55 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
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Article Title
Organization
Structural Basis of Small-Molecule Aggregate Induced Inhibition of a Protein-Protein Interaction.
Janssen Research and Development
Prediction of anti-tumor chemical probes of a traditional Chinese medicine formula by HPLC fingerprinting combined with molecular docking.
The Second People'S Hospital of Fujian Provinc
Solvent Selection for Insoluble Ligands, a Challenge for Biological Assay Development: A TNF-α/SPD304 Study.
The Centre For Research and Technology of Thessaly (Ce.Re.Te.Th.)
Reaching for high-hanging fruit in drug discovery at protein-protein interfaces.
University of California San Francisco
Substituted isoquinolines and quinazolines as potential antiinflammatory agents. Synthesis and biological evaluation of inhibitors of tumor necrosis factor alpha.
University of California
Discovery of an Anti-TNF-α 9-mer Peptide from a T7 Phage Display Library for the Treatment of Inflammatory Bowel Disease.
Tongji University
It's ok to be outnumbered - sub-stoichiometric modulation of homomeric protein complexes.
Genentech
Imidazo[1,2-b]pyridazine as privileged scaffold in medicinal chemistry: An extensive review.
Universite de Tours
Recent developments of small molecules with anti-inflammatory activities for the treatment of acute lung injury.
Zhejiang University
Small molecule approaches to treat autoimmune and inflammatory diseases (Part III): Targeting cytokines and cytokine receptor complexes.
Roche Innovation Center Shanghai
Discovery of 3-OH-3-methylpipecolic hydroxamates: potent orally active inhibitors of aggrecanase and MMP-13.
Pfizer
Discovery of a Novel Potent and Selective Calcium Release-Activated Calcium Channel Inhibitor: 2,6-Difluoro-
Lupin
Identification and Validation of New Interleukin-2 Ligands Using DNA-Encoded Libraries.
Philochem
Structure based design and synthesis of novel Toll-like Receptor 2 (TLR 2) lipid antagonists.
Neuropore Therapies
Rationally designed TNF-α inhibitors: Identification of promising cytotoxic agents.
Guru Nanak Dev University
Development of Orally Efficacious Allosteric Inhibitors of TNFα via Fragment-Based Drug Design.
Abbvie
Fragment-to-Lead Medicinal Chemistry Publications in 2019.
Novartis Institutes For Biomedical Research
Biologic-like In Vivo Efficacy with Small Molecule Inhibitors of TNFα Identified Using Scaffold Hopping and Structure-Based Drug Design Approaches.
Bristol Myers Squibb
Discovery of an Orally Active Small-Molecule Tumor Necrosis Factor-α Inhibitor.
Huazhong University of Science and Technology
Development of Small-Molecules Targeting Receptor Activator of Nuclear Factor-κB Ligand (RANKL)-Receptor Activator of Nuclear Factor-κB (RANK) Protein-Protein Interaction by Structure-Based Virtual Screening and Hit Optimization.
Shanghai Jiaotong University School of Medicine
Structural modifications of thalidomide produce analogs with enhanced tumor necrosis factor inhibitory activity.
Celgene
Potent inhibition of tumor necrosis factor-alpha production by tetrafluorothalidomide and tetrafluorophthalimides.
Institute of Technology
Substituted xanthines, pteridinediones, and related compounds as potential antiinflammatory agents. Synthesis and biological evaluation of inhibitors of tumor necrosis factor alpha.
University of California
Beta-aryl-succinic acid hydroxamates as dual inhibitors of matrix metalloproteinases and tumor necrosis factor alpha converting enzyme.
Preclinical Research Novartis Pharma
Synthesis and in vitro evaluations of 6-(hetero)-aryl-imidazo[1,2-b]pyridazine-3-sulfonamide's as an inhibitor of TNF-α production.
Padmashri Vikhe Patil College of Arts
Synthesis and biological evaluation of pyridine-linked indanone derivatives: Potential agents for inflammatory bowel disease.
Yeungnam University
Synthesis, pH dependent, plasma and enzymatic stability of bergenin prodrugs for potential use against rheumatoid arthritis.
Csir-Indian Institute of Integrative Medicine
Selective inhibitors of Alpha2-containing isoforms of Na,K-ATPase and use thereof for reduction of intraocular pressure
Yeda Research and Development
Substituted pyrrolidines as factor XIa inhibitors for the treatment thromboembolic diseases
Ono Pharmaceutical
Augmenting moieties for anti-inflammatory compounds
Rutgers, The State University of New Jersey
MRSA Isolates from United States Hospitals Carry dfrG and dfrK Resistance Genes and Succumb to Propargyl-Linked Antifolates.
University of Connecticut
Pyrrolinone carboxamide compounds useful as endothelial lipase inhibitors
Bristol-Myers Squibb
7-deazapurine modulators of histone methyltransferase, and methods of use thereof
Epizyme
Cloning of a chick A3 adenosine receptor: characterization of ligand binding and receptor-effector coupling of chick A1 and A3 adenosine receptors.
University of Illinois At Chicago
Design, synthesis, and X-ray crystal structures of 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors.
Duquesne University
Rationally designed high-affinity 2-amino-6-halopurine heat shock protein 90 inhibitors that exhibit potent antitumor activity.
Biogen Idec
Inhibition of Src kinase activity by 4-anilino-7-thienyl-3-quinolinecarbonitriles.
Wyeth Research