Compile Data Set for Download or QSAR
Report error Found 63 Enz. Inhib. hit(s) with all data for entry = 50028691
TargetDNA topoisomerase 1(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249685(2,10-Dihydroxy-6-{[4-(hydroxymethyl)benzyl]amino}-...)
Affinity DataEC50:  34nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated DNA cleavage assessed as relaxation of supercoiled pBR322 plasmid DNA after 15 mins by densitometerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249687(2,10-Dihydroxy-6-{[3-(hydroxymethyl)benzyl]amino}-...)
Affinity DataEC50:  22nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated DNA cleavage assessed as relaxation of supercoiled pBR322 plasmid DNA after 15 mins by densitometerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249691(2,10-Dihydroxy-6-({[4-(hydroxymethyl)pyridin-2-yl]...)
Affinity DataEC50:  22nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated DNA cleavage assessed as relaxation of supercoiled pBR322 plasmid DNA after 15 mins by densitometerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249673(2,10-Dihydroxy-6-[(pyridin-3-ylmethyl)amino]-13-(b...)
Affinity DataEC50:  23nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated DNA cleavage assessed as relaxation of supercoiled pBR322 plasmid DNA after 15 mins by densitometerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249686(2,10-Dihydroxy-6-[(3-hydroxybenzyl)amino]-13-(beta...)
Affinity DataEC50:  23nMAssay Description:Inhibition of DNA topoisomerase 1 in mouse P388/S cells assessed as formation of topoisomerase 1-DNA complex by proteinase K/SDS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249688(2,10-Dihydroxy-6-{[2-(hydroxymethyl)benzyl]amino}-...)
Affinity DataEC50:  24nMAssay Description:Inhibition of DNA topoisomerase 1 in mouse P388/S cells assessed as formation of topoisomerase 1-DNA complex by proteinase K/SDS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249668(6-(Benzylamino)-2,10-dihydroxy-13-(beta-D-glucopyr...)
Affinity DataEC50:  25nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated DNA cleavage assessed as relaxation of supercoiled pBR322 plasmid DNA after 15 mins by densitometerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249693(2,10-Dihydroxy-6-({[4-(hydroxymethyl)pyridin-3-yl]...)
Affinity DataEC50:  25nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated DNA cleavage assessed as relaxation of supercoiled pBR322 plasmid DNA after 15 mins by densitometerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249690(2,10-Dihydroxy-6-({[5-(hydroxymethyl)pyridin-2-yl]...)
Affinity DataEC50:  27nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated DNA cleavage assessed as relaxation of supercoiled pBR322 plasmid DNA after 15 mins by densitometerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249696(2,10-Dihydroxy-6-({[3-(hydroxymethyl)pyridin-4-yl]...)
Affinity DataEC50:  29nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated DNA cleavage assessed as relaxation of supercoiled pBR322 plasmid DNA after 15 mins by densitometerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249670(6-[(3-Furylmethyl)amino]-2,10-dihydroxy-13-(beta-D...)
Affinity DataEC50:  30nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated DNA cleavage assessed as relaxation of supercoiled pBR322 plasmid DNA after 15 mins by densitometerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249671(2,10-Dihydroxy-6-[(1H-pyrrol-2-ylmethyl)amino]-13-...)
Affinity DataEC50:  30nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated DNA cleavage assessed as relaxation of supercoiled pBR322 plasmid DNA after 15 mins by densitometerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249672(2,10-Dihydroxy-6-[(pyridin-2-ylmethyl)amino]-13-(b...)
Affinity DataEC50:  30nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated DNA cleavage assessed as relaxation of supercoiled pBR322 plasmid DNA after 15 mins by densitometerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249677(2,10-Dihydroxy-6-[(quinolin-3-ylmethyl)amino]-13-(...)
Affinity DataEC50:  30nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated DNA cleavage assessed as relaxation of supercoiled pBR322 plasmid DNA after 15 mins by densitometerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249695(2,10-Dihydroxy-6-({[6-(hydroxymethyl)pyridin-3-yl]...)
Affinity DataEC50:  30nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated DNA cleavage assessed as relaxation of supercoiled pBR322 plasmid DNA after 15 mins by densitometerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249697(2,10-Dihydroxy-6-({[2-(hydroxymethyl)pyridin-4-yl]...)
Affinity DataEC50:  31nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated DNA cleavage assessed as relaxation of supercoiled pBR322 plasmid DNA after 15 mins by densitometerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249674(2,10-Dihydroxy-6-[(pyridin-4-ylmethyl)amino]-13-(b...)
Affinity DataEC50:  22nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated DNA cleavage assessed as relaxation of supercoiled pBR322 plasmid DNA after 15 mins by densitometerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249675(2,10-Dihydroxy-6-[(pyrazin-2-ylmethyl)amino]-13-(b...)
Affinity DataEC50:  35nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated DNA cleavage assessed as relaxation of supercoiled pBR322 plasmid DNA after 15 mins by densitometerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249694(2,10-Dihydroxy-6-({[5-(hydroxymethyl)pyridin-3-yl]...)
Affinity DataEC50:  35nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated DNA cleavage assessed as relaxation of supercoiled pBR322 plasmid DNA after 15 mins by densitometerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249669(6-[(2-Furylmethyl)amino]-2,10-dihydroxy-13-(beta-D...)
Affinity DataEC50:  38nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated DNA cleavage assessed as relaxation of supercoiled pBR322 plasmid DNA after 15 mins by densitometerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249689(2,10-Dihydroxy-6-({[6-(hydroxymethyl)pyridin-2-yl]...)
Affinity DataEC50:  73nMAssay Description:Inhibition of DNA topoisomerase 1 in mouse P388/S cells assessed as formation of topoisomerase 1-DNA complex by proteinase K/SDS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249668(6-(Benzylamino)-2,10-dihydroxy-13-(beta-D-glucopyr...)
Affinity DataEC50:  80nMAssay Description:Inhibition of DNA topoisomerase 1 in mouse P388/S cells assessed as formation of topoisomerase 1-DNA complex by proteinase K/SDS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249694(2,10-Dihydroxy-6-({[5-(hydroxymethyl)pyridin-3-yl]...)
Affinity DataEC50:  90nMAssay Description:Inhibition of DNA topoisomerase 1 in mouse P388/S cells assessed as formation of topoisomerase 1-DNA complex by proteinase K/SDS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249679(edotecarin | CHEMBL447069)
Affinity DataEC50:  100nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated DNA cleavage assessed as relaxation of supercoiled pBR322 plasmid DNA after 15 mins by densitometerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249679(edotecarin | CHEMBL447069)
Affinity DataEC50:  1.5nMAssay Description:Inhibition of DNA topoisomerase 1 in mouse P388/S cells assessed as formation of topoisomerase 1-DNA complex by proteinase K/SDS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249689(2,10-Dihydroxy-6-({[6-(hydroxymethyl)pyridin-2-yl]...)
Affinity DataEC50:  3.30nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated DNA cleavage assessed as relaxation of supercoiled pBR322 plasmid DNA after 15 mins by densitometerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249684(2,10-Dihydroxy-6-[(4-hydroxybenzyl)amino]-13-(beta...)
Affinity DataEC50:  12nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated DNA cleavage assessed as relaxation of supercoiled pBR322 plasmid DNA after 15 mins by densitometerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249688(2,10-Dihydroxy-6-{[2-(hydroxymethyl)benzyl]amino}-...)
Affinity DataEC50:  16nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated DNA cleavage assessed as relaxation of supercoiled pBR322 plasmid DNA after 15 mins by densitometerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249676(2,10-Dihydroxy-6-[(quinolin-2-ylmethyl)amino]-13-(...)
Affinity DataEC50:  17nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated DNA cleavage assessed as relaxation of supercoiled pBR322 plasmid DNA after 15 mins by densitometerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249692(2,10-Dihydroxy-6-({[3-(hydroxymethyl)pyridin-2-yl]...)
Affinity DataEC50:  19nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated DNA cleavage assessed as relaxation of supercoiled pBR322 plasmid DNA after 15 mins by densitometerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249678(2,10-Dihydroxy-6-[(quinolin-4-ylmethyl)amino]-13-(...)
Affinity DataEC50:  20nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated DNA cleavage assessed as relaxation of supercoiled pBR322 plasmid DNA after 15 mins by densitometerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249686(2,10-Dihydroxy-6-[(3-hydroxybenzyl)amino]-13-(beta...)
Affinity DataEC50:  20nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated DNA cleavage assessed as relaxation of supercoiled pBR322 plasmid DNA after 15 mins by densitometerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249676(2,10-Dihydroxy-6-[(quinolin-2-ylmethyl)amino]-13-(...)
Affinity DataEC50:  1.80E+3nMAssay Description:Inhibition of DNA topoisomerase 1 in mouse P388/S cells assessed as formation of topoisomerase 1-DNA complex by proteinase K/SDS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249690(2,10-Dihydroxy-6-({[5-(hydroxymethyl)pyridin-2-yl]...)
Affinity DataEC50:  120nMAssay Description:Inhibition of DNA topoisomerase 1 in mouse P388/S cells assessed as formation of topoisomerase 1-DNA complex by proteinase K/SDS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249695(2,10-Dihydroxy-6-({[6-(hydroxymethyl)pyridin-3-yl]...)
Affinity DataEC50:  130nMAssay Description:Inhibition of DNA topoisomerase 1 in mouse P388/S cells assessed as formation of topoisomerase 1-DNA complex by proteinase K/SDS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249696(2,10-Dihydroxy-6-({[3-(hydroxymethyl)pyridin-4-yl]...)
Affinity DataEC50:  130nMAssay Description:Inhibition of DNA topoisomerase 1 in mouse P388/S cells assessed as formation of topoisomerase 1-DNA complex by proteinase K/SDS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249691(2,10-Dihydroxy-6-({[4-(hydroxymethyl)pyridin-2-yl]...)
Affinity DataEC50:  160nMAssay Description:Inhibition of DNA topoisomerase 1 in mouse P388/S cells assessed as formation of topoisomerase 1-DNA complex by proteinase K/SDS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249669(6-[(2-Furylmethyl)amino]-2,10-dihydroxy-13-(beta-D...)
Affinity DataEC50:  180nMAssay Description:Inhibition of DNA topoisomerase 1 in mouse P388/S cells assessed as formation of topoisomerase 1-DNA complex by proteinase K/SDS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249675(2,10-Dihydroxy-6-[(pyrazin-2-ylmethyl)amino]-13-(b...)
Affinity DataEC50:  210nMAssay Description:Inhibition of DNA topoisomerase 1 in mouse P388/S cells assessed as formation of topoisomerase 1-DNA complex by proteinase K/SDS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249687(2,10-Dihydroxy-6-{[3-(hydroxymethyl)benzyl]amino}-...)
Affinity DataEC50:  220nMAssay Description:Inhibition of DNA topoisomerase 1 in mouse P388/S cells assessed as formation of topoisomerase 1-DNA complex by proteinase K/SDS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249683(2,10-Dihydroxy-6-[(4-cyanobenzyl)amino]-13-(beta-D...)
Affinity DataEC50:  300nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated DNA cleavage assessed as relaxation of supercoiled pBR322 plasmid DNA after 15 mins by densitometerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249692(2,10-Dihydroxy-6-({[3-(hydroxymethyl)pyridin-2-yl]...)
Affinity DataEC50:  400nMAssay Description:Inhibition of DNA topoisomerase 1 in mouse P388/S cells assessed as formation of topoisomerase 1-DNA complex by proteinase K/SDS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249674(2,10-Dihydroxy-6-[(pyridin-4-ylmethyl)amino]-13-(b...)
Affinity DataEC50:  420nMAssay Description:Inhibition of DNA topoisomerase 1 in mouse P388/S cells assessed as formation of topoisomerase 1-DNA complex by proteinase K/SDS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249670(6-[(3-Furylmethyl)amino]-2,10-dihydroxy-13-(beta-D...)
Affinity DataEC50:  470nMAssay Description:Inhibition of DNA topoisomerase 1 in mouse P388/S cells assessed as formation of topoisomerase 1-DNA complex by proteinase K/SDS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249685(2,10-Dihydroxy-6-{[4-(hydroxymethyl)benzyl]amino}-...)
Affinity DataEC50:  600nMAssay Description:Inhibition of DNA topoisomerase 1 in mouse P388/S cells assessed as formation of topoisomerase 1-DNA complex by proteinase K/SDS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249680(2,10-Dihydroxy-6-[(4-methylbenzyl)amino]-13-(beta-...)
Affinity DataEC50:  800nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated DNA cleavage assessed as relaxation of supercoiled pBR322 plasmid DNA after 15 mins by densitometerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249672(2,10-Dihydroxy-6-[(pyridin-2-ylmethyl)amino]-13-(b...)
Affinity DataEC50:  800nMAssay Description:Inhibition of DNA topoisomerase 1 in mouse P388/S cells assessed as formation of topoisomerase 1-DNA complex by proteinase K/SDS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249683(2,10-Dihydroxy-6-[(4-cyanobenzyl)amino]-13-(beta-D...)
Affinity DataEC50:  1.70E+3nMAssay Description:Inhibition of DNA topoisomerase 1 in mouse P388/S cells assessed as formation of topoisomerase 1-DNA complex by proteinase K/SDS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249684(2,10-Dihydroxy-6-[(4-hydroxybenzyl)amino]-13-(beta...)
Affinity DataEC50:  120nMAssay Description:Inhibition of DNA topoisomerase 1 in mouse P388/S cells assessed as formation of topoisomerase 1-DNA complex by proteinase K/SDS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249681(2,10-Dihydroxy-6-[(4-nitrolbenzyl)amino]-13-(beta-...)
Affinity DataEC50:  6.00E+3nMAssay Description:Inhibition of DNA topoisomerase 1 in mouse P388/S cells assessed as formation of topoisomerase 1-DNA complex by proteinase K/SDS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
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