Compile Data Set for Download or QSAR
Report error Found 74 Enz. Inhib. hit(s) with all data for entry = 50012661
TargetSodium-dependent serotonin transporter(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50028094((1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-te...)
Affinity DataIC50: 0.190nMAssay Description:Inhibition of SERT (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM15581(US8633208, Clorgyline | [3-(2,4-dichlorophenoxy)pr...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of MAO-A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium-dependent serotonin transporter(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM30130(Prozac | cid_62857 | Fluoxetin | CHEMBL41 | CHEMBL...)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of SERT (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50028091((1E)-5-methoxy-1-[4-(trifluoromethyl)phenyl]pentan...)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of SERT (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAcetylcholinesterase(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM8960(2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...)
Affinity DataIC50: 9nMAssay Description:Inhibition of acetylcholinesterase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50338990(CHEMBL2311153 | N-phenylpropyl-N''-3,4-dimethoxyph...)
Affinity DataIC50: 17nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membranes by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50010859(CHEMBL11 | Imipramin | IMIPRAMINE HYDROCHLORIDE | ...)
Affinity DataIC50: 29nMAssay Description:Inhibition of SERT (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSigma non-opioid intracellular receptor 1(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50559171(Blarcamesine | Anavex 2-73 | Anavex)
Affinity DataIC50: 860nMAssay Description:Binding affinity to sigma-1 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50559171(Blarcamesine | Anavex 2-73 | Anavex)
Affinity DataIC50: 3.30E+3nMAssay Description:Binding affinity to muscarinic acetylcholine receptor M4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50559171(Blarcamesine | Anavex 2-73 | Anavex)
Affinity DataIC50: 3.30E+3nMAssay Description:Binding affinity to muscarinic acetylcholine receptor M3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50559171(Blarcamesine | Anavex 2-73 | Anavex)
Affinity DataIC50: 3.30E+3nMAssay Description:Binding affinity to muscarinic acetylcholine receptor M2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50559171(Blarcamesine | Anavex 2-73 | Anavex)
Affinity DataIC50: 3.30E+3nMAssay Description:Binding affinity to muscarinic acetylcholine receptor M1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  0.120nMAssay Description:Antagonist activity at dopamine D2 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50559185(CHEMBL4743313)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain homogenate incubated for 150 mins by liquid scintillation counting meth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50559179(CHEMBL4792161)
Affinity DataKi:  0.280nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in Dunkin-Hartley guinea pig brain membranes incubated for 180 mins by liquid scintillatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50064172(CHEMBL39900 | 1-benzylspiro[hexahydropyridine-4,2'...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in rat liver membranes incubated for 60 mins in presence of [3H]DTG by radioactivity metho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50559180(CHEMBL4749734)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in Dunkin guinea pig brain membranes incubated for 120 mins by scintillation counting meth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50559173(CHEMBL4796613)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain cortex membranes incubated for 120 mins by solid scintillation counting...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50559183(CHEMBL4796879)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in rat liver membranes incubated for 60 mins in presence of [3H]DTG by radioactivity metho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50559184(CHEMBL4763051)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in rat liver membranes incubated for 60 mins in presence of [3H]DTG by radioactivity metho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50559182(CHEMBL4744344)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in rat liver membranes incubated for 60 mins in presence of [3H]DTG by radioactivity metho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM25870(CITALOPRAM HYDROBROMIDE | [3H]Escitalopram | Escit...)
Affinity DataKi:  1.60nMAssay Description:Inhibition of SERT (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50559174(CHEMBL4782131)
Affinity DataKi:  1.90nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain cortex membranes incubated for 120 mins by solid scintillation counting...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50001028(Talwin | PENTAZOCINE (+) | Pentazocine,(+/-) | 6,1...)
Affinity DataKi:  2.20nMAssay Description:Binding affinity to kappa opioid receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50559177(CHEMBL4760592)
Affinity DataKi:  2.40nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain cortex membranes incubated for 120 mins by solid scintillation counting...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Mouse)
Soochow University

Curated by ChEMBL
LigandPNGBDBM15581(US8633208, Clorgyline | [3-(2,4-dichlorophenoxy)pr...)
Affinity DataKi:  2.90nMAssay Description:Inhibition of radioligand binding to sigma1 receptor in C57BL/6 mouse brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50559181(CHEMBL4760729)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in rat liver membranes incubated for 60 mins in presence of [3H]DTG by radioactivity metho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50001028(Talwin | PENTAZOCINE (+) | Pentazocine,(+/-) | 6,1...)
Affinity DataKi:  3.90nMAssay Description:Binding affinity to mu opioid receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  6.40nMAssay Description:Binding affinity to sigma-1 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50559176(CHEMBL4745051)
Affinity DataKi:  7.10nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain cortex membranes incubated for 120 mins by solid scintillation counting...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50559170(CHEMBL4777306)
Affinity DataKi:  8nMAssay Description:Binding affinity to sigma-1 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50559175(CHEMBL4759075)
Affinity DataKi:  9nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain cortex membranes incubated for 120 mins by solid scintillation counting...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50001028(Talwin | PENTAZOCINE (+) | Pentazocine,(+/-) | 6,1...)
Affinity DataKi:  12nMAssay Description:Binding affinity to sigma-1 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM8960(2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...)
Affinity DataKi:  15nMAssay Description:Inhibition of [3H]DTG binding to sigma 1 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50559172(T-817 maleate | T-817ma | J2.179.155E)
Affinity DataKi:  16nMAssay Description:Inhibition of (+)-pentazocine binding to human sigma 1 receptor expressed in human Jurkat cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetHistamine H3 receptor(Rat)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50559179(CHEMBL4792161)
Affinity DataKi:  23nMAssay Description:Displacement of [3H]-methylhistamine from Histamine H3 receptor in rat cerebral cortex incubated for 30 min by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50028091((1E)-5-methoxy-1-[4-(trifluoromethyl)phenyl]pentan...)
Affinity DataKi:  36nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in Sprague-Dawley rat brain membranes by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50559178(CHEMBL4763854)
Affinity DataKi:  42nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in guinea pig brain cortex membranes incubated for 120 mins by solid scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50028094((1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-te...)
Affinity DataKi:  57nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in Sprague-Dawley rat brain membranes by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM94507(SMR000326757 | Carbetapentane citrate | CHEMBL7323...)
Affinity DataKi:  76nMAssay Description:Binding affinity to muscarinic acetylcholine receptor M1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50308028(4-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine | ...)
Affinity DataKi:  82nMAssay Description:Inhibition of [3H](+)-pentazocine binding to human sigma1 receptor expressed in HEK293 cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetSigma intracellular receptor 2(Rat)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50559177(CHEMBL4760592)
Affinity DataKi:  125nMAssay Description:Displacement of [3H]DTG from sigma2 receptor in rat liver membranes incubated for 120 mins by solid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM94507(SMR000326757 | Carbetapentane citrate | CHEMBL7323...)
Affinity DataKi:  129nMAssay Description:Binding affinity to sigma-1 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetSigma intracellular receptor 2(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50559170(CHEMBL4777306)
Affinity DataKi:  152nMAssay Description:Binding affinity to sigma-2 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetSigma intracellular receptor 2(Rat)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50559185(CHEMBL4743313)
Affinity DataKi:  198nMAssay Description:Displacement of [3H]DTG from sigma 2 receptor in rat PC12 cells incubated for 120 mins in presence of [3H]-(+)-pentazocine by liquid scintillation co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetSigma intracellular receptor 2(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  221nMAssay Description:Binding affinity to sigma-2 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetSigma intracellular receptor 2(Rat)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50559180(CHEMBL4749734)
Affinity DataKi:  226nMAssay Description:Displacement of [3H]DTG from sigma2 receptor in Wistar Hannover rat liver membranes incubated for 120 mins by solid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Soochow University

Curated by ChEMBL
LigandPNGBDBM30130(Prozac | cid_62857 | Fluoxetin | CHEMBL41 | CHEMBL...)
Affinity DataKi:  240nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in Sprague-Dawley rat brain membranes by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Soochow University

Curated by ChEMBL
LigandPNGBDBM25870(CITALOPRAM HYDROBROMIDE | [3H]Escitalopram | Escit...)
Affinity DataKi:  292nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in Sprague-Dawley rat brain membranes by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50010859(CHEMBL11 | Imipramin | IMIPRAMINE HYDROCHLORIDE | ...)
Affinity DataKi:  343nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in Sprague-Dawley rat brain membranes by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
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