84 articles for thisTarget
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New quinolinic derivatives as melatonergic ligands: Synthesis and pharmacological evaluation.
Universities of Lille
Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents.
Jagiellonian University Medical College
Tactical Approaches to Interconverting GPCR Agonists and Antagonists.
University of Minnesota
Melatonergic ligands: Design, synthesis and pharmacological evaluation of novel series of naphthofuranic derivatives.
University of Lille
Synthesis of 2-arylfuro[3,2-b]pyridines: Effect of the C2-aryl group on melatoninergic activity.
Orleans University
New coumarin-based fluorescent melatonin ligands. Design, synthesis and pharmacological characterization.
IQM-CSIC
Novel N-Acetyl Bioisosteres of Melatonin: Melatonergic Receptor Pharmacology, Physicochemical Studies, and Phenotypic Assessment of Their Neurogenic Potential.
IQM-CSIC
Efficient synthesis of hexahydroindenopyridines and their potential as melatoninergic ligands.
Universidad De Valencia
MT1 and MT2 melatonin receptors: ligands, models, oligomers, and therapeutic potential.
The German University In Cairo
Development of substituted N-[3-(3-methoxylphenyl)propyl] amides as MT(2)-selective melatonin agonists: improving metabolic stability.
Hong Kong University of Science and Technology
Synthesis of new N-(arylcyclopropyl)acetamides and N-(arylvinyl)acetamides as conformationally-restricted ligands for melatonin receptors.
Paris-Sud University
Bivalent ligand approach on N-{2-[(3-methoxyphenyl)methylamino]ethyl}acetamide: synthesis, binding affinity and intrinsic activity for MT(1) and MT(2) melatonin receptors.
University of Urbino
Design, synthesis, and pharmacological effects of structurally simple ligands for MT(1) and MT(2) melatonin receptors.
University of Bari Aldo Moro
Design, synthesis and pharmacological evaluation of novel naphthalenic derivatives as selective MT(1) melatoninergic ligands.
University of Lille
Mapping the melatonin receptor. 6. Melatonin agonists and antagonists derived from 6H-isoindolo[2,1-a]indoles, 5,6-dihydroindolo[2,1-a]isoquinolines, and 6,7-dihydro-5H-benzo[c]azepino[2,1-a]indoles.
King'S College London
Design and synthesis of 2-phenylimidazo[1,2-a]pyridines as a novel class of melatonin receptor ligands.
Orleans University
Synthesis of a novel series of tricyclic dihydrofuran derivatives: discovery of 8,9-dihydrofuro[3,2-c]pyrazolo[1,5-a]pyridines as melatonin receptor (MT1/MT2) ligands.
Takeda Pharmaceutical
Preparation and pharmacological evaluation of a novel series of 2-(phenylthio)benzo[b]thiophenes as selective MT2 receptor ligands.
University of Lille
1,6-Dihydro-2H-indeno[5,4-b]furan derivatives: design, synthesis, and pharmacological characterization of a novel class of highly potent MT2-selective agonists.
Takeda Pharmaceutical
Design and synthesis of naphthalenic derivatives as new ligands at the melatonin binding site MT3.
University of Lille
Design and synthesis of 1-(2-alkanamidoethyl)-6-methoxy-7-azaindole derivatives as potent melatonin agonists.
Orleans University
Discovery of potent, selective, and orally bioavailable 3H-spiro[isobenzofuran-1,4'-piperidine] based melanocortin subtype-4 receptor agonists.
Merck Research Laboratories
Synthesis of substituted N-[3-(3-methoxyphenyl)propyl] amides as highly potent MT(2)-selective melatonin ligands.
Hong Kong University of Science and Technology
Synthesis and pharmacological evaluation of 1,2,3,4-tetrahydropyrazino[1,2-a]indole and 2-[(phenylmethylamino)methyl]-1H-indole analogues as novel melatoninergic ligands.
University of W£Rzburg
Synthesis and receptor binding studies of quinolinic derivatives as melatonin receptor ligands
TBA
2-[(2,3-dihydro-1H-indol-1-yl)methyl]melatonin analogues: a novel class of MT2-selective melatonin receptor antagonists.
University of WüRzburg
Synthesis of 3-phenylnaphthalenic derivatives as new selective MT(2) melatoninergic ligands.
University of Lille 2
Synthesis and pharmacological evaluation of pentacyclic 6a,7-dihydrodiindole and 2,3-dihydrodiindole derivatives as novel melatoninergic ligands.
University of WüRzburg
Design and synthesis of benzofuranic derivatives as new ligands at the melatonin-binding site MT3.
Université
2-Arylmelatonin analogues: Probing the 2-phenyl binding pocket of melatonin MT
University of Urbino Carlo Bo
2-Phenylcyclopropylmethylamine (PCPMA) as a privileged scaffold for central nervous system drug design.
Shanghaitech University
Natural spirocyclic alkaloids and polyphenols as multi target dementia leads.
Rmit University
Recent research progress of Uncaria spp. based on alkaloids: phytochemistry, pharmacology and structural chemistry.
China Pharmaceutical University
Mapping the melatonin receptor. 7. Subtype selective ligands based on beta-substituted N-acyl-5-methoxytryptamines and beta-substituted N-acyl-5-methoxy-1-methyltryptamines.
University of Athens
Design and Validation of the First Family of Photo-Activatable Ligands for Melatonin Receptors.
University of Paris
Synthesis and biological evaluation of paeoveitol D derivatives as new melatonin receptor agonists with antidepressant activities.
Chinese Academy of Sciences
(R)-2-(4-Phenylbutyl)dihydrobenzofuran derivatives as melatoninergic agents.
Bristol-Myers Squibb Pharmaceutical Research Institute
Tetrahydroisoquinoline derivatives as melatonin MT2 receptor antagonists.
Bristol-Myers Squibb Pharmaceutical Research Institute
N-[2-[2-(4-Phenylbutyl)benzofuran-4-yl]cyclopropylmethyl]acetamide: an orally bioavailable melatonin receptor agonist.
Bristol-Myers Squibb Pharmaceutical Research Institute
Synthesis and structure-activity relationship of novel benzoxazole derivatives as melatonin receptor agonists.
Bristol-Myers Squibb Pharmaceutical Research Institute
4-Substituted anilides as selective melatonin MT2 receptor agonists.
Bristol-Myers Squibb Pharmaceutical Research Institute
Discovery of a Potent and Orally Bioavailable Melatonin Receptor Agonist.
Takeda Pharmaceutical
Design and synthesis of benzoxazole derivatives as novel melatoninergic ligands.
Bristol-Myers Squibb Pharmaceutical Research Institute
Heterocyclic aminopyrrolidine derivatives as melatoninergic agents.
Bristol-Myers Squibb Pharmaceutical Research Institute
Tuning melatonin receptor subtype selectivity in oxadiazolone-based analogues: Discovery of QR2 ligands and NRF2 activators with neurogenic properties.
IQM-CSIC
Design and synthesis of naphthalenic dimers as selective MT1 melatoninergic ligands.
Université
Indanyl piperazines as melatonergic MT2 selective agents.
Bristol-Myers Squibb Pharmaceutical Research Institute
Synthesis of a novel series of tricyclic indan derivatives as melatonin receptor agonists.
Takeda Chemical Industries
Synthesis and structure-affinity-activity relationships of novel benzofuran derivatives as MT(2) melatonin receptor selective ligands.
Institut De Chimie Pharmaceutique Albert Lespagnol
Synthesis of nitroindole derivatives with high affinity and selectivity for melatoninergic binding sites MT(3).
Institut De Chimie Pharmaceutique Albert Lespagnol
Quinazoline and phthalazine derivatives as novel melatonin receptor ligands analogues of agomelatine.
Umr-S1172 - Jparc - Centre De Recherche Jean-Pierre Aubert Neurosciences Et Cancer
Design and Discovery of Functionally Selective Serotonin 2C (5-HT
University of Illinois At Chicago
Synthesis of phenalene and acenaphthene derivatives as new conformationally restricted ligands for melatonin receptors.
Paris-Sud University
Design, Synthesis, and Characterization of Ogerin-Based Positive Allosteric Modulators for G Protein-Coupled Receptor 68 (GPR68).
Icahn School of Medicine At Mount Sinai
Polybenzyls from Gastrodia elata, their agonistic effects on melatonin receptors and structure-activity relationships.
Chinese Academy of Sciences
Synthesis of benzocycloalkane derivatives as new conformationally restricted ligands for melatonin receptors.
Paris-Sud University
Development of a high-affinity ligand that binds irreversibly to Mel1b melatonin receptors.
Duquesne University
Indole-based melatonin analogues: Synthetic approaches and biological activity.
Nantong University
Original Design of Fluorescent Ligands by Fusing BODIPY and Melatonin Neurohormone.
Orleans University
N-(substituted-anilinoethyl)amides: design, synthesis, and pharmacological characterization of a new class of melatonin receptor ligands.
University of Parma
7-Substituted-melatonin and 7-substituted-1-methylmelatonin analogues: effect of substituents on potency and binding affinity.
University College London
Analysis of structure-activity relationships for MT2 selective antagonists by melatonin MT1 and MT2 receptor models.
University of Parma
Tricyclic alkylamides as melatonin receptor ligands with antagonist or inverse agonist activity.
University of Milan
Three-dimensional quantitative structure-activity relationship studies on selected MT1 and MT2 melatonin receptor ligands: requirements for subtype selectivity and intrinsic activity modulation.
University of Parma
2-N-acylaminoalkylindoles: design and quantitative structure-activity relationship studies leading to MT2-selective melatonin antagonists.
University of Urbino
Generally applicable, convenient solid-phase synthesis and receptor affinities of octreotide analogs.
Washington University School of Medicine
Synthesis and biological evaluation of magnolol derivatives as melatonergic receptor agonists with potential use in depression.
Chinese Academy of Sciences
Synthesis and biological evaluation of new naphtho- and quinolinocyclopentane derivatives as potent melatoninergic (MT
Univ. Lille
Identification of Bivalent Ligands with Melatonin Receptor Agonist and Fatty Acid Amide Hydrolase (FAAH) Inhibitory Activity That Exhibit Ocular Hypotensive Effect in the Rabbit.
University of Urbino
Tetrahydroquinoline Ring as a Versatile Bioisostere of Tetralin for Melatonin Receptor Ligands.
University of Parma
Monoacylglycerol lipase modulators for use in autism spectrum disorders
Janssen Pharmaceutica
The influence of modifications in imide fragment structure on 5-HT(1A) and 5-HT(7) receptor affinity and in vivo pharmacological properties of some new 1-(m-trifluoromethylphenyl)piperazines.
Polish Academy of Sciences
Discovery of begacestat, a Notch-1-sparing gamma-secretase inhibitor for the treatment of Alzheimer's disease.
Wyeth Research
Pyrazolo[1,5-a]-1,3,5-triazine as a purine bioisostere: access to potent cyclin-dependent kinase inhibitor (R)-roscovitine analogue.
Universite De Lyon