104 articles for thisTarget
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Discovery of an Orally Selective Inhibitor of Signal Transducer and Activator of Transcription 3 Using Advanced Multiple Ligand Simultaneous Docking.
The Ohio State University
4-Carbonyl-2,6-dibenzylidenecyclohexanone derivatives as small molecule inhibitors of STAT3 signaling pathway.
Soochow University
Neuroactive and Anti-inflammatory Frankincense Cembranes: A Structure-Activity Study.
University of Eastern Piedmont
Optimization of pyrazole-containing 1,2,4-triazolo-[3,4-b]thiadiazines, a new class of STAT3 pathway inhibitors.
University of Pittsburgh
Turmeric Sesquiterpenoids: Expeditious Resolution, Comparative Bioactivity, and a New Bicyclic Turmeronoid.
University of Eastern Piedmont
Synthesis of natural phaeosphaeride A derivatives and an in vitro evaluation of their anti-cancer potential.
Research Institute of Hygiene
Novel aminotetrazole derivatives as selective STAT3 non-peptide inhibitors.
University of Franche-Comt£
Hirsutinolide Series Inhibit Stat3 Activity, Alter GCN1, MAP1B, Hsp105, G6PD, Vimentin, TrxR1, and Importina-2 Expression, and Induce Antitumor Effects against Human Glioma.
University of Hawaii At Hilo
N-Sulfonyl-aminobiaryls as Antitubulin Agents and Inhibitors of Signal Transducers and Activators of Transcription 3 (STAT3) Signaling.
Taipei Medical University
2-Guanidinoquinazolines as new inhibitors of the STAT3 pathway.
University of Pittsburgh
Isolation and Characterization of Dammarane-Type Saponins from Gynostemma pentaphyllum and Their Inhibitory Effects on IL-6-Induced STAT3 Activation.
Chungbuk National University
Nanomolar-Potency Small Molecule Inhibitor of STAT5 Protein.
University of Toronto Mississauga
SAR studies on curcumin's pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase.
University Jena
A perylene derivative regulates HIF-1a and Stat3 signaling pathways.
Baylor College of Medicine
Potent Targeting of the STAT3 Protein in Brain Cancer Stem Cells: A Promising Route for Treating Glioblastoma.
University of Toronto At Mississauga
Inhibiting aberrant signal transducer and activator of transcription protein activation with tetrapodal, small molecule Src homology 2 domain binders: promising agents against multiple myeloma.
University of Toronto Mississauga
Anticancer activity and SAR studies of substituted 1,4-naphthoquinones.
The Ohio State University
Discovery of novel STAT3 small molecule inhibitors via in silico site-directed fragment-based drug design.
The Ohio State University
Identification and characterization of small molecule inhibitors of signal transducer and activator of transcription 3 (STAT3) signaling pathway by virtual screening.
Fudan University
Discovery of novel inhibitors of signal transducer and activator of transcription 3 (STAT3) signaling pathway by virtual screening.
Fudan University
Small molecule inhibitors of signal transducer and activator of transcription 3 (Stat3) protein.
University of Southern California
Small molecule STAT5-SH2 domain inhibitors exhibit potent antileukemia activity.
University of Toronto
Identification of Purine-Scaffold Small-Molecule Inhibitors of Stat3 Activation by QSAR Studies.
TBA
Discovery of 5-chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (AZD1480) as a novel inhibitor of the Jak/Stat pathway.
Astrazeneca R&D
Cucurbitane-type triterpenoids from the stems of Cucumis melo.
Chinese Academy of Sciences
Identification of a non-phosphorylated, cell permeable, small molecule ligand for the Stat3 SH2 domain.
University of Toronto Mississauga
Potent and selective phosphopeptide mimetic prodrugs targeted to the Src homology 2 (SH2) domain of signal transducer and activator of transcription 3.
University of Texas M. D. Anderson Cancer Center
Identification of Niclosamide as a New Small-Molecule Inhibitor of the STAT3 Signaling Pathway.
TBA
Design, synthesis, and in vitro characterization of novel hybrid peptidomimetic inhibitors of STAT3 protein.
University of Toronto
5-amino-pyrazoles as potent and selective p38a inhibitors.
Bristol-Myers Squibb Research and Development
Structure-affinity relationships of glutamine mimics incorporated into phosphopeptides targeted to the SH2 domain of signal transducer and activator of transcription 3.
The University of Texas M.D. Anderson Cancer Center
Conformationally constrained peptidomimetic inhibitors of signal transducer and activator of transcription. 3: Evaluation and molecular modeling.
The University of Texas M.D. Anderson Cancer Center
Discovery of 4-(benzylaminomethylene)isoquinoline-1,3-(2H,4H)-diones and 4-[(pyridylmethyl)aminomethylene]isoquinoline-1,3-(2H,4H)-diones as potent and selective inhibitors of the cyclin-dependent kinase 4.
Wyeth Research
Discovery of the catechol structural moiety as a Stat3 SH2 domain inhibitor by virtual screening.
Wyeth Pharmaceuticals
Inhibition of the signal transducer and activator of transcription-3 (STAT3) signaling pathway by 4-oxo-1-phenyl-1,4-dihydroquinoline-3-carboxylic acid esters.
Wyeth Research
Development and Therapeutic Implications of Tyrosine Kinase 2 Inhibitors.
China Pharmaceutical University
Design, Synthesis, and Biological Activity of Marinacarboline Analogues as STAT3 Pathway Inhibitors for Docetaxel-Resistant Triple-Negative Breast Cancer.
Seoul National University
Identification and Biological Evaluation of a Potent and Selective JAK1 Inhibitor for the Treatment of Pulmonary Fibrosis.
Ewha Womans University
New syntheses of tetrazolylmethylphenylalanine and O-malonyltyrosine as pTyr mimetics for the design of STAT3 dimerization inhibitors.
Université
Dual-target Janus kinase (JAK) inhibitors: Comprehensive review on the JAK-based strategies for treating solid or hematological malignancies and immune-related diseases.
China Pharmaceutical University
Perspective for Discovery of Small Molecule IL-6 Inhibitors through Study of Structure-Activity Relationships and Molecular Docking.
Dongguk University
Eyes on Topical Ocular Disposition: The Considered Design of a Lead Janus Kinase (JAK) Inhibitor That Utilizes a Unique Azetidin-3-Amino Bridging Scaffold to Attenuate Off-Target Kinase Activity, While Driving Potency and Aqueous Solubility.
Alcon Research
Discovery, Optimization, and Evaluation of Novel
Chinese Academy of Medical Sciences & Peking Union Medical College
Solid-phase synthesis of Stat3 inhibitors incorporating O-carbamoylserine and O-carbamoylthreonine as glutamine mimics.
The University of Texas
PROTACs: New method to degrade transcription regulating proteins.
Shenyang Pharmaceutical University
Janus kinases (JAKs): The efficient therapeutic targets for autoimmune diseases and myeloproliferative disorders.
China Pharmaceutical University
Anti-inflammatory activity of naturally occuring diarylheptanoids - A review.
Universita Paul Sabatier
Allosteric inhibitors of the STAT3 signaling pathway.
West China Second University Hospital
Revisiting signal transducer and activator of transcription 3 (STAT3) as an anticancer target and its inhibitor discovery: Where are we and where should we go?
Sun Yat-Sen University
Recent Update on Development of Small-Molecule STAT3 Inhibitors for Cancer Therapy: From Phosphorylation Inhibition to Protein Degradation.
Cancer Hospital of The University of Chinese Academy of Sciences (Zhejiang Cancer Hospital)
Boronic Acid: A Novel Pharmacophore Targeting Src Homology 2 (SH2) Domain of STAT3.
Sun Yat-Sen University
Discovery of 2-Amino-3-cyanothiophene Derivatives as Potent STAT3 Inhibitors for the Treatment of Osteosarcoma Growth and Metastasis.
East China Normal University
Discovery of STAT3 and Histone Deacetylase (HDAC) Dual-Pathway Inhibitors for the Treatment of Solid Cancer.
China Pharmaceutical University
Telocinobufagin Has Antitumor Effects in Non-Small-Cell Lung Cancer by Inhibiting STAT3 Signaling.
Wenzhou Medical University
Discovery of a Novel Potent STAT3 Inhibitor HP590 with Dual p-Tyr
East China Normal University
S3I-201 derivative incorporating naphthoquinone unit as effective STAT3 inhibitors: Design, synthesis and anti-gastric cancer evaluation.
Zhejiang Chinese Medical University
Discovery of a Highly Potent and Orally Bioavailable STAT3 Dual Phosphorylation Inhibitor for Pancreatic Cancer Treatment.
East China Normal University
Recent advances of quinones as a privileged structure in drug discovery.
Jinan Second People'S Hospital
Structure-based discovery of potent and selective small-molecule inhibitors targeting signal transducer and activator of transcription 3 (STAT3).
Sun Yat-Sen University
Rational drug design of benzothiazole-based derivatives as potent signal transducer and activator of transcription 3 (STAT3) signaling pathway inhibitors.
Fudan University
Discovery of N-substituted sulfamoylbenzamide derivatives as novel inhibitors of STAT3 signaling pathway based on Niclosamide.
The First Affiliated Hospital of Wenzhou Medical University
Recent Advances in the Development of PD-L1 Modulators: Degraders, Downregulators, and Covalent Inhibitors.
Southern Medical University
Design, synthesis and biological evaluation of novel potent STAT3 inhibitors based on BBI608 for cancer therapy.
Shanghai University of Traditional Chinese Medicine
NO-releasing STAT3 inhibitors suppress BRAF-mutant melanoma growth.
The University of Texas At Austin
Screening and biological evaluation of a novel STAT3 signaling pathway inhibitor against cancer.
Dalian Medical University
SD-91 as A Potent and Selective STAT3 Degrader Capable of Achieving Complete and Long-Lasting Tumor Regression.
University of Michigan
Structure-Activity Study of Nitazoxanide Derivatives as Novel STAT3 Pathway Inhibitors.
Peking University Health Science Center
Discovery of a Napabucasin PROTAC as an Effective Degrader of the E3 Ligase ZFP91.
University of Michigan
Discovery of Novel Azetidine Amides as Potent Small-Molecule STAT3 Inhibitors.
University of Hawaii Cancer Center
A panoramic review of IL-6: Structure, pathophysiological roles and inhibitors.
Punjabi University
STAT3 inhibitory activity of naphthoquinones isolated from Tabebuia avellanedae.
Kindai University
Allosteric Modulator Discovery: From Serendipity to Structure-Based Design.
Shanghai Jiao-Tong University School of Medicine
Design, synthesis and activity of novel 2,6-disubstituted purine derivatives, potential small molecule inhibitors of signal transducer and activator of transcription 3.
Wenzhou Medical University
A novel series of napabucasin derivatives as orally active inhibitors of signal transducer and activator of transcription 3 (STAT3).
Sichuan University
Bifunctional Naphthoquinone Aromatic Amide-Oxime Derivatives Exert Combined Immunotherapeutic and Antitumor Effects through Simultaneous Targeting of Indoleamine-2,3-dioxygenase and Signal Transducer and Activator of Transcription 3.
Guangxi Normal University
Structure-Based Discovery of SD-36 as a Potent, Selective, and Efficacious PROTAC Degrader of STAT3 Protein.
TBA
Towards lead compounds as anti-cancer agents via new phaeosphaeride A derivatives.
Federal Medical Biological Agency
Small-molecule compounds targeting the STAT3 DNA-binding domain suppress survival of cisplatin-resistant human ovarian cancer cells by inducing apoptosis.
Peking Union Medical College
Linker Variation and Structure-Activity Relationship Analyses of Carboxylic Acid-based Small Molecule STAT3 Inhibitors.
University of Hawaii Cancer Center
Piperlongumine derivative, CG-06, inhibits STAT3 activity by direct binding to STAT3 and regulating the reactive oxygen species in DU145 prostate carcinoma cells.
Chungnam National University
Electrophilic Triterpenoid Enones: A Comparative Thiol-Trapping and Bioactivity Study.
University of Eastern Piedmont
Andrographolide derivative as STAT3 inhibitor that protects acute liver damage in mice.
University of Macau
Napabucasin and Related Heterocycle-Fused Naphthoquinones as STAT3 Inhibitors with Antiproliferative Activity against Cancer Cells.
Westphalian Wilhelms University
Cornusides A-O, Bioactive Iridoid Glucoside Dimers from the Fruit of Cornus officinalis.
Beijing University of Chinese Medicine
A small-molecule screen identifies the antitrypanosomal agent suramin and analogues NF023 and NF449 as inhibitors of STAT5a/b.
Leipzig University
Pyrazolo[3,4-b]pyridine compounds as inhibitors of TAM and MET kinases
Array Biopharma
Compounds for cancer chemotherapeutic sensitization
Regents of The University of Minnesota
Substituted benzothienyl-pyrrolotriazines and uses thereof in the treatment cancer
Bayer Intellectual Property
Substituted 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-C]pyridines, their use as medicament, and pharmaceutical preparations comprising them
Sanofi
Proteome-wide Profiling of Clinical PARP Inhibitors Reveals Compound-Specific Secondary Targets.
H. Lee Moffitt Cancer Center & Research Institute
Active site ring-opening of a thiirane moiety and picomolar inhibition of gelatinases.
University of Notre Dame