Compile Data Set for Download or QSAR
Report error Found 24 Enz. Inhib. hit(s) with all data for entry = 50013455
TargetTumor necrosis factor(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50566080(CHEMBL4783333)
Affinity DataKd:  2.70E+3nMAssay Description:Binding affinity to biotinylated human TNFalpha trimer (77 to 233 residues) expressed in Escherichia coli BL21(DE3) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetTumor necrosis factor(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50566081(CHEMBL4778232)
Affinity DataKd:  74nMAssay Description:Binding affinity to biotinylated human TNFalpha trimer (77 to 233 residues) expressed in Escherichia coli BL21(DE3) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetTumor necrosis factor(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50566082(CHEMBL4779359)
Affinity DataKd:  2.40nMAssay Description:Binding affinity to biotinylated human TNFalpha trimer (77 to 233 residues) expressed in Escherichia coli BL21(DE3) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetTumor necrosis factor(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM3787(1-benzyl-1H-1,3-benzodiazole | 1-Phenylbenzimidazo...)
Affinity DataKd:  3.00E+5nMAssay Description:Binding affinity to biotinylated human TNFalpha trimer (77 to 233 residues) expressed in Escherichia coli BL21(DE3) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTumor necrosis factor(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50566083(CHEMBL4777805)
Affinity DataKd:  1.06E+5nMAssay Description:Binding affinity to biotinylated human TNFalpha trimer (77 to 233 residues) expressed in Escherichia coli BL21(DE3) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetTumor necrosis factor(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50566084(CHEMBL1507048)
Affinity DataKd:  3.25E+5nMAssay Description:Binding affinity to biotinylated human TNFalpha trimer (77 to 233 residues) expressed in Escherichia coli BL21(DE3) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetTumor necrosis factor(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50566085(CHEMBL4779860)
Affinity DataKd:  1.90E+4nMAssay Description:Binding affinity to biotinylated human TNFalpha trimer (77 to 233 residues) expressed in Escherichia coli BL21(DE3) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTumor necrosis factor(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50566086(CHEMBL4793441)
Affinity DataKd:  1.30nMAssay Description:Binding affinity to biotinylated human TNFalpha trimer (77 to 233 residues) expressed in Escherichia coli BL21(DE3) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetTumor necrosis factor(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50566087(CHEMBL4787790)
Affinity DataKd:  7.30nMAssay Description:Binding affinity to biotinylated human TNFalpha trimer (77 to 233 residues) expressed in Escherichia coli BL21(DE3) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetTumor necrosis factor(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50566088(CHEMBL4793924)
Affinity DataKd:  6.80nMAssay Description:Binding affinity to biotinylated human TNFalpha trimer (77 to 233 residues) expressed in Escherichia coli BL21(DE3) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetTumor necrosis factor(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50566079(CHEMBL4793685)
Affinity DataKd:  6.00E+4nMAssay Description:Binding affinity to biotinylated human TNFalpha trimer (77 to 233 residues) expressed in Escherichia coli BL21(DE3) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetTumor necrosis factor(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50566082(CHEMBL4779359)
Affinity DataIC50: 29nMAssay Description:Inhibition of probe-5 binding to human TNFalpha (77 to 233 residues) at 1 nM by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetTumor necrosis factor(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50566088(CHEMBL4793924)
Affinity DataIC50: 71nMAssay Description:Inhibition of probe-5 binding to human TNFalpha (77 to 233 residues) at 1 nM by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetTumor necrosis factor(Mouse)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50566088(CHEMBL4793924)
Affinity DataIC50: 99nMAssay Description:Inhibition of TNFalpha in mouse L929 cells exposed to compound incubated for 1 hr with mouse TNFalpha by luminescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetTumor necrosis factor(Mouse)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50566087(CHEMBL4787790)
Affinity DataIC50: 119nMAssay Description:Inhibition of TNFalpha in mouse L929 cells exposed to compound incubated for 1 hr with mouse TNFalpha by luminescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetTumor necrosis factor(Mouse)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50566082(CHEMBL4779359)
Affinity DataIC50: 128nMAssay Description:Inhibition of TNFalpha in mouse L929 cells exposed to compound incubated for 1 hr with mouse TNFalpha by luminescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetTumor necrosis factor(Mouse)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50566086(CHEMBL4793441)
Affinity DataIC50: 146nMAssay Description:Inhibition of TNFalpha in mouse L929 cells exposed to compound incubated for 1 hr with mouse TNFalpha by luminescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetTumor necrosis factor(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50566087(CHEMBL4787790)
Affinity DataIC50: 163nMAssay Description:Inhibition of probe-5 binding to human TNFalpha (77 to 233 residues) at 1 nM by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetTumor necrosis factor(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50566086(CHEMBL4793441)
Affinity DataIC50: 189nMAssay Description:Inhibition of probe-5 binding to human TNFalpha (77 to 233 residues) at 1 nM by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetTumor necrosis factor(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50566081(CHEMBL4778232)
Affinity DataIC50: 1.35E+3nMAssay Description:Inhibition of probe-5 binding to human TNFalpha (77 to 233 residues) at 1 nM by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetTumor necrosis factor(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50566085(CHEMBL4779860)
Affinity DataIC50: 5.30E+3nMAssay Description:Inhibition of probe-5 binding to human TNFalpha (77 to 233 residues) at 1 nM by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTumor necrosis factor(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50566080(CHEMBL4783333)
Affinity DataIC50: 7.96E+3nMAssay Description:Inhibition of probe-5 binding to human TNFalpha (77 to 233 residues) at 1 nM by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetTumor necrosis factor(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50566079(CHEMBL4793685)
Affinity DataIC50: 2.53E+4nMAssay Description:Inhibition of probe-5 binding to human TNFalpha (77 to 233 residues) at 1 nM by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetTumor necrosis factor(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM3787(1-benzyl-1H-1,3-benzodiazole | 1-Phenylbenzimidazo...)
Affinity DataIC50: 2.04E+5nMAssay Description:Inhibition of probe-5 binding to human TNFalpha (77 to 233 residues) at 1 nM by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)