Compile Data Set for Download or QSAR
Report error Found 54 Enz. Inhib. hit(s) with all data for entry = 50014912
TargetMetabotropic glutamate receptor 2(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50581110(CHEMBL5074682)
Affinity DataEC50:  610nMAssay Description:Positive allosteric modulator activity at human mGlu2 receptor expressed in rat Chem-1 cells assessed as cytosolic Ca2+ ion concentration measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50581109(CHEMBL5076356)
Affinity DataEC50:  630nMAssay Description:Positive allosteric modulator activity at human mGlu2 receptor expressed in rat Chem-1 cells assessed as cytosolic Ca2+ ion concentration measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50581131(CHEMBL5079928)
Affinity DataEC50:  6.17E+3nMAssay Description:Positive allosteric modulator activity at human mGlu2 receptor expressed in rat Chem-1 cells assessed as cytosolic Ca2+ ion concentration measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50581130(CHEMBL5078979)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulator activity at human mGlu2 receptor expressed in rat Chem-1 cells assessed as cytosolic Ca2+ ion concentration measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50581129(CHEMBL5093066)
Affinity DataEC50:  79nMAssay Description:Positive allosteric modulator activity at human mGlu2 receptor expressed in rat Chem-1 cells assessed as cytosolic Ca2+ ion concentration measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50343328(cis-2-(((3S,4S)-4-(2-fluoro-4-(trifluoromethoxy)ph...)
Affinity DataEC50:  35nMAssay Description:Positive allosteric modulator activity at human mGlu2 receptor expressed in rat Chem-1 cells assessed as cytosolic Ca2+ ion concentration measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50559013(CHEMBL4760211)
Affinity DataEC50:  800nMAssay Description:Positive allosteric modulator activity at human mGlu2 receptor expressed in rat Chem-1 cells assessed as cytosolic Ca2+ ion concentration measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50558981(CHEMBL4780781)
Affinity DataEC50:  30nMAssay Description:Positive allosteric modulator activity at human mGlu2 receptor expressed in rat Chem-1 cells assessed as cytosolic Ca2+ ion concentration measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50581128(CHEMBL5093895)
Affinity DataEC50:  60nMAssay Description:Positive allosteric modulator activity at human mGlu2 receptor expressed in rat Chem-1 cells assessed as cytosolic Ca2+ ion concentration measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50581127(CHEMBL5086642)
Affinity DataEC50:  60nMAssay Description:Positive allosteric modulator activity at human mGlu2 receptor expressed in rat Chem-1 cells assessed as cytosolic Ca2+ ion concentration measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50581126(CHEMBL5074997)
Affinity DataEC50:  50nMAssay Description:Positive allosteric modulator activity at human mGlu2 receptor expressed in rat Chem-1 cells assessed as cytosolic Ca2+ ion concentration measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50581125(CHEMBL5090065)
Affinity DataEC50:  540nMAssay Description:Positive allosteric modulator activity at human mGlu2 receptor expressed in rat Chem-1 cells assessed as cytosolic Ca2+ ion concentration measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50581124(CHEMBL5083122)
Affinity DataEC50:  40nMAssay Description:Positive allosteric modulator activity at human mGlu2 receptor expressed in rat Chem-1 cells assessed as cytosolic Ca2+ ion concentration measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50581123(CHEMBL5091657)
Affinity DataEC50:  50nMAssay Description:Positive allosteric modulator activity at human mGlu2 receptor expressed in rat Chem-1 cells assessed as cytosolic Ca2+ ion concentration measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50581121(CHEMBL5074658)
Affinity DataEC50:  20nMAssay Description:Positive allosteric modulator activity at human mGlu2 receptor expressed in rat Chem-1 cells assessed as cytosolic Ca2+ ion concentration measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50581111(CHEMBL5081320)
Affinity DataEC50:  580nMAssay Description:Positive allosteric modulator activity at human mGlu2 receptor expressed in rat Chem-1 cells assessed as cytosolic Ca2+ ion concentration measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50581112(CHEMBL5091768)
Affinity DataEC50:  290nMAssay Description:Positive allosteric modulator activity at human mGlu2 receptor expressed in rat Chem-1 cells assessed as cytosolic Ca2+ ion concentration measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50581113(CHEMBL5073573)
Affinity DataEC50:  2.63E+3nMAssay Description:Positive allosteric modulator activity at human mGlu2 receptor expressed in rat Chem-1 cells assessed as cytosolic Ca2+ ion concentration measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50581114(CHEMBL5083201)
Affinity DataEC50:  390nMAssay Description:Positive allosteric modulator activity at human mGlu2 receptor expressed in rat Chem-1 cells assessed as cytosolic Ca2+ ion concentration measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50581115(CHEMBL5076606)
Affinity DataEC50:  350nMAssay Description:Positive allosteric modulator activity at human mGlu2 receptor expressed in rat Chem-1 cells assessed as cytosolic Ca2+ ion concentration measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50581116(CHEMBL5078863)
Affinity DataEC50:  310nMAssay Description:Positive allosteric modulator activity at human mGlu2 receptor expressed in rat Chem-1 cells assessed as cytosolic Ca2+ ion concentration measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50581117(CHEMBL5083384)
Affinity DataEC50:  250nMAssay Description:Positive allosteric modulator activity at human mGlu2 receptor expressed in rat Chem-1 cells assessed as cytosolic Ca2+ ion concentration measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50581118(CHEMBL5090853)
Affinity DataEC50:  250nMAssay Description:Positive allosteric modulator activity at human mGlu2 receptor expressed in rat Chem-1 cells assessed as cytosolic Ca2+ ion concentration measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50581119(CHEMBL5069547)
Affinity DataEC50:  280nMAssay Description:Positive allosteric modulator activity at human mGlu2 receptor expressed in rat Chem-1 cells assessed as cytosolic Ca2+ ion concentration measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50581120(CHEMBL5085978)
Affinity DataEC50:  30nMAssay Description:Positive allosteric modulator activity at human mGlu2 receptor expressed in rat Chem-1 cells assessed as cytosolic Ca2+ ion concentration measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50581122(CHEMBL5088821)
Affinity DataEC50:  60nMAssay Description:Positive allosteric modulator activity at human mGlu2 receptor expressed in rat Chem-1 cells assessed as cytosolic Ca2+ ion concentration measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandPNGBDBM50581128(CHEMBL5093895)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human ERG by patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandPNGBDBM50581124(CHEMBL5083122)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human ERG by patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandPNGBDBM50581123(CHEMBL5091657)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human ERG by patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandPNGBDBM50581121(CHEMBL5074658)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human ERG by patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandPNGBDBM50581120(CHEMBL5085978)
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibition of human ERG by patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandPNGBDBM50581122(CHEMBL5088821)
Affinity DataIC50: 5.60E+3nMAssay Description:Inhibition of human ERG by patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50558981(CHEMBL4780781)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50558981(CHEMBL4780781)
Affinity DataIC50: 7.70E+3nMAssay Description:Activation of PXR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50581127(CHEMBL5086642)
Affinity DataIC50: 8.30E+3nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandPNGBDBM50581119(CHEMBL5069547)
Affinity DataIC50: 8.60E+3nMAssay Description:Inhibition of human ERG by patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandPNGBDBM50581110(CHEMBL5074682)
Affinity DataIC50: 9.10E+3nMAssay Description:Inhibition of human ERG by patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50558981(CHEMBL4780781)
Affinity DataIC50: 9.40E+3nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandPNGBDBM50581112(CHEMBL5091768)
Affinity DataIC50: 9.50E+3nMAssay Description:Inhibition of human ERG by patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandPNGBDBM50581111(CHEMBL5081320)
Affinity DataIC50: 9.60E+3nMAssay Description:Inhibition of human ERG by patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50581127(CHEMBL5086642)
Affinity DataIC50: 1.00E+4nMAssay Description:Activation of PXR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50558981(CHEMBL4780781)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50581127(CHEMBL5086642)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50558981(CHEMBL4780781)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50581127(CHEMBL5086642)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50581127(CHEMBL5086642)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandPNGBDBM50581109(CHEMBL5076356)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of human ERG by patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandPNGBDBM50581117(CHEMBL5083384)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of human ERG by patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandPNGBDBM50581118(CHEMBL5090853)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of human ERG by patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandPNGBDBM50581127(CHEMBL5086642)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human ERG by patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
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