Compile Data Set for Download or QSAR
Report error Found 40 Enz. Inhib. hit(s) with all data for entry = 50020154
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50626861(CHEMBL5440998)
Affinity DataIC50: 89nMAssay Description:Inhibition of pIRS-1 peptide activated human wild type SHP2 FL (Met1 to Leu525 residues) using DiFMUP as substrate preincubated for 30 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM38019(US10093646, Compound 1 | US10301278, Example 00003...)
Affinity DataIC50: 89nMAssay Description:Inhibition of pIRS-1 peptide activated human wild type SHP2 FL (Met1 to Leu525 residues) using DiFMUP as substrate preincubated for 30 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50626891(CHEMBL5420523)
Affinity DataIC50: 250nMAssay Description:Inhibition of pIRS-1 peptide activated human wild type SHP2 FL (Met1 to Leu525 residues) using DiFMUP as substrate preincubated for 30 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50626861(CHEMBL5440998)
Affinity DataIC50: 590nMAssay Description:Inhibition of human SHP2 in human NCI-H1975 cells assessed as reduction in ERK phosphorylation by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50626890(CHEMBL5402768)
Affinity DataIC50: 620nMAssay Description:Inhibition of pIRS-1 peptide activated human wild type SHP2 FL (Met1 to Leu525 residues) using DiFMUP as substrate preincubated for 30 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50626861(CHEMBL5440998)
Affinity DataIC50: 630nMAssay Description:Inhibition of human SHP2 in human NCI-H1975/OSIR cells assessed as reduction in ERK phosphorylation by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50626894(CHEMBL5429374)
Affinity DataIC50: 800nMAssay Description:Inhibition of pIRS-1 peptide activated human wild type SHP2 FL (Met1 to Leu525 residues) using DiFMUP as substrate preincubated for 30 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50626876(CHEMBL5432231)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of pIRS-1 peptide activated human wild type SHP2 FL (Met1 to Leu525 residues) using DiFMUP as substrate preincubated for 30 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50626886(CHEMBL5412187)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of pIRS-1 peptide activated human wild type SHP2 FL (Met1 to Leu525 residues) using DiFMUP as substrate preincubated for 30 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50626889(CHEMBL5415939)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of pIRS-1 peptide activated human wild type SHP2 FL (Met1 to Leu525 residues) using DiFMUP as substrate preincubated for 30 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50626877(CHEMBL4964870)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of pIRS-1 peptide activated human wild type SHP2 FL (Met1 to Leu525 residues) using DiFMUP as substrate preincubated for 30 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50626887(CHEMBL5436317)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of pIRS-1 peptide activated human wild type SHP2 FL (Met1 to Leu525 residues) using DiFMUP as substrate preincubated for 30 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50626892(CHEMBL5402012)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of pIRS-1 peptide activated human wild type SHP2 FL (Met1 to Leu525 residues) using DiFMUP as substrate preincubated for 30 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50626873(CHEMBL5408793)
Affinity DataIC50: 5.60E+3nMAssay Description:Inhibition of pIRS-1 peptide activated human wild type SHP2 FL (Met1 to Leu525 residues) using DiFMUP as substrate preincubated for 30 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50626868(CHEMBL5419682)
Affinity DataIC50: 5.60E+3nMAssay Description:Inhibition of pIRS-1 peptide activated human wild type SHP2 FL (Met1 to Leu525 residues) using DiFMUP as substrate preincubated for 30 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50626864(CHEMBL5440810)
Affinity DataIC50: 6.70E+3nMAssay Description:Inhibition of pIRS-1 peptide activated human wild type SHP2 FL (Met1 to Leu525 residues) using DiFMUP as substrate preincubated for 30 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50626883(CHEMBL5437682)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of pIRS-1 peptide activated human wild type SHP2 FL (Met1 to Leu525 residues) using DiFMUP as substrate preincubated for 30 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50626893(CHEMBL5407666)
Affinity DataIC50: 8.10E+3nMAssay Description:Inhibition of pIRS-1 peptide activated human wild type SHP2 FL (Met1 to Leu525 residues) using DiFMUP as substrate preincubated for 30 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50626865(CHEMBL5408509)
Affinity DataIC50: 8.50E+3nMAssay Description:Inhibition of pIRS-1 peptide activated human wild type SHP2 FL (Met1 to Leu525 residues) using DiFMUP as substrate preincubated for 30 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50626863(CHEMBL5433590)
Affinity DataIC50: 9.30E+3nMAssay Description:Inhibition of pIRS-1 peptide activated human wild type SHP2 FL (Met1 to Leu525 residues) using DiFMUP as substrate preincubated for 30 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50626874(CHEMBL4986224)
Affinity DataIC50: 9.50E+3nMAssay Description:Inhibition of pIRS-1 peptide activated human wild type SHP2 FL (Met1 to Leu525 residues) using DiFMUP as substrate preincubated for 30 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50626859(CHEMBL4912763)
Affinity DataIC50: 1.02E+4nMAssay Description:Inhibition of pIRS-1 peptide activated human wild type SHP2 FL (Met1 to Leu525 residues) using DiFMUP as substrate preincubated for 30 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50626862(CHEMBL5411096)
Affinity DataIC50: 1.15E+4nMAssay Description:Inhibition of pIRS-1 peptide activated human wild type SHP2 FL (Met1 to Leu525 residues) using DiFMUP as substrate preincubated for 30 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50626888(CHEMBL5425577)
Affinity DataIC50: 1.25E+4nMAssay Description:Inhibition of pIRS-1 peptide activated human wild type SHP2 FL (Met1 to Leu525 residues) using DiFMUP as substrate preincubated for 30 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50626875(CHEMBL4915881)
Affinity DataIC50: 1.28E+4nMAssay Description:Inhibition of pIRS-1 peptide activated human wild type SHP2 FL (Met1 to Leu525 residues) using DiFMUP as substrate preincubated for 30 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50626858(CHEMBL1897231)
Affinity DataIC50: 1.35E+4nMAssay Description:Inhibition of pIRS-1 peptide activated human wild type SHP2 FL (Met1 to Leu525 residues) using DiFMUP as substrate preincubated for 30 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50626860(CHEMBL5401524)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of pIRS-1 peptide activated human wild type SHP2 FL (Met1 to Leu525 residues) using DiFMUP as substrate preincubated for 30 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50626880(CHEMBL5411139)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of pIRS-1 peptide activated human wild type SHP2 FL (Met1 to Leu525 residues) using DiFMUP as substrate preincubated for 30 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50626866(CHEMBL5394227)
Affinity DataIC50: 3.50E+4nMAssay Description:Inhibition of pIRS-1 peptide activated human wild type SHP2 FL (Met1 to Leu525 residues) using DiFMUP as substrate preincubated for 30 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50626879(CHEMBL5432065)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of pIRS-1 peptide activated human wild type SHP2 FL (Met1 to Leu525 residues) using DiFMUP as substrate preincubated for 30 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50626882(CHEMBL5407386)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of pIRS-1 peptide activated human wild type SHP2 FL (Met1 to Leu525 residues) using DiFMUP as substrate preincubated for 30 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50626885(CHEMBL5414852)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of pIRS-1 peptide activated human wild type SHP2 FL (Met1 to Leu525 residues) using DiFMUP as substrate preincubated for 30 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50626884(CHEMBL5408771)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of pIRS-1 peptide activated human wild type SHP2 FL (Met1 to Leu525 residues) using DiFMUP as substrate preincubated for 30 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50626881(CHEMBL5427461)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of pIRS-1 peptide activated human wild type SHP2 FL (Met1 to Leu525 residues) using DiFMUP as substrate preincubated for 30 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50626878(CHEMBL5433569)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of pIRS-1 peptide activated human wild type SHP2 FL (Met1 to Leu525 residues) using DiFMUP as substrate preincubated for 30 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50626867(CHEMBL5430873)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of pIRS-1 peptide activated human wild type SHP2 FL (Met1 to Leu525 residues) using DiFMUP as substrate preincubated for 30 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50626872(CHEMBL5417621)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of pIRS-1 peptide activated human wild type SHP2 FL (Met1 to Leu525 residues) using DiFMUP as substrate preincubated for 30 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50626871(CHEMBL5438401)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of pIRS-1 peptide activated human wild type SHP2 FL (Met1 to Leu525 residues) using DiFMUP as substrate preincubated for 30 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50626870(CHEMBL5402629)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of pIRS-1 peptide activated human wild type SHP2 FL (Met1 to Leu525 residues) using DiFMUP as substrate preincubated for 30 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50626869(CHEMBL5411145)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of pIRS-1 peptide activated human wild type SHP2 FL (Met1 to Leu525 residues) using DiFMUP as substrate preincubated for 30 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed