37 articles for thisTarget
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Discovery and Preclinical Characterization of 3-((4-(4-Chlorophenyl)-7-fluoroquinoline-3-yl)sulfonyl)benzonitrile, a Novel Non-acetylenic Metabotropic Glutamate Receptor 5 (mGluR5) Negative Allosteric Modulator for Psychiatric Indications.
Gedeon Richter
The influence of 5-HT(2A) activity on a 5-HT(2C) specific in vivo assay used for early identification of multiple acting SERT and 5-HT(2C) receptor ligands.
Gedeon Richter
4-Aryl-3-arylsulfonyl-quinolines as negative allosteric modulators of metabotropic GluR5 receptors: From HTS hit to development candidate.
Gedeon Richter
Thieno[2,3-b]pyridines as negative allosteric modulators of metabotropic GluR5 receptors: Lead optimization.
Gedeon Richter
Thieno[2,3-b]pyridines as negative allosteric modulators of metabotropic GluR5 receptors: hit-to-lead optimization.
Gedeon Richter
Multiple fragment docking and linking in primary and secondary pockets of dopamine receptors.
Gedeon Richter
Design of novel multiple-acting ligands towards SERT and 5-HT2C receptors.
Gedeon Richter
Hit-to-lead optimization of disubstituted oxadiazoles and tetrazoles as mGluR5 NAMs.
Gedeon Richter
Discovery of cariprazine (RGH-188): a novel antipsychotic acting on dopamine D3/D2 receptors.
Gedeon Richter
Quinolinyl- and phenantridinyl-acetamides as bradykinin B1 receptor antagonists.
Gedeon Richter
Discovery of novel human histamine H4 receptor ligands by large-scale structure-based virtual screening.
Gedeon Richter
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods.
Gedeon Richter
Chemical and biological investigation of cyclopropyl containing diaryl-pyrazole-3-carboxamides as novel and potent cannabinoid type 1 receptor antagonists.
Gedeon Richter
Hit-to-lead optimization of pyrrolo[1,2-a]quinoxalines as novel cannabinoid type 1 receptor antagonists.
Gedeon Richter
Chemical and biological investigation of N-hydroxy-valdecoxib: An active metabolite of valdecoxib.
Gedeon Richter
Novel sulfonamides having dual dopamine D2 and D3 receptor affinity show in vivo antipsychotic efficacy with beneficial cognitive and EPS profile.
Gedeon Richter
Optimization of Novel α7 Nicotinic Acetylcholine Receptor Positive Allosteric Modulators and the Discovery of a Preclinical Development Candidate Molecule (RGH-560).
Gedeon Richter
Selective NR1/2B N-methyl-D-aspartate receptor antagonists among indole-2-carboxamides and benzimidazole-2-carboxamides.
Gedeon Richter
Novel imidazo[1,5-a]quinoxaline derivatives: SAR, selectivity and modeling challenges en route to the identification of an α5-GABAA receptor NAM.
Gedeon Richter
Benzimidazole-2-carboxamides as novel NR2B selective NMDA receptor antagonists.
Gedeon Richter
Multiparameter Optimization of Naphthyridine Derivatives as Selective α5-GABA
Gedeon Richter
Fragment-Based Optimization of Dihydropyrazino-Benzimidazolones as Metabotropic Glutamate Receptor-2 Positive Allosteric Modulators against Migraine.
Gedeon Richter
HTS-based discovery and optimization of novel positive allosteric modulators of the α7 nicotinic acetylcholine receptor.
Gedeon Richter
Discovery of novel positive allosteric modulators of the α7 nicotinic acetylcholine receptor: Scaffold hopping approach.
Gedeon Richter
New V1a receptor antagonist. Part 1. Synthesis and SAR development of urea derivatives.
Gedeon Richter
Discovery of dihydropyrazino-benzimidazole derivatives as metabotropic glutamate receptor-2 (mGluR2) positive allosteric modulators (PAMs).
Gedeon Richter
New V1a receptor antagonist. Part 2. Identification and optimization of triazolobenzazepines.
Gedeon Richter
Charting the chemical space around the (iso)indoline scaffold, a comprehensive approach towards multitarget directed ligands.
Gedeon Richter
New P2X3 receptor antagonists. Part 2: Identification and SAR of quinazolinones.
Gedeon Richter
New P2X3 receptor antagonists. Part 1: Discovery and optimization of tricyclic compounds.
Gedeon Richter
Fragment Based Optimization of Metabotropic Glutamate Receptor 2 (mGluR2) Positive Allosteric Modulators in the Absence of Structural Information.
Gedeon Richter