Compile Data Set for Download or QSAR
Report error Found 14 Enz. Inhib. hit(s) with all data for entry = 50006454
TargetDNA topoisomerase 1(Human)
Glaxo Wellcome Research Institute

Curated by ChEMBL
LigandPNGBDBM50049295(7-ethyl-7-hydroxy-14-(3-hydroxymethyl-1-pyridinium...)
Affinity DataIC50: 100nMAssay Description:Average concentration of compound to cause 50% inhibition of topoisomerase-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
Glaxo Wellcome Research Institute

Curated by ChEMBL
LigandPNGBDBM50049303(7-ethyl-7-hydroxy-14-pyrazin-1-ium-1-ylmethyl-(7S)...)
Affinity DataIC50: 140nMAssay Description:Average concentration of compound to cause 50% inhibition of topoisomerase-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
Glaxo Wellcome Research Institute

Curated by ChEMBL
LigandPNGBDBM50049304(7-ethyl-7-hydroxy-14-(1H-1-imidazolylmethyl)-(7S)-...)
Affinity DataIC50: 160nMAssay Description:Average concentration of compound to cause 50% inhibition of topoisomerase-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
Glaxo Wellcome Research Institute

Curated by ChEMBL
LigandPNGBDBM50049292(8-ethyl-8-hydroxy-15-pyrazin-1-ium-1-ylmethyl-(8S)...)
Affinity DataIC50: 180nMAssay Description:Average concentration of compound to cause 50% inhibition of topoisomerase-1 isolated from calf thymusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
Glaxo Wellcome Research Institute

Curated by ChEMBL
LigandPNGBDBM50049296(7-ethyl-7-hydroxy-14-pyridazin-1-ium-1-ylmethyl-(7...)
Affinity DataIC50: 190nMAssay Description:Average concentration of compound to cause 50% inhibition of topoisomerase-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
Glaxo Wellcome Research Institute

Curated by ChEMBL
LigandPNGBDBM50049294(8-ethyl-8-hydroxy-15-(1-pyridiniumylmethyl)-(8S)-2...)
Affinity DataIC50: 190nMAssay Description:Average concentration of compound to cause 50% inhibition of topoisomerase-1 isolated from calf thymusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
Glaxo Wellcome Research Institute

Curated by ChEMBL
LigandPNGBDBM50049298(7-ethyl-7-hydroxy-14-(1H-imidazol-3-ium-3-ylmethyl...)
Affinity DataIC50: 200nMAssay Description:Average concentration of compound to cause 50% inhibition of topoisomerase-1 isolated from calf thymusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
Glaxo Wellcome Research Institute

Curated by ChEMBL
LigandPNGBDBM50049297(7-ethyl-7-hydroxy-14-(1-pyridiniumylmethyl)-(7S)-7...)
Affinity DataIC50: 210nMAssay Description:Average concentration of compound to cause 50% inhibition of topoisomerase-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
Glaxo Wellcome Research Institute

Curated by ChEMBL
LigandPNGBDBM50049299(7-ethyl-7-hydroxy-14-(3-methyl-1H-imidazol-3-ium-1...)
Affinity DataIC50: 220nMAssay Description:Average concentration of compound to cause 50% inhibition of topoisomerase-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
Glaxo Wellcome Research Institute

Curated by ChEMBL
LigandPNGBDBM50049293(8-ethyl-8-hydroxy-15-pyridazin-1-ium-1-ylmethyl-(8...)
Affinity DataIC50: 250nMAssay Description:Average concentration of compound to cause 50% inhibition of topoisomerase-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
Glaxo Wellcome Research Institute

Curated by ChEMBL
LigandPNGBDBM50049302(8-ethyl-8-hydroxy-15-(4-hydroxymethyl-1-pyridinium...)
Affinity DataIC50: 340nMAssay Description:Average concentration of compound to cause 50% inhibition of topoisomerase-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
Glaxo Wellcome Research Institute

Curated by ChEMBL
LigandPNGBDBM50049300(8-ethyl-8-hydroxy-15-(3-methyl-1H-imidazol-3-ium-1...)
Affinity DataIC50: 520nMAssay Description:Average concentration of compound to cause 50% inhibition of topoisomerase-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
Glaxo Wellcome Research Institute

Curated by ChEMBL
LigandPNGBDBM50049301(8-ethyl-8-hydroxy-15-(3-hydroxymethyl-1-pyridinium...)
Affinity DataIC50: 600nMAssay Description:Average concentration of compound to cause 50% inhibition of topoisomerase-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
Glaxo Wellcome Research Institute

Curated by ChEMBL
LigandPNGBDBM50008935(CHEMBL84 | 10-Dimethylaminomethyl-4-ethyl-4,9-dihy...)
Affinity DataIC50: 1.10E+3nMAssay Description:Average concentration of compound to cause 50% inhibition of topoisomerase-1 isolated from calf thymusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed