Compile Data Set for Download or QSAR
Report error Found 68 Enz. Inhib. hit(s) with all data for entry = 50018286
TargetVascular endothelial growth factor receptor 2(Human)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 0.170nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK2(Human)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM50410843(CHEMBL5281221)
Affinity DataIC50: 0.510nMAssay Description:Inhibition of JAK2 (unknown origin) by 33P-ATP radiolabeled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM50410844(CHEMBL5289028)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of JAK2 (unknown origin) by 33P-ATP radiolabeled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM50410803(CHEMBL5280359)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM50573217(CHEMBL4876307)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of MNK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM50410844(CHEMBL5289028)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of FLT3 (unknown origin) by 33P-ATP radiolabeled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM50410843(CHEMBL5281221)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of FLT3 (unknown origin) by 33P-ATP radiolabeled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM50512074(CHEMBL4575813)
Affinity DataIC50: 2nMAssay Description:Inhibition of HDAC (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM50410836(CHEMBL5274303)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
LigandPNGBDBM50594749(CHEMBL5170300)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate incubated for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM50512074(CHEMBL4575813)
Affinity DataIC50: 4nMAssay Description:Inhibition of JAK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM50410803(CHEMBL5280359)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
LigandPNGBDBM50594749(CHEMBL5170300)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate incubated for 1 hr in presence of ATP by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM50410838(CHEMBL5272716)
Affinity DataIC50: 8nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM50410804(CHEMBL5287477)
Affinity DataIC50: 10nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM50410803(CHEMBL5280359)
Affinity DataIC50: 10nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
LigandPNGBDBM50594749(CHEMBL5170300)
Affinity DataIC50: 14nMAssay Description:Inhibition of PI3Kbeta (unknown origin) using PIP2 as substrate incubated for 1 hr in presence of ATP by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM50410836(CHEMBL5274303)
Affinity DataIC50: 20nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM50410840(CHEMBL5284623)
Affinity DataIC50: 21nMAssay Description:Inhibition of BCR-Abl (unknown origin) incubated for 1 hr by ADP-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM50573217(CHEMBL4876307)
Affinity DataIC50: 26nMAssay Description:Inhibition of MNK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetDNA topoisomerase 2-beta(Human)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM50410828(CHEMBL5266387)
Affinity DataIC50: 26nMAssay Description:Inhibition of human DNA topoisomerase 2-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM50410800(CHEMBL5206193)
Affinity DataIC50: 31nMAssay Description:Inhibition of GST-fused EGFR (unknown origin) in presence of ATP by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM50410844(CHEMBL5289028)
Affinity DataIC50: 34nMAssay Description:Inhibition of His-tagged BRD4 (unknown origin) using biotinylated histone H4 peptide (1 to 21 residues) containing KAc (K5/8/12/16Ac) by chemilumines...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM50410845(CHEMBL5273021)
Affinity DataIC50: 38nMAssay Description:Inhibition of HSP90 alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM50410828(CHEMBL5266387)
Affinity DataIC50: 39nMAssay Description:Inhibition of EGFR (unknown origin) by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM50410802(CHEMBL5272853)
Affinity DataIC50: 45nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM50410838(CHEMBL5272716)
Affinity DataIC50: 46nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
LigandPNGBDBM50410845(CHEMBL5273021)
Affinity DataIC50: 48nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM50594749(CHEMBL5170300)
Affinity DataIC50: 50nMAssay Description:Inhibition of full length human recombinant HDAC1 using AcLys-Tyr-Lys(e-acetyl)-AMC as substrate incubated for 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM50594749(CHEMBL5170300)
Affinity DataIC50: 62nMAssay Description:Inhibition of full-length recombinant human HDAC6 using Boc-Lys(e-acetyl)-AMC as substrate incubated for 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM50410798(CHEMBL5283543)
Affinity DataIC50: 75nMAssay Description:Inhibition of GST-fused EGFR (unknown origin) in presence of ATP by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM50594716(CHEMBL5191956)
Affinity DataIC50: 85nMAssay Description:Inhibition of HDAC in human HeLa cell nuclear extract using Boc-Lys (acetyl)-AMC as substrate preincubated for 5 mins followed by substrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM50410841(CHEMBL5266767)
Affinity DataIC50: 86nMAssay Description:Inhibition of full length human BRAF V600E mutant using His-tagged full length human MEK1 (K97R) as substrate incubated for 20 mins by [gamma-33P]ATP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM50410801(CHEMBL5276251)
Affinity DataIC50: 90nMAssay Description:Inhibition of EGFR (unknown origin) phosphorylation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM50594719(CHEMBL5186583)
Affinity DataIC50: 93nMAssay Description:Inhibition of GST-fused EGFR (unknown origin) in presence of ATP by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetTubulin beta-4B chain(Human)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM50410800(CHEMBL5206193)
Affinity DataIC50: 108nMAssay Description:Inhibition of beta-tubulin polymerization (unknown origin) by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM50410828(CHEMBL5266387)
Affinity DataIC50: 126nMAssay Description:Inhibition of VEGFR2 (unknown origin) by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM50410843(CHEMBL5281221)
Affinity DataIC50: 130nMAssay Description:Inhibition of His-tagged BRD4 (unknown origin) using biotinylated histone H4 peptide (1 to 21 residues) containing KAc (K5/8/12/16Ac) by chemilumines...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM50410840(CHEMBL5284623)
Affinity DataIC50: 150nMAssay Description:Inhibition of full length human recombinant HDAC1 using AcLys-Tyr-Lys(e-acetyl)-AMC as substrate incubated for 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM50410830(CHEMBL5286373)
Affinity DataIC50: 220nMAssay Description:Inhibition of EGFR (unknown origin) phosphorylation using kit-tyr4 peptide as substrate incubated for 1 hr in presence of ATP by UV-Vis spectrophotom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetDNA topoisomerase 1(Human)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM50008923(4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaz...)
Affinity DataIC50: 224nMAssay Description:Inhibition of human DNA topoisomerase 1 incubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetDNA topoisomerase 1(Human)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM50410829(CHEMBL5275527)
Affinity DataIC50: 278nMAssay Description:Inhibition of human DNA topoisomerase 1 incubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM50410836(CHEMBL5274303)
Affinity DataIC50: 306nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetApoptosis regulator Bcl-2(Human)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM50601447(CHEMBL5196783)
Affinity DataIC50: 460nMAssay Description:Inhibition of Bcl-2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM50410796(CHEMBL5290309)
Affinity DataIC50: 590nMAssay Description:Inhibition of human VEGFR2 using TMB as substrate by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM50410842(CHEMBL5273551)
Affinity DataIC50: 635nMAssay Description:Inhibition of recombinant HDAC1 (unknown origin) using Fluor-de-Lys as substrate incubated for 10 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM50410839(CHEMBL5289915)
Affinity DataIC50: 780nMAssay Description:Inhibition of HDAC in human HeLa cell nuclear extract using Boc-Lys (acetyl)-AMC as substrate preincubated for 15 mins followed by substrate addition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 2(Human)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM50601447(CHEMBL5196783)
Affinity DataIC50: 850nMAssay Description:Inhibition of CDK2 (unknown origin) using histone H1 as substrate [gamma-33P]-ATP based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM50410837(CHEMBL5270464)
Affinity DataIC50: 860nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM50410799(CHEMBL5284528)
Affinity DataIC50: 867nMAssay Description:Inhibition of GST-fused EGFR (unknown origin) in presence of ATP by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
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