Compile Data Set for Download or QSAR
Report error Found 16 Enz. Inhib. hit(s) with all data for entry = 50020372
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM484868(US10934302, Example 119)
Affinity DataIC50: 1nMAssay Description:Inhibition of wild-type full-length SHP2 (unknown origin) expressed in Escherichia coli BL21(DE3) using DiFMUP as substrate preincubated for 30 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM484776(US10934302, Example 25)
Affinity DataIC50: 1nMAssay Description:Inhibition of wild-type full-length SHP2 (unknown origin) expressed in Escherichia coli BL21(DE3) using DiFMUP as substrate preincubated for 30 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM50629390(CHEMBL5430267)
Affinity DataIC50: 3nMAssay Description:Inhibition of wild-type full-length SHP2 (unknown origin) expressed in Escherichia coli BL21(DE3) using DiFMUP as substrate preincubated for 30 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM484765(US10934302, Example 14)
Affinity DataIC50: 3nMAssay Description:Inhibition of wild-type full-length SHP2 (unknown origin) expressed in Escherichia coli BL21(DE3) using DiFMUP as substrate preincubated for 30 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM596097(US11591336, Compound 200)
Affinity DataIC50: 5nMAssay Description:Inhibition of wild-type full-length SHP2 (unknown origin) expressed in Escherichia coli BL21(DE3) using DiFMUP as substrate preincubated for 30 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM600647(US11629145, Compound 41)
Affinity DataIC50: 10nMAssay Description:Inhibition of wild-type full-length SHP2 (unknown origin) expressed in Escherichia coli BL21(DE3) using DiFMUP as substrate preincubated for 30 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM484862(US10934302, Example 113)
Affinity DataIC50: 13nMAssay Description:Inhibition of wild-type full-length SHP2 (unknown origin) expressed in Escherichia coli BL21(DE3) using DiFMUP as substrate preincubated for 30 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM384117(US10280171, Example 1 | 1-(3-(2,3-dichlorophenyl)-...)
Affinity DataIC50: 18nMAssay Description:Inhibition of wild-type full-length SHP2 (unknown origin) expressed in Escherichia coli BL21(DE3) using DiFMUP as substrate preincubated for 30 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM595944(US11629145, Compound 86 | US11591336, Compound 41)
Affinity DataIC50: 31nMAssay Description:Inhibition of wild-type full-length SHP2 (unknown origin) expressed in Escherichia coli BL21(DE3) using DiFMUP as substrate preincubated for 30 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM595804(US11629145, Compound 8 | US11591336, Compound 6)
Affinity DataIC50: 38nMAssay Description:Inhibition of wild-type full-length SHP2 (unknown origin) expressed in Escherichia coli BL21(DE3) using DiFMUP as substrate preincubated for 30 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM595892(US11629145, Compound 73 | US11591336, Compound 28)
Affinity DataIC50: 41nMAssay Description:Inhibition of wild-type full-length SHP2 (unknown origin) expressed in Escherichia coli BL21(DE3) using DiFMUP as substrate preincubated for 30 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM596290(US11591336, Compound 494)
Affinity DataIC50: 100nMAssay Description:Inhibition of wild-type full-length SHP2 (unknown origin) expressed in Escherichia coli BL21(DE3) using DiFMUP as substrate preincubated for 30 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM384140(US10280171, Example 26 | 1-(3-(3-chloro-2- fluorop...)
Affinity DataIC50: 120nMAssay Description:Inhibition of wild-type full-length SHP2 (unknown origin) expressed in Escherichia coli BL21(DE3) using DiFMUP as substrate preincubated for 30 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM595872(US11629145, Compound 68 | US11591336, Compound 23)
Affinity DataIC50: 130nMAssay Description:Inhibition of wild-type full-length SHP2 (unknown origin) expressed in Escherichia coli BL21(DE3) using DiFMUP as substrate preincubated for 30 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM484868(US10934302, Example 119)
Affinity DataIC50: 170nMAssay Description:Inhibition of full-length SHP2 E76K mutant (unknown origin) expressed in Escherichia coli BL21(DE3) using DiFMUP as substrate preincubated for 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM50629391(CHEMBL5426862)
Affinity DataIC50: 310nMAssay Description:Inhibition of wild-type full-length SHP2 (unknown origin) expressed in Escherichia coli BL21(DE3) using DiFMUP as substrate preincubated for 30 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed