Compile Data Set for Download or QSAR
Report error Found 21 Enz. Inhib. hit(s) with all data for entry = 50031153
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50308158(3-{1-[3-(biphenyl-4-ylamino)-3-oxopropyl]-1H-1,2,3...)
Affinity DataIC50: 5.50E+3nMpH: 7.0Assay Description:Inhibition of SHP2 Src homology-2 domain expressed in Escherichia coli BL21 (DE3) assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50308159(6-hydroxy-1-methyl-3-(1-(2-(4-morpholinophenylamin...)
Affinity DataIC50: 7.80E+3nMpH: 7.0Assay Description:Inhibition of SHP2 Src homology-2 domain expressed in Escherichia coli BL21 (DE3) assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50308162(6-hydroxy-1-methyl-3-(1-(5-oxo-5-(10H-phenothiazin...)
Affinity DataIC50: 8.00E+3nMpH: 7.0Assay Description:Inhibition of SHP2 Src homology-2 domain expressed in Escherichia coli BL21 (DE3) assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50308161(3-(1-(2-(benzo[d]thiazol-2-ylamino)-2-oxoethyl)-1H...)
Affinity DataIC50: 9.10E+3nMpH: 7.0Assay Description:Inhibition of SHP2 Src homology-2 domain expressed in Escherichia coli BL21 (DE3) assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50308164(3-(1-(2-(biphenyl-4-ylamino)-2-oxoethyl)-1H-1,2,3-...)
Affinity DataIC50: 9.30E+3nMpH: 7.0Assay Description:Inhibition of SHP2 Src homology-2 domain expressed in Escherichia coli BL21 (DE3) assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50308160(3-(1-(2-(9H-fluoren-9-ylamino)-2-oxoethyl)-1H-1,2,...)
Affinity DataIC50: 1.04E+4nMpH: 7.0Assay Description:Inhibition of SHP2 Src homology-2 domain expressed in Escherichia coli BL21 (DE3) assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50308165(3-(1-(4-(biphenyl-4-ylamino)-4-oxobutyl)-1H-1,2,3-...)
Affinity DataIC50: 1.20E+4nMpH: 7.0Assay Description:Inhibition of SHP2 Src homology-2 domain expressed in Escherichia coli BL21 (DE3) assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50308158(3-{1-[3-(biphenyl-4-ylamino)-3-oxopropyl]-1H-1,2,3...)
Affinity DataIC50: 1.43E+4nMpH: 7.0Assay Description:Inhibition of PTP1B expressed in Escherichia coli assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH 7 by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50308158(3-{1-[3-(biphenyl-4-ylamino)-3-oxopropyl]-1H-1,2,3...)
Affinity DataIC50: 1.57E+4nMpH: 7.0Assay Description:Inhibition of SHP1 expressed in Escherichia coli assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH 7 by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 13(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50308158(3-{1-[3-(biphenyl-4-ylamino)-3-oxopropyl]-1H-1,2,3...)
Affinity DataIC50: 2.03E+4nMpH: 7.0Assay Description:Inhibition of FAP1 expressed in Escherichia coli assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH 7 by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 22(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50308158(3-{1-[3-(biphenyl-4-ylamino)-3-oxopropyl]-1H-1,2,3...)
Affinity DataIC50: 2.50E+4nMpH: 7.0Assay Description:Inhibition of Lyp expressed in Escherichia coli assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH 7 by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase C(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50308158(3-{1-[3-(biphenyl-4-ylamino)-3-oxopropyl]-1H-1,2,3...)
Affinity DataIC50: 3.00E+4nMpH: 7.0Assay Description:Inhibition of CD45 expressed in Escherichia coli assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH 7 by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetLow molecular weight phosphotyrosine protein phosphatase(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50308158(3-{1-[3-(biphenyl-4-ylamino)-3-oxopropyl]-1H-1,2,3...)
Affinity DataIC50: 3.11E+4nMpH: 7.0Assay Description:Inhibition of LMWPTP expressed in Escherichia coli assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH 7 by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetDual specificity protein phosphatase 3(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50308158(3-{1-[3-(biphenyl-4-ylamino)-3-oxopropyl]-1H-1,2,3...)
Affinity DataIC50: 5.00E+4nMpH: 7.0Assay Description:Inhibition of VHR expressed in Escherichia coli assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH 7 by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase alpha(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50308158(3-{1-[3-(biphenyl-4-ylamino)-3-oxopropyl]-1H-1,2,3...)
Affinity DataIC50: 5.00E+4nMpH: 7.0Assay Description:Inhibition of PTPalpha expressed in Escherichia coli assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH 7 by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase F(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50308158(3-{1-[3-(biphenyl-4-ylamino)-3-oxopropyl]-1H-1,2,3...)
Affinity DataIC50: 5.00E+4nMpH: 7.0Assay Description:Inhibition of LAR expressed in Escherichia coli assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH 7 by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 7(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50308158(3-{1-[3-(biphenyl-4-ylamino)-3-oxopropyl]-1H-1,2,3...)
Affinity DataIC50: 5.00E+4nMpH: 7.0Assay Description:Inhibition of HePTP expressed in Escherichia coli assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH 7 by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetDual specificity protein phosphatase CDC14A(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50308158(3-{1-[3-(biphenyl-4-ylamino)-3-oxopropyl]-1H-1,2,3...)
Affinity DataIC50: 5.00E+4nMpH: 7.0Assay Description:Inhibition of Cdc14A expressed in Escherichia coli assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH 7 by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50308166(6-hydroxy-1-methyl-3-(1-(3-oxo-3-(phenylamino)prop...)
Affinity DataIC50: 8.60E+4nMpH: 7.0Assay Description:Inhibition of SHP2 Src homology-2 domain expressed in Escherichia coli BL21 (DE3) assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50308163(3-Ethynyl-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-...)
Affinity DataIC50: 2.12E+5nMpH: 7.0Assay Description:Inhibition of SHP2 Src homology-2 domain expressed in Escherichia coli BL21 (DE3) assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50308158(3-{1-[3-(biphenyl-4-ylamino)-3-oxopropyl]-1H-1,2,3...)
Affinity DataKi:  5.20E+3nMAssay Description:Inhibition of SHP2 Src homology-2 domain expressed in Escherichia coli BL21 (DE3) assessed as inhibition of p-nitrophenyl phosphate hydrolysis by Lin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed