80 articles for thisTarget
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The synthesis and biological evaluation of alkyl and benzyl naphthyridinium analogs of eupolauridine as potential antimicrobial and cytotoxic agents.
Southern Research Institute
Structure-based hybridization, synthesis and biological evaluation of novel tetracyclic heterocyclic azathioxanthone analogues as potential antitumor agents.
Taipei Medical University
Design, synthesis and evaluation of thiohydantoin derivatives as potent topoisomerase I (Top1) inhibitors with anticancer activity.
Shiv Nadar University
Stereoselective synthesis of 11-phenylundeca-5Z,9Z-dienoic acid and investigation of its human topoisomerase I and IIa inhibitory activity.
Russian Academy of Science
Inhibitory activities against topoisomerase I and II by isoaurostatin derivatives and their structure-activity relationships.
Kumamoto University
Inhibition of human topoisomerases I and II by simocyclinone D8.
University of Minnesota Medical School
Inverse virtual screening of antitumor targets: pilot study on a small database of natural bioactive compounds.
Universita Di Salerno
Synthesis and antiproliferative evaluation of certain indeno[1,2-c]quinoline derivatives. Part 2.
Kaohsiung Medical University
Cytotoxicity and inhibition of DNA topoisomerase I of polyhydroxylated triterpenoids and triterpenoid glycosides.
Stephen F. Austin State University
Indole alkaloids and other constituents of Rauwolfia serpentina.
Kobe Pharmaceutical University
Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex.
Decode Biostructures
Quantized surface complementarity diversity (QSCD): a model based on small molecule-target complementarity.
Neogenesis
Camptothecin and minor-groove binder hybrid molecules: synthesis, inhibition of topoisomerase I, and anticancer cytotoxicity in vitro.
University of Alberta
Antiretroviral agents as inhibitors of both human immunodeficiency virus type 1 integrase and protease.
National Cancer Institute-Bethesda
Synthesis, topoisomerase I inhibitory activity, and in vivo evaluation of 11-azacamptothecin analogs.
Glaxo Inc. Research Institute
Plant antitumor agents. 30. Synthesis and structure activity of novel camptothecin analogs.
Research Triangle Institute
Syntheses of novel antitumor dihydroxanthone derivatives with inhibitory activity against DNA topoisomerase II.
Ajinomoto
Catalytic inhibition of eukaryotic topoisomerases I and II by flavonol glycosides extracted from Vicia faba and Lotus edulis.
University of Thessaly
Ungeremine effectively targets mammalian as well as bacterial type I and type II topoisomerases.
University of Cagliari
A Strategy for Identifying Novel, Mechanistically Unique Inhibitors of Topoisomerase I
TBA
The synthesis and evaluation of flexible analogues of the topoisomerase I inhibitor, camptothecin
TBA
Synthesis and biological activities of topoisomerase I inhibitors, 6-arylmethylamino analogues of edotecarin.
Tsukuba Research Institute
Synthesis of new camptothecin analogs with improved antitumor activities.
Chugai Pharmaceutical
Total synthesis and biological evaluation of (5Z,9Z)-5,9-hexadecadienoic acid, an inhibitor of human topoisomerase I.
University of Puerto Rico
Bioactive abietane and seco-abietane diterpenoids from Salvia prionitis.
Chinese Academy of Sciences
Isoaurostatin, a novel topoisomerase inhibitor produced by Thermomonospora alba.
Kumamoto University
ATP-competitive inhibitors of human DNA topoisomerase IIα with improved antiproliferative activity based on N-phenylpyrrolamide scaffold.
University of Ljubljana
Synthesis, cytotoxicity, and DNA topoisomerase II inhibitory activity of benzofuroquinolinediones.
Ewha Womans University
Sulfonamide derivatives as potential anti-cancer agents and their SARs elucidation.
Hunan University of Science and Technology
A comprehensive overview of β-carbolines and its derivatives as anticancer agents.
Xinyang Normal University
Quinoline anticancer agents active on DNA and DNA-interacting proteins: From classical to emerging therapeutic targets.
University of Palermo
A review: Biologically active 3,4-heterocycle-fused coumarins.
Tehran University of Medical Sciences
Molecular hybrids: A five-year survey on structures of multiple targeted hybrids of protein kinase inhibitors for cancer therapy.
Al-Azhar University
Fused-azepinones: Emerging scaffolds of medicinal importance.
National Institute of Pharmaceutical Education and Research (NIPER)
-2-(Phenylamino) Benzamide Derivatives as Dual Inhibitors of COX-2 and Topo I Deter Gastrointestinal Cancers via Targeting Inflammation and Tumor Progression.
Lanzhou University
Design, synthesis of DNA-interactive 4-thiazolidinone-based indolo-/pyrroloazepinone conjugates as potential cytotoxic and topoisomerase I inhibitors.
National Institute of Pharmaceutical Education and Research (NIPER)
Topoisomerase I inhibitors: Challenges, progress and the road ahead.
Csir-Indian Institute of Chemical Biology
Discovery of a fluoroindolo[2,3-a]carbazole clinical candidate with broad spectrum antitumor activity in preclinical tumor models superior to the marketed oncology drug, CPT-11.
The Bristol-Myers Squibb Pharmaceutical Research Institute
Paradigm shift of "classical" HDAC inhibitors to "hybrid" HDAC inhibitors in therapeutic interventions.
National Institute of Pharmaceutical Education and Research (NIPER)
Camptothecin analogs with bulky, hydrophobic substituents at the 7-position via a Grignard reaction.
Research Triangle Institute
N-2-(phenylamino) benzamide derivatives as novel anti-glioblastoma agents: Synthesis and biological evaluation.
Lanzhou University
Inhibitory activities against topoisomerase I and II by polyhydroxybenzoyl amide derivatives and their structure-activity relationship.
Kumamoto University
Synthesis, topoisomerase I inhibition and structure-activity relationship study of 2,4,6-trisubstituted pyridine derivatives.
Liaoning Normal University
Synthesis, biological evaluation, and correlation of cytotoxicity versus redox potential of 1,4-naphthoquinone derivatives.
National Research Institute of Chinese Medicine
Development of a metabolically stable topoisomerase I poison as anticancer agent.
Csir-Indian Institute of Chemical Biology
Design, synthesis and screening of benzimidazole containing compounds with methoxylated aryl radicals as cytotoxic molecules on (HCT-116) colon cancer cells.
Misr University For Science & Technology
Design, synthesis, biological evaluation, QSAR analysis and molecular modelling of new thiazol-benzimidazoles as EGFR inhibitors.
National Research Centre
Synthesis and biological evaluation of novel A-ring modified hexacyclic camptothecin analogues.
Life Science Research Center
Tyrosyl-DNA phosphodiesterase inhibitors: Progress and potential.
Russian Academy of Sciences
Synthesis and biological activities of NB-506 analogues modified at the glucose group.
Banyu Tsukuba Research Institute
Synthesis and biological activities of NB-506 analogues: Effects of the positions of two hydroxyl groups at the indole rings.
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories
Naphthazarin derivatives (II): formation of glutathione conjugate, inhibition of DNA topoisomerase-I and cytotoxicity.
Chungnam National University
Synthesis and biological activities of topoisomerase I inhibitors, 6-N-amino analogues of NB-506.
Banyu Tsukuba Research Institute
Antileishmanial activity of new hybrid tetrahydroquinoline and quinoline derivatives with phosphorus substituents.
Universidad De Le£N
Indolocarbazole poisons of human topoisomerase I: regioisomeric analogues of ED-110.
Medichem Research
Review of the molecular mechanisms of Ganoderma lucidum triterpenoids: Ganoderic acids A, C2, D, F, DM, X and Y.
Shaanxi University of Science & Technology
Probing structural requirements for human topoisomerase I inhibition by a novel N1-Biphenyl fluoroquinolone.
University of Iowa
Discovery and Mechanistic Study of Tailor-Made Quinoline Derivatives as Topoisomerase 1 Poison with Potent Anticancer Activity.
Csir-Indian Institute of Chemical Biology
Water soluble inhibitors of topoisomerase I: quaternary salt derivatives of camptothecin.
Glaxo Wellcome Research Institute
Selective Inhibition of Bacterial Topoisomerase I by alkynyl-bisbenzimidazoles.
Clemson University
Synthesis and antibacterial evaluation of anziaic acid and analogues as topoisomerase I inhibitors.
University of Hawai'I At Hilo
Synthesis and antitumor activity of novel water soluble derivatives of camptothecin as specific inhibitors of topoisomerase I.
Glaxo Research Institute
Inhibition of herpes simplex virus type 1 helicase-primase by (dichloroanilino)purines and -pyrimidines.
Stanford University Medical School
Rigid analogs of camptothecin as DNA topoisomerase I inhibitors.
Glaxo Research Institute
Acylshikonin analogues: synthesis and inhibition of DNA topoisomerase-I.
Chungnam National University
Bioactive compounds from Combretum erythrophyllum.
Virginia Polytechnic Institute and State University
seco-Cyclothialidines: new concise synthesis, inhibitory activity toward bacterial and human DNA topoisomerases, and antibacterial properties.
Bayer
Substituted 1,5-naphthyridine derivatives as novel antileishmanial agents. Synthesis and biological evaluation.
Universidad De Le£N
Neutral Porphyrin Derivative Exerts Anticancer Activity by Targeting Cellular Topoisomerase I (Top1) and Promotes Apoptotic Cell Death without Stabilizing Top1-DNA Cleavage Complexes.
Ahmedabad University
Selective Inhibition of Escherichia coli RNA and DNA Topoisomerase I by Hoechst 33258 Derived Mono- and Bisbenzimidazoles.
Clemson University
Kinetic characterization of a slow-binding inhibitor of Bla2: thiomaltol.
Baylor University