinity DataKi:  34nMAssay Description:Inhibition of sigma 2 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50615616(CHEMBL5289078)
Affinity DataKi:  35nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane assessed as inhibition constant measured for 150 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetSigma intracellular receptor 2(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50615613(CHEMBL5280329)
Affinity DataKi:  42nMAssay Description:Displacement of [3H]DTG from sigma 2 receptor (unknown origin) assessed as inhibition constant in presence of (+)-SKF10047 by radioligand binding ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50001044((1S,9S,13S)-10-allyl-1,13-dimethyl-10-azatricyclo[...)
Affinity DataKi:  60nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane assessed as inhibition constant measured after 120 mins by sci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50615623(CHEMBL5280610)
Affinity DataKi:  67nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetSigma intracellular receptor 2(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50370759(CHEMBL4176080)
Affinity DataKi:  71nMAssay Description:Inhibition of sigma 2 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50615625(CHEMBL5276035)
Affinity DataKi:  75nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetMu-type opioid receptor(Rat)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50064195((2S,6R,11S)-6,11-Dimethyl-3-(2-phenylamino-ethyl)-...)
Affinity DataKi:  80nMAssay Description:Displacement of [ 3H]-naloxone from rat brain membrane mu opioid receptor assessed as inhibition constant by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50615638(CHEMBL5316208)
Affinity DataKi:  80nMAssay Description:Inhibition of sigma 1 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetSigma intracellular receptor 2(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50615616(CHEMBL5289078)
Affinity DataKi:  83nMAssay Description:Displacement of [3H]DTG from sigma 2 receptor (unknown origin) assessed as inhibition constant in presence of haloperidol measured for 120 mins by sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50615614(CHEMBL5267553)
Affinity DataKi:  91nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetSigma intracellular receptor 2(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50064195((2S,6R,11S)-6,11-Dimethyl-3-(2-phenylamino-ethyl)-...)
Affinity DataKi:  111nMAssay Description:Displacement of [3H]DTG from sigma 2 receptor (unknown origin) assessed as inhibition constant incubated for 120 mins in presence of (+)-SKF10047 by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetSigma intracellular receptor 2(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50064193((2S,6R,11S)-6,11-Dimethyl-3-(2-piperidin-1-yl-ethy...)
Affinity DataKi:  114nMAssay Description:Displacement of [3H]DTG from sigma 2 receptor (unknown origin) assessed as inhibition constant incubated for 120 mins in presence of (+)-SKF10047 by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetSigma intracellular receptor 2(Rat)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50615618(CHEMBL5278788)
Affinity DataKi:  115nMAssay Description:Displacement of [3H]DTG from sigma 2 receptor in rat liver membranes assessed as inhibition constant presence of haloperidol by scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetSigma intracellular receptor 2(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50064196((2S,6R,11S)-6,11-Dimethyl-3-[2-(methyl-phenyl-amin...)
Affinity DataKi:  124nMAssay Description:Displacement of [3H]DTG from sigma 2 receptor (unknown origin) assessed as inhibition constant incubated for 120 mins in presence of (+)-SKF10047 by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetSigma intracellular receptor 2(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50615612(CHEMBL5275685)
Affinity DataKi:  130nMAssay Description:Displacement of [3H]DTG from sigma 2 receptor (unknown origin) assessed as inhibition constant in presence of (+)-SKF10047 by radioligand binding ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
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