Compile Data Set for Download or QSAR
Report error Found 12 Enz. Inhib. hit(s) with all data for entry = 50018260
TargetInterleukin-18(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50408848(CHEMBL1304177)
Affinity DataEC50:  250nMAssay Description:Inhibition of human IL-18 expressed in Escherichia coli BL21(DE3) cells incubated for 18 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetTumor necrosis factor(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50408849(CHEMBL5270115)
Affinity DataKd:  9.17E+4nMAssay Description:Inhibition of human TNF-alpha assessed as dissociation constant by ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetTumor necrosis factor(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50552392(CHEMBL4743779)
Affinity DataKd:  13nMAssay Description:Inhibition of human TNF-alpha assessed as dissociation constant incubated for 5 hrs by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetInterleukin-1 receptor type 1(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50408850(CHEMBL1626304 | DNDI1417291)
Affinity DataKd:  0.316nMAssay Description:Inhibition of human IL1-R1 assessed as dissociation constant incubated for 5 mins by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetInterleukin-36 gamma(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50408924(CHEMBL5288469)
Affinity DataKd:  68nMAssay Description:Inhibition of IL-36 gamma (unknown origin) assessed as dissociation constant by ITC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetInterleukin-4(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50409058(CHEMBL5266734)
Affinity DataKd:  1.80E+3nMAssay Description:Inhibition of IL-4 (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetInterleukin-4(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50409058(CHEMBL5266734)
Affinity DataEC50:  3.10E+3nMAssay Description:Inhibition of IL-4 (unknown origin) in human THP-1 cells assessed as inhibition of STAT6 phosphorylation by HEK-Blue assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetTumor necrosis factor(Mouse)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50552392(CHEMBL4743779)
Affinity DataIC50: 125nMAssay Description:Inhibition of mouse TNF-alpha in mouse L929 cells incubated for 18 hrs by CellTitreGlo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetInterleukin-2 receptor subunit alpha(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50147974(2-[3-METHYL-4-(N-METHYL-GUANIDINO)-BUTYRYLAMINO]-3...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of IL-2R alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetInterleukin-33(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50408853(CHEMBL5276831)
Affinity DataIC50: 4.20E+4nMAssay Description:Inhibition of human IL-33 incubated for 1 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetInterleukin-33(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50408852(CHEMBL5270750)
Affinity DataIC50: 4.30E+4nMAssay Description:Inhibition of human IL-33 incubated for 1 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetInterleukin-2(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50229786(5-[2,3-Dichloro-4-(5-{1-[2-((R)-2-guanidino-4-meth...)
Affinity DataIC50: 6.00E+4nMAssay Description:Inhibition of IL-2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed