Compile Data Set for Download or QSAR
Report error Found 12 Enz. Inhib. hit(s) with all data for entry = 50011647
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM497144(US11001561, Compound 119a | US11702392, Compound 1...)
Affinity DataIC50: 0.800nMAssay Description:Antagonist activity at recombinant human N-terminal His6-tagged full length SHP2 expressed in Escherichia coli using DiFMUP as substrate measured aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM497078(US11001561, Compound 66b | US11702392, Compound 66...)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at recombinant human N-terminal His6-tagged full length SHP2 expressed in Escherichia coli using DiFMUP as substrate measured aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM497131(US11001561, Compound 106)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at recombinant human N-terminal His6-tagged full length SHP2 expressed in Escherichia coli using DiFMUP as substrate measured aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM497106(US11001561, Compound 81b | US11702392, Compound 81...)
Affinity DataIC50: 1.40nMAssay Description:Antagonist activity at recombinant human N-terminal His6-tagged full length SHP2 expressed in Escherichia coli using DiFMUP as substrate measured aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM497134(US11001561, Compound 109 | US11702392, Compound 10...)
Affinity DataIC50: 2nMAssay Description:Antagonist activity at recombinant human N-terminal His6-tagged full length SHP2 expressed in Escherichia coli using DiFMUP as substrate measured aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM497135(US11001561, Compound 110 | US11702392, Compound 11...)
Affinity DataIC50: 2nMAssay Description:Antagonist activity at recombinant human N-terminal His6-tagged full length SHP2 expressed in Escherichia coli using DiFMUP as substrate measured aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM497131(US11001561, Compound 106)
Affinity DataIC50: 2nMAssay Description:Antagonist activity at SHP2 in human KYSE520 cells assessed as inhibition of ERK1/2 phosphorylation incubated for 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM497134(US11001561, Compound 109 | US11702392, Compound 10...)
Affinity DataIC50: 4nMAssay Description:Antagonist activity at SHP2 in human KYSE520 cells assessed as inhibition of ERK1/2 phosphorylation incubated for 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM497078(US11001561, Compound 66b | US11702392, Compound 66...)
Affinity DataIC50: 5nMAssay Description:Antagonist activity at SHP2 in human KYSE520 cells assessed as inhibition of ERK1/2 phosphorylation incubated for 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM497144(US11001561, Compound 119a | US11702392, Compound 1...)
Affinity DataIC50: 5nMAssay Description:Antagonist activity at SHP2 in human KYSE520 cells assessed as inhibition of ERK1/2 phosphorylation incubated for 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM497106(US11001561, Compound 81b | US11702392, Compound 81...)
Affinity DataIC50: 6.60nMAssay Description:Antagonist activity at SHP2 in human KYSE520 cells assessed as inhibition of ERK1/2 phosphorylation incubated for 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM497135(US11001561, Compound 110 | US11702392, Compound 11...)
Affinity DataIC50: 7nMAssay Description:Antagonist activity at SHP2 in human KYSE520 cells assessed as inhibition of ERK1/2 phosphorylation incubated for 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed