Compile Data Set for Download or QSAR
Report error Found 29 Enz. Inhib. hit(s) with all data for entry = 50018446
TargetSignal transducer and activator of transcription 3(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50605550(C-188-9 | Stat3 inhibitor c188-9 | Stat3 inhibitor...)
Affinity DataKd:  4.70nMAssay Description:Binding affinity to STAT3 (127 to 722 residues) (unknown origin) by microscale thermophoresis analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50353432(CHEMBL1829876 | US10196373, Compound 45O)
Affinity DataKd:  504nMAssay Description:Binding affinity to STAT3 (unknown origin) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50608325(CHEMBL3823609)
Affinity DataIC50: 250nMAssay Description:Inhibition of STAT3 in human HepG2 cells assessed as inhibition of IL-6 induced STAT3 phosphorylation incubated for 60 mins by western blot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM11242(5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...)
Affinity DataIC50: 1.93E+3nMAssay Description:Inhibition of human recombinant STAT3 assessed as reduction in DNA binding activity with HepG2 nuclear extract incubated for 1 hr by ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50605550(C-188-9 | Stat3 inhibitor c188-9 | Stat3 inhibitor...)
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibition of STAT3 in human KG-1 cells assessed as inhibition of G-CSF induced STAT3 phosphorylation incubated for 60 mins by western blot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50396169(CHEMBL1337170)
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of STAT3 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50353432(CHEMBL1829876 | US10196373, Compound 45O)
Affinity DataIC50: 6.80E+3nMAssay Description:Inhibition of recombinant STAT3 (unknown origin) expressed in baculovirus in Sf9 insect cells assessed as reduction in DNA binding activity with NIH3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50605550(C-188-9 | Stat3 inhibitor c188-9 | Stat3 inhibitor...)
Affinity DataIC50: 8.30E+3nMAssay Description:Inhibition of STAT3 in human NB-4 cells assessed as inhibition of G-CSF induced STAT3 phosphorylation incubated for 60 mins by western blot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50608327(CHEMBL5276499)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant STAT3 (unknown origin) expressed in Escherichia coli BL21 (DE3) cells assessed as reduction in DNA binding activity with SK...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50396169(CHEMBL1337170)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of STAT3 (unknown origin) expressed in mouse NIH3T3 cells assessed as reduction in DNA binding activity incubated for 20 mins in presence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50608326(CHEMBL5275055)
Affinity DataIC50: 1.38E+4nMAssay Description:Inhibition of STAT3 (unknown origin) stably expressed in human MDA-MB-231 cells incubated for 48 hrs by Luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50608326(CHEMBL5275055)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of FLAG-tagged STAT3 (unknown origin) expressed in human NCI-H1299 cells assessed as reduction in DNA binding activity incubated for 20 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50396170(CHEMBL2031566)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant STAT3 (unknown origin) incubated for 30 mins by high-throughput fluorescence microscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50608326(CHEMBL5275055)
Affinity DataIC50: 2.13E+4nMAssay Description:Inhibition of recombinant YFP tagged STAT3 (127 to 688 residues) (unknown origin) incubated for 24 hrs by EMSA analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50396183(CHEMBL2172015)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of recombinant STAT3 (unknown origin) expressed in baculovirus in Sf9 insect cells assessed as reduction in DNA binding activity with NIH3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50353441(CHEMBL1829786)
Affinity DataIC50: 3.50E+4nMAssay Description:Inhibition of recombinant STAT3 (unknown origin) expressed in baculovirus in Sf9 insect cells assessed as reduction in DNA binding activity with NIH3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50396170(CHEMBL2031566)
Affinity DataIC50: 3.90E+4nMAssay Description:Inhibition of STAT3 in human HepG2 cells assessed as inhibition of IL-6 induced STAT3 translocation incubated for 60 mins by confocal fluorescence mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM20273((2S)-2-[(2S)-2-[(4-cyanophenyl)formamido]-3-[4-(ph...)
Affinity DataIC50: 4.20E+4nMAssay Description:Inhibition of STAT3 (unknown origin) DNA binding activity by electrophoretic mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM20282(4-{[4-(hexylcarbamoyl)-2-(naphthalen-1-yl)-1,3-oxa...)
Affinity DataIC50: 5.80E+4nMAssay Description:Inhibition of recombinant STAT3 (unknown origin) expressed in baculovirus in Sf9 insect cells assessed as reduction in DNA binding activity with NIH3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50396170(CHEMBL2031566)
Affinity DataIC50: 7.30E+4nMAssay Description:Inhibition of STAT3 in human HepG2 cells assessed as inhibition of IL-6 induced STAT3 phosphorylation incubated for 60 mins by western blot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50608322(CHEMBL5279594)
Affinity DataIC50: 1.15E+5nMAssay Description:Inhibition of recombinant STAT3 (unknown origin) expressed in baculovirus in Sf9 insect cells assessed as reduction in DNA binding activity with NIH3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50608319(CHEMBL5276064)
Affinity DataIC50: 1.82E+5nMAssay Description:Inhibition of recombinant STAT3 (unknown origin) expressed in baculovirus in Sf9 insect cells assessed as reduction in DNA binding activity with NIH3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50608323(CHEMBL5266557)
Affinity DataIC50: 1.94E+5nMAssay Description:Inhibition of recombinant STAT3 (unknown origin) expressed in baculovirus in Sf9 insect cells assessed as reduction in DNA binding activity with NIH3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50608320(CHEMBL5280162)
Affinity DataIC50: 2.17E+5nMAssay Description:Inhibition of recombinant STAT3 (unknown origin) expressed in baculovirus in Sf9 insect cells assessed as reduction in DNA binding activity with NIH3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50608324(CHEMBL5277946)
Affinity DataIC50: 2.35E+5nMAssay Description:Inhibition of recombinant STAT3 (unknown origin) expressed in baculovirus in Sf9 insect cells assessed as reduction in DNA binding activity with NIH3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM144582(US8969578, 17)
Affinity DataIC50: 2.55E+5nMAssay Description:Inhibition of recombinant STAT3 (unknown origin) expressed in baculovirus in Sf9 insect cells assessed as reduction in DNA binding activity with NIH3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50608321(CHEMBL5267613)
Affinity DataIC50: 2.92E+5nMAssay Description:Inhibition of recombinant STAT3 (unknown origin) expressed in baculovirus in Sf9 insect cells assessed as reduction in DNA binding activity with NIH3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50440965(CHEMBL2431982)
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of recombinant STAT3 (unknown origin) expressed in baculovirus in Sf9 insect cells assessed as reduction in DNA binding activity with NIH3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50440966(CHEMBL2431981)
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of recombinant STAT3 (unknown origin) expressed in baculovirus in Sf9 insect cells assessed as reduction in DNA binding activity with NIH3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed