Compile Data Set for Download or QSAR
Report error Found 81 Enz. Inhib. hit(s) with all data for entry = 50020220
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM424361(US10508120, Compound I-816 | US10508120, Compound ...)
Affinity DataKd:  0.00300nMAssay Description:Binding affinity to TYK2 JH2 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50507816(Bms-986165 | Deucravacitinib | US12351572, Example...)
Affinity DataKd:  0.00800nMAssay Description:Binding affinity to TYK2 JH2 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50627870(CHEMBL5424497)
Affinity DataKd:  0.0190nMAssay Description:Binding affinity to human recombinant TYK2 (556 to 871 residues) incubated for 10 hrs by microplate reader based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50507816(Bms-986165 | Deucravacitinib | US12351572, Example...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human recombinant C-terminal Histidine tagged TYK2 JH2 (564 to 876 residues) expressed in Sf9 cells by chromatography methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50507816(Bms-986165 | Deucravacitinib | US12351572, Example...)
Affinity DataKd:  0.230nMAssay Description:Binding affinity to JAK1 JH2 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50519537(CHEMBL4469750)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human recombinant C-terminal Histidine tagged TYK2 JH2 (564 to 876 residues) expressed in Sf9 cells by chromatography methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50530394(CHEMBL4561663)
Affinity DataIC50: 0.460nMAssay Description:Inhibition of human recombinant C-terminal Histidine tagged TYK2 JH2 (564 to 876 residues) expressed in Sf9 cells by chromatography methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50627870(CHEMBL5424497)
Affinity DataKd:  0.520nMAssay Description:Binding affinity to JAK1 JH2 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50530398(CHEMBL4526283)
Affinity DataIC50: 0.920nMAssay Description:Inhibition of human recombinant C-terminal Histidine tagged TYK2 JH2 (564 to 876 residues) expressed in Sf9 cells by chromatography methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50530395(CHEMBL4444178)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human recombinant C-terminal Histidine tagged TYK2 JH2 (564 to 876 residues) expressed in Sf9 cells by chromatography methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50507816(Bms-986165 | Deucravacitinib | US12351572, Example...)
Affinity DataIC50: 3nMAssay Description:Inhibition of JAK3 signaling pathway in human PBMC cells assessed as reduction of IL-2 induced STAT5 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50507816(Bms-986165 | Deucravacitinib | US12351572, Example...)
Affinity DataIC50: 5nMAssay Description:Inhibition of JAK1 signaling pathway in human PBMC cells assessed as reduction of IL-2 induced STAT5 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50507816(Bms-986165 | Deucravacitinib | US12351572, Example...)
Affinity DataKd:  10nMAssay Description:Binding affinity to JAK2 JH2 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50519537(CHEMBL4469750)
Affinity DataIC50: 13nMAssay Description:Inhibition of IL-23 induced STAT3 phosphorylation in human KIT225 cells by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50530395(CHEMBL4444178)
Affinity DataIC50: 15nMAssay Description:Inhibition of IL-23 induced STAT3 phosphorylation in human KIT225 cells by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50530394(CHEMBL4561663)
Affinity DataIC50: 15nMAssay Description:Inhibition of TYK2 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50243388(AT-9283 | US10981896, Compound AT9283)
Affinity DataIC50: 20nMAssay Description:Inhibition of human recombinant C-terminal Histidine tagged TYK2 JH1 (886 to 1187 residues) expressed in Sf9 cells by chromatography methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50530394(CHEMBL4561663)
Affinity DataIC50: 24nMAssay Description:Inhibition of JAK2 JH1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50530394(CHEMBL4561663)
Affinity DataIC50: 26nMAssay Description:Inhibition of JAK1 JH1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50623925(CHEMBL5426374)
Affinity DataIC50: 32nMAssay Description:Inhibition of TYK2 signalling pathway in human PBMC cells assessed as IFN alpha induced p-STAT1 levelMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50530394(CHEMBL4561663)
Affinity DataIC50: 37nMAssay Description:Inhibition of TYK2 JH2 in human KIT225 cells assessed as reduction of IFNalpha induced STAT1 phosphorylation by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50243388(AT-9283 | US10981896, Compound AT9283)
Affinity DataIC50: 40nMAssay Description:Inhibition of human recombinant C-terminal Histidine tagged TYK2 JH2 (564 to 876 residues) expressed in Sf9 cells by chromatography methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50623925(CHEMBL5426374)
Affinity DataIC50: 46nMAssay Description:Inhibition of TYK2 signalling pathway in human PBMC cells assessed as IFN alpha induced p-STAT3 levelMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50243388(AT-9283 | US10981896, Compound AT9283)
Affinity DataIC50: 50nMAssay Description:Inhibition of human JAK2 JH1 (836 to 1132 residues)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK1(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50243388(AT-9283 | US10981896, Compound AT9283)
Affinity DataIC50: 60nMAssay Description:Inhibition of human JAK1 JH1 (866 to 1154 residues)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50170831(N*6*-Cyclohexyl-N*2*-(4-morpholin-4-yl-phenyl)-9H-...)
Affinity DataIC50: 60nMAssay Description:Inhibition of human recombinant TYK2 JH2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50170831(N*6*-Cyclohexyl-N*2*-(4-morpholin-4-yl-phenyl)-9H-...)
Affinity DataIC50: 60nMAssay Description:Inhibition of human recombinant C-terminal Histidine tagged TYK2 JH2 (564 to 876 residues) expressed in Sf9 cells by chromatography methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50530398(CHEMBL4526283)
Affinity DataIC50: 63nMAssay Description:Inhibition of TYK2 JH2 in human KIT225 cells assessed as reduction of IFNalpha induced STAT1 phosphorylation by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSignal transducer and activator of transcription 3(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50530394(CHEMBL4561663)
Affinity DataIC50: 89nMAssay Description:Inhibition of IL-23 induced STAT3 phosphorylation in human Jurkat cells incubated for 30 mins by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50507816(Bms-986165 | Deucravacitinib | US12351572, Example...)
Affinity DataIC50: 89nMAssay Description:Inhibition of IL-23 induced STAT3 phosphorylation in human KIT225 cells by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50596971(CHEMBL5207367)
Affinity DataKd:  96nMAssay Description:Binding affinity to wild type JAK2 JH2 (unknown origin) assessed as dissociation constant by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50596971(CHEMBL5207367)
Affinity DataKd:  106nMAssay Description:Binding affinity to JAK2 JH2 V617F mutant (unknown origin) assessed as dissociation constant by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50170831(N*6*-Cyclohexyl-N*2*-(4-morpholin-4-yl-phenyl)-9H-...)
Affinity DataIC50: 120nMAssay Description:Inhibition of human recombinant TYK2 JH1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50170831(N*6*-Cyclohexyl-N*2*-(4-morpholin-4-yl-phenyl)-9H-...)
Affinity DataIC50: 120nMAssay Description:Inhibition of human recombinant C-terminal Histidine tagged TYK2 JH1 (886 to 1187 residues) expressed in Sf9 cells by chromatography methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50530394(CHEMBL4561663)
Affinity DataIC50: 180nMAssay Description:Inhibition of IL-23 induced STAT3 phosphorylation in human KIT225 cells by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50627870(CHEMBL5424497)
Affinity DataKd:  190nMAssay Description:Binding affinity to wild type JAK2 JH2 (unknown origin) assessed as dissociation constant by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50530398(CHEMBL4526283)
Affinity DataIC50: 230nMAssay Description:Inhibition of IL-23 induced STAT3 phosphorylation in human KIT225 cells by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50627873(CHEMBL4287367)
Affinity DataKd:  250nMAssay Description:Binding affinity to N-terminal His6-tagged human TYK2 (556 to 871 residues) expressed in baculovirus assessed as dissociation constant incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50627870(CHEMBL5424497)
Affinity DataKd:  300nMAssay Description:Binding affinity to TYK2 JH1 domain (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50170831(N*6*-Cyclohexyl-N*2*-(4-morpholin-4-yl-phenyl)-9H-...)
Affinity DataIC50: 300nMAssay Description:Inhibition of JAK3 JH1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50170831(N*6*-Cyclohexyl-N*2*-(4-morpholin-4-yl-phenyl)-9H-...)
Affinity DataIC50: 350nMAssay Description:Inhibition of JAK1 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50170831(N*6*-Cyclohexyl-N*2*-(4-morpholin-4-yl-phenyl)-9H-...)
Affinity DataIC50: 350nMAssay Description:Inhibition of human JAK1 JH1 (866 to 1154 residues)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM6866(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b ...)
Affinity DataKd:  460nMAssay Description:Binding affinity to wild type full length JAK2 JH2 (unknown origin) expressed in HEK293 cells assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50627874(CHEMBL4289149)
Affinity DataIC50: 480nMAssay Description:Inhibition of N-terminal His-tagged human TYK2 JH2 domain incubated for 30 mins by scintillation methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM6866(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b ...)
Affinity DataKd:  600nMAssay Description:Binding affinity to JAK2 V617F mutant (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM6866(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b ...)
Affinity DataKd:  670nMAssay Description:Binding affinity to JAK2 JH1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50170831(N*6*-Cyclohexyl-N*2*-(4-morpholin-4-yl-phenyl)-9H-...)
Affinity DataIC50: 680nMAssay Description:Inhibition of JAK2 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50170831(N*6*-Cyclohexyl-N*2*-(4-morpholin-4-yl-phenyl)-9H-...)
Affinity DataIC50: 680nMAssay Description:Inhibition of human JAK2 JH1 (836 to 1132 residues)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50170831(N*6*-Cyclohexyl-N*2*-(4-morpholin-4-yl-phenyl)-9H-...)
Affinity DataIC50: 1.30E+3nMAssay Description:Binding affinity to wild type JAK2 JH2 (unknown origin) assessed as dissociation constant by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50170831(N*6*-Cyclohexyl-N*2*-(4-morpholin-4-yl-phenyl)-9H-...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of human JAK2 JH2 (503 to 827 residues)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
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