Compile Data Set for Download or QSAR
Report error Found 9 Enz. Inhib. hit(s) with all data for entry = 7680
TargetPoly [ADP-ribose] polymerase 1(Human)
H. Lee Moffitt Cancer Center & Research Institute

LigandPNGBDBM50446130(AG-014699 | AG-14447 | Rucaparib | RUCAPARIB CAMSY...)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of PARP1 was assessed using the Universal Chemiluminescent PARPKit. Luminescence readings were normalized to controls and fit to a sigmoid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 1(Human)
H. Lee Moffitt Cancer Center & Research Institute

LigandPNGBDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of PARP1 was assessed using the Universal Chemiluminescent PARPKit. Luminescence readings were normalized to controls and fit to a sigmoid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 1(Human)
H. Lee Moffitt Cancer Center & Research Institute

LigandPNGBDBM209931(c-Rucaparib)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of PARP1 was assessed using the Universal Chemiluminescent PARPKit. Luminescence readings were normalized to controls and fit to a sigmoid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2017
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
H. Lee Moffitt Cancer Center & Research Institute

LigandPNGBDBM209930(c-Olaparib)
Affinity DataIC50: 5.90nMAssay Description:Inhibition of PARP1 was assessed using the Universal Chemiluminescent PARPKit. Luminescence readings were normalized to controls and fit to a sigmoid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2017
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
H. Lee Moffitt Cancer Center & Research Institute

LigandPNGBDBM209933(c-Veliparib)
Affinity DataIC50: 8.40nMAssay Description:Inhibition of PARP1 was assessed using the Universal Chemiluminescent PARPKit. Luminescence readings were normalized to controls and fit to a sigmoid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2017
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
H. Lee Moffitt Cancer Center & Research Institute

LigandPNGBDBM209932(Veliparib | 2-[(2R)-2-methylpyrrolidin-2-yl]-1H-be...)
Affinity DataIC50: 10.3nMAssay Description:Inhibition of PARP1 was assessed using the Universal Chemiluminescent PARPKit. Luminescence readings were normalized to controls and fit to a sigmoid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2017
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
H. Lee Moffitt Cancer Center & Research Institute

LigandPNGBDBM50316226(MK-4827 | (S)-2-(4-(piperidin-3-yl)phenyl)-2H-inda...)
Affinity DataIC50: 11.7nMAssay Description:Inhibition of PARP1 was assessed using the Universal Chemiluminescent PARPKit. Luminescence readings were normalized to controls and fit to a sigmoid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2017
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
H. Lee Moffitt Cancer Center & Research Institute

LigandPNGBDBM209929(c-Niraparib)
Affinity DataIC50: 48.4nMAssay Description:Inhibition of PARP1 was assessed using the Universal Chemiluminescent PARPKit. Luminescence readings were normalized to controls and fit to a sigmoid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2017
Entry Details Article
PubMed
TargetGDH/6PGL endoplasmic bifunctional protein(Human)
H. Lee Moffitt Cancer Center & Research Institute

LigandPNGBDBM50446130(AG-014699 | AG-14447 | Rucaparib | RUCAPARIB CAMSY...)
Affinity DataIC50: 1.80E+4nMAssay Description:HEK293 H6PD-OE and HEK293 pellets were lysed and the lysate was quantified with the Bradford protein assay. Reaction mix containing galactose-6-phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2017
Entry Details Article
PubMed