155 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
PMID
Data
Article Title
Organization
3-Hydrazinoindolin-2-one derivatives: Chemical classification and investigation of their targets as anticancer agents.
Egyptian Russian University
Discovery of novel, high potent, ABC type PTP1B inhibitors with TCPTP selectivity and cellular activity.
Qilu University of Technology
Design, synthesis and in vitro activity of phidianidine B derivatives as novel PTP1B inhibitors with specific selectivity.
Shanghai Institute of Materia Medica
Novel, potent, selective and cellular active ABC type PTP1B inhibitors containing (methanesulfonyl-phenyl-amino)-acetic acid methyl ester phosphotyrosine mimetic.
Qilu University of Technology
Exploring the Existing Drug Space for Novel pTyr Mimetic and SHP2 Inhibitors.
Indiana University School of Medicine
Discovery of novel, potent, selective and cellular active ADC type PTP1B inhibitors via fragment-docking-oriented de novel design.
Qilu University of Technology
Perspective: Tyrosine phosphatases as novel targets for antiplatelet therapy.
Sanford-Burnham Medical Research Institute
A potent and selective inhibitor for the UBLCP1 proteasome phosphatase.
Indiana University
Design and synthesis of novel 1,2-dithiolan-4-yl benzoate derivatives as PTP1B inhibitors.
Chinese Academy of Sciences
Synthesis and biological evaluation of open-chain analogs of cyclic peptides as inhibitors of cellular Shp2 activity.
Hebei University of Science & Technology
Synthesis and biological evaluation of novel thiadiazole amides as potent Cdc25B and PTP1B inhibitors.
Liaoning Normal University
Therapeutic potential of targeting the oncogenic SHP2 phosphatase.
Indiana University School of Medicine
Design, synthesis, and biological evaluation of novel 2-ethyl-5-phenylthiazole-4-carboxamide derivatives as protein tyrosine phosphatase 1B inhibitors with improved cellular efficacy.
Chinese Academy of Sciences
Calix[4]arene methylenebisphosphonic acids as inhibitors of protein tyrosine phosphatase 1B.
National Academy of Sciences of Ukraine
Identification of cryptotanshinone as an inhibitor of oncogenic protein tyrosine phosphatase SHP2 (PTPN11).
Case Western Reserve University
The first synthesis of natural disulfide bruguiesulfurol and biological evaluation of its derivatives as a novel scaffold for PTP1B inhibitors.
Chinese Academy of Sciences
A potent and selective small-molecule inhibitor for the lymphoid-specific tyrosine phosphatase (LYP), a target associated with autoimmune diseases.
Indiana University School of Medicine
Design, synthesis and insulin-sensitising effects of novel PTP1B inhibitors.
Peking Union Medical College
Discovery and evaluation of novel inhibitors of mycobacterium protein tyrosine phosphatase B from the 6-Hydroxy-benzofuran-5-carboxylic acid scaffold.
Indiana University School of Medicine
Bromophenols as inhibitors of protein tyrosine phosphatase 1B with antidiabetic properties.
Chinese Academy of Sciences
Bicyclic benzofuran and indole-based salicylic acids as protein tyrosine phosphatase inhibitors.
Indiana University
Identification and characterization of novel inhibitors of mPTPB, an essential virulent phosphatase from Mycobacterium tuberculosis.
Indiana University School of Medicine
Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases.
Indiana University School of Medicine
Structure of protein tyrosine phosphatase 1B in complex with inhibitors bearing two phosphotyrosine mimetics.
University of Waterloo
Exploration ofa-aminophosphonate N-derivatives as novel, potent and selective inhibitors of protein tyrosine phosphatases.
Shanxi University
Click to a focused library of benzyl 6-triazolo(hydroxy)benzoic glucosides: novel construction of PTP1B inhibitors on a sugar scaffold.
East China University of Science and Technology
Small molecule inhibitors of SHP2 tyrosine phosphatase discovered by virtual screening.
Indiana University
Facile fabrication of promising protein tyrosine phosphatase (PTP) inhibitor entities based on 'clicked' serine/threonine-monosaccharide hybrids.
East China University of Science and Technology
Using small molecules to target protein phosphatases.
Max Planck Institute of Molecular Physiology
A unique and rapid approach toward the efficient development of novel protein tyrosine phosphatase (PTP) inhibitors based on 'clicked' pseudo-glycopeptides.
East China University of Science and Technology
Shp2 protein tyrosine phosphatase inhibitor activity of estramustine phosphate and its triterpenoid analogs.
H. Lee Moffitt Cancer Center and Research Institute
Discovery and structural optimization of pyrazole derivatives as novel inhibitors of Cdc25B.
Chinese Academy of Sciences
Isolation of the protein tyrosine phosphatase 1B inhibitory metabolite from the marine-derived fungus Cosmospora sp. SF-5060.
Silla University
Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2).
Indiana University School of Medicine
Synthesis and biological evaluation of heterocyclic ring-substituted maslinic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B.
East China Normal University
Discovery of 5-Azaquinoxaline Derivatives as Potent and Orally Bioavailable Allosteric SHP2 Inhibitors.
Pfizer
Novel Pyrazolopyrazine Compounds as SHP2 Inhibitors for Treating Glioblastoma.
Smith, Gambrell & Russell
Identification of GDC-1971 (RLY-1971), a SHP2 Inhibitor Designed for the Treatment of Solid Tumors.
Relay Therapeutics
Identification of a Novel, Potent, and Orally Bioavailable Guanidine-Based SHP2 Allosteric Inhibitor from Virtual Screening and Rational Structural Optimization for the Treatment of KRAS Mutant Cancers.
China Pharmaceutical University
An adamantyl-substituted retinoid-derived molecule that inhibits cancer cell growth and angiogenesis by inducing apoptosis and binds to small heterodimer partner nuclear receptor: effects of modifying its carboxylate group on apoptosis, proliferation, and protein-tyrosine phosphatase activity.
Burnham Institute For Medical Research
Discovery of a potent and selective allosteric inhibitor targeting the SHP2 tunnel site for RTK-driven cancer treatment.
Hangzhou Medical College
Design and synthesis of improved active-site SHP2 inhibitors with anti-breast cancer cell effects.
West Virginia University
If small molecules immunotherapy comes, can the prime be far behind?
Zhejiang University
Medicinal chemistry strategies for the development of protein tyrosine phosphatase SHP2 inhibitors and PROTAC degraders.
Zhengzhou University
Therapeutic potential of targeting SHP2 in human developmental disorders and cancers.
Zhejiang University
Discovery of a Novel Series of Imidazopyrazine Derivatives as Potent SHP2 Allosteric Inhibitors.
IRBM
Brunsvicamides A-C: sponge-related cyanobacterial peptides with Mycobacterium tuberculosis protein tyrosine phosphatase inhibitory activity.
University of Bonn
Recent advances in the discovery of protein tyrosine phosphatase SHP2 inhibitors.
Soochow University
Structure-Based Design of Active-Site-Directed, Highly Potent, Selective, and Orally Bioavailable Low-Molecular-Weight Protein Tyrosine Phosphatase Inhibitors.
Eli Lilly
Discovery of a Novel Src Homology-2 Domain Containing Protein Tyrosine Phosphatase-2 (SHP2) and Cyclin-Dependent Kinase 4 (CDK4) Dual Inhibitor for the Treatment of Triple-Negative Breast Cancer.
China Pharmaceutical University
Structure-based design, synthesis and biological evaluation of aminopyrazines as highly potent, selective, and cellularly active allosteric SHP2 inhibitors.
Zhengzhou University
Strategies Targeting Protein Tyrosine Phosphatase SHP2 for Cancer Therapy.
Zhengzhou University
Discovery of Novel Src Homology-2 Domain-Containing Phosphatase 2 and Histone Deacetylase Dual Inhibitors with Potent Antitumor Efficacy and Enhanced Antitumor Immunity.
Shandong University
Targeting SHP2 as a therapeutic strategy for inflammatory diseases.
Shenyang Pharmaceutical University
Targeting Oncogenic Src Homology 2 Domain-Containing Phosphatase 2 (SHP2) by Inhibiting Its Protein-Protein Interactions.
University of Rome Tor Vergata
Discovery of thalidomide-based PROTAC small molecules as the highly efficient SHP2 degraders.
Chinese Academy of Sciences
Identification of a novel class of orally active pyrimido[5,4-3][1,2,4]triazine-5,7-diamine-based hypoglycemic agents with protein tyrosine phosphatase inhibitory activity.
Roche Research Center
Discovery and SAR of novel, potent and selective protein tyrosine phosphatase 1B inhibitors.
Abbott Laboratories
Synthesis and biological evaluation of geniposide derivatives as potent and selective PTPlB inhibitors.
Shanghai Jiao Tong University
Inhibition of Low Molecular Weight Protein Tyrosine Phosphatase by an Induced-Fit Mechanism.
Purdue University
From Pyrazolones to Azaindoles: Evolution of Active-Site SHP2 Inhibitors Based on Scaffold Hopping and Bioisosteric Replacement.
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Recent Advances of SHP2 Inhibitors in Cancer Therapy: Current Development and Clinical Application.
China Pharmaceutical University
Synthesis and biological evaluation of heterocyclic bis-aryl amides as novel Src homology 2 domain containing protein tyrosine phosphatase-2 (SHP2) inhibitors.
Jiangnan University
Discovery of SHP2-D26 as a First, Potent, and Effective PROTAC Degrader of SHP2 Protein.
TBA
Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor.
Novartis Institutes For Biomedical Research
Allosteric Modulation of Phosphatase Activity May Redefine Therapeutic Value.
University of Pittsburgh
Calixarene-based phosphinic acids as inhibitors of protein tyrosine phosphatases.
V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of The National Academy of Sciences of Ukraine
Investigation of stereoisomeric bisarylethenesulfonic acid esters for discovering potent and selective PTP1B inhibitors.
Shanghai Jiao Tong University (Sjtu)
Small Molecule Inhibitor that Stabilizes the Autoinhibited Conformation of the Oncogenic Tyrosine Phosphatase SHP2.
Emory University School of Medicine
Synthesis and PTP Inhibitory Activity of Illudalic Acid and Its Methyl Ether, with Insights into Selectivity for LAR PTP over Other Tyrosine Phosphatases under Physiologically Relevant Conditions.
University of Utah
6-Amino-3-methylpyrimidinones as Potent, Selective, and Orally Efficacious SHP2 Inhibitors.
TBA
Toward a treatment of diabesity: In vitro and in vivo evaluation of uncharged bromophenol derivatives as a new series of PTP1B inhibitors.
Chinese Academy of Sciences
Diketopiperazine-Type Alkaloids from a Deep-Sea-Derived Aspergillus puniceus Fungus and Their Effects on Liver X Receptor α.
Chinese Academy of Sciences
Celastrol Promotes Weight Loss in Diet-Induced Obesity by Inhibiting the Protein Tyrosine Phosphatases PTP1B and TCPTP in the Hypothalamus.
Helmholtz Zentrum M�Nchen
Synthesis and biological evaluation of tryptophan-derived rhodanine derivatives as PTP1B inhibitors and anti-bacterial agents.
Yanbian University College of Pharmacy
Development and structure-activity relationship study of SHP2 inhibitor containing 3,4,6-trihydroxy-5-oxo-5H-benzo[7]annulene.
Chungnam University
Potent antagonists of the SH2 domain of Grb2: optimization of the X+1 position of 3-amino-Z-Tyr(PO3H2)-X+1-Asn-NH2.
Novartis Pharma
Discovery of 1,3-diphenyl-1H-pyrazole derivatives containing rhodanine-3-alkanoic acid groups as potential PTP1B inhibitors.
Yanbian University
Diversity-Oriented Synthesis for Novel, Selective and Drug-like Inhibitors for a Phosphatase from Mycobacterium Tuberculosis.
Indiana University School of Medicine
L-O-(2-malonyl)tyrosine: a new phosphotyrosyl mimetic for the preparation of Src homology 2 domain inhibitory peptides.
National Cancer Institute-Bethesda
Study of triaryl-based sulfamic acid derivatives as HPTPβ inhibitors.
National Engineering Research Center For The Emergency Strategic Drug
Benzo[c][1,2,5]thiadiazole derivatives: A new class of potent Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) inhibitors.
Jiangnan University
Identification of an allosteric benzothiazolopyrimidone inhibitor of the oncogenic protein tyrosine phosphatase SHP2.
Harvard Medical School
Discovery of novel high potent and cellular active ADC type PTP1B inhibitors with selectivity over TC-PTP via modification interacting with C site.
Qilu University of Technology
Varic acid analogues from fungus as PTP1B inhibitors: Biological evaluation and structure-activity relationships.
Dalian University of Technology
Y-shaped bis-arylethenesulfonic acid esters: Potential potent and membrane permeable protein tyrosine phosphatase 1B inhibitors.
Shanghai Jiao Tong University
Allosteric Inhibitors of SHP2 with Therapeutic Potential for Cancer Treatment.
Chinese Academy of Sciences
Discovery and evaluation of the hybrid of bromophenol and saccharide as potent and selective protein tyrosine phosphatase 1B inhibitors.
Chinese Academy of Sciences
CELL-POTENT BISUBSTRATE INHIBITORS FOR NICOTINAMIDE N-METHYLTRANSFERASE (NNMT) AND USES THEREOF
Purdue Research Foundation
Pyrazolo[3,4-b]pyrazine SHP2 phosphatase inhibitors and methods of use thereof
Relay Therapeutics
HETEROAROYL AMIDES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF
Merck Sharp & Dohme
CARBONYL HETEROCYCLIC COMPOUND AND APPLICATION THEREOF
Shanghai Pharmaceuticals Holding Co.
SMALL MOLECULE INHIBITOR FOR CATHEPSIN C AND MEDICINAL USE THEREOF
Reistone Biopharma Company
Substituted pyrrolo[2,3-d]pyrimidines and pyrazolo[3,4-d]pyrimidines as inhibitors for multi-resistant cancers
Ferris State University
Compounds for the modulation of cyclophilins function
The University Court of The University of Edinburgh
Compound having KDM5 inhibitory activity and pharmaceutical use thereof
Ono Pharmaceutical
2-[thiophen-2-yl)formamido]-N-(phenyl)-2-methylpropanamide derivatives and the use thereof as medicament
Boehringer Ingelheim International
Fluorinated tetrahydronaphthyridinyl nonanoic acid derivatives and uses thereof
Ocuterra Therapeutics
Disubstituted octahydropyrrolo[3,4-c]pyrroles as orexin receptor modulators
Janssen Pharmaceutica
3-triazolyl methyl-1,3,5-triazine-2,4-dione compounds and preparation method and application thereof
Shaanxi Panlong Pharmaceutical
Aromatic heterocyclic compound, intermediate thereof, preparation method therefor, and pharmaceutical composition and use thereof
Shanghai Yingli Pharmaceutical
Substituted diamino heterocyclic carboxamide compound and a composition containing the compound and use thereof
Shenzhen Targetrx
Receptor inhibitor, pharmaceutical composition comprising same, and use thereof
Beijing Tide Pharmaceutical
Cycloalkyl-containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
Enanta Pharmaceuticals
Carbazole-containing amides, carbamates, and ureas as cryptochrome modulators
Synchronicity Pharma
Disubstituted oxazolidin-2-ones 5-hydroxytryptamine receptor 2B activity modulators
Temple University
2,4-diamino-6,7-dihydro-5H-pyrrolo[2,3]pyrimidine derivatives as FAK/Pyk2 inhibitors
Centaurus Biopharma
Dihydropyrimidine based hydrazine dihydrochloride derivatives as potent urease inhibitors.
University of Karachi
A small molecule screen identifies selective inhibitors of urea transporter UT-A.
University of California San Francisco
Biochemical characterization of the cellular glycosylphosphatidylinositol-linked membrane type-6 matrix metalloproteinase.
Sanford-Burnham Medical Research Institute
Ligand-directed functional heterogeneity of histamine H1 receptors: novel dual-function ligands selectively activate and block H1-mediated phospholipase C and adenylyl cyclase signaling.
University of North Carolina At Chapel Hill
Ligand specificity of nicotinic acetylcholine receptors in rat spinal cord: studies with nicotine and cytisine.
University of California