Compile Data Set for Download or QSAR
Report error Found 25 Enz. Inhib. hit(s) with all data for entry = 50003605
TargetTumor necrosis factor(Human)
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50183784(N*4*-(2,2-Dimethyl-1-methylcarbamoyl-propyl)-N*1*-...)
Affinity DataIC50: 48nMAssay Description:Inhibitory activity against tumor necrosis factor alpha (TNF-alpha) production in LPS-stimulated human PBMCsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetTumor necrosis factor(Human)
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50240611((2S,3R)-N1-((S)-3,3-dimethyl-1-(methylamino)-1-oxo...)
Affinity DataIC50: 269nMAssay Description:Inhibitory activity against tumor necrosis factor alpha (TNF-alpha) production in LPS-stimulated human PBMCsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetTumor necrosis factor(Human)
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50473685(CHEMBL76297)
Affinity DataIC50: 928nMAssay Description:Inhibitory activity against tumor necrosis factor alpha (TNF-alpha) production in LPS-stimulated human PBMCsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetTumor necrosis factor(Human)
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50063917(CHEMBL279785 | marimastat | cid_119031 | (2S,3R)-N...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against tumor necrosis factor alpha (TNF-alpha) production in LPS-stimulated human PBMCsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetTumor necrosis factor(Human)
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50473686(CHEMBL433314)
Affinity DataIC50: 1.61E+3nMAssay Description:Inhibitory activity against tumor necrosis factor alpha (TNF-alpha) production in LPS-stimulated human PBMCsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50240611((2S,3R)-N1-((S)-3,3-dimethyl-1-(methylamino)-1-oxo...)
Affinity DataKi:  0.300nMAssay Description:Inhibitory potency against Matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50473686(CHEMBL433314)
Affinity DataKi:  0.300nMAssay Description:Inhibitory potency against Matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50183784(N*4*-(2,2-Dimethyl-1-methylcarbamoyl-propyl)-N*1*-...)
Affinity DataKi:  0.5nMAssay Description:Inhibitory potency against Matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50063917(CHEMBL279785 | marimastat | cid_119031 | (2S,3R)-N...)
Affinity DataKi:  0.600nMAssay Description:Inhibitory potency against Matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50473686(CHEMBL433314)
Affinity DataKi:  0.600nMAssay Description:Inhibitory potency against Matrix metalloprotease-1 (MMP-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50183784(N*4*-(2,2-Dimethyl-1-methylcarbamoyl-propyl)-N*1*-...)
Affinity DataKi:  0.600nMAssay Description:Inhibitory potency against Tumor necrosis factor alpha converting enzyme (TACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50063917(CHEMBL279785 | marimastat | cid_119031 | (2S,3R)-N...)
Affinity DataKi:  0.700nMAssay Description:Inhibitory potency against Matrix metalloprotease-1 (MMP-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50183784(N*4*-(2,2-Dimethyl-1-methylcarbamoyl-propyl)-N*1*-...)
Affinity DataKi:  0.900nMAssay Description:Inhibitory potency against Matrix metalloprotease-3 (MMP-3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50183784(N*4*-(2,2-Dimethyl-1-methylcarbamoyl-propyl)-N*1*-...)
Affinity DataKi:  1.10nMAssay Description:Inhibitory potency against Matrix metalloprotease-1 (MMP-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50240611((2S,3R)-N1-((S)-3,3-dimethyl-1-(methylamino)-1-oxo...)
Affinity DataKi:  2nMAssay Description:Inhibitory potency against Matrix metalloprotease-1 (MMP-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50473685(CHEMBL76297)
Affinity DataKi:  3.5nMAssay Description:Inhibitory potency against Matrix metalloprotease-1 (MMP-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50240611((2S,3R)-N1-((S)-3,3-dimethyl-1-(methylamino)-1-oxo...)
Affinity DataKi:  3.80nMAssay Description:Inhibitory potency against Tumor necrosis factor alpha converting enzyme (TACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50473685(CHEMBL76297)
Affinity DataKi:  4.80nMAssay Description:Inhibitory potency against Matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50473685(CHEMBL76297)
Affinity DataKi:  4.90nMAssay Description:Inhibitory potency against Tumor necrosis factor alpha converting enzyme (TACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50063917(CHEMBL279785 | marimastat | cid_119031 | (2S,3R)-N...)
Affinity DataKi:  6.30nMAssay Description:Inhibitory potency against Tumor necrosis factor alpha converting enzyme (TACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50063917(CHEMBL279785 | marimastat | cid_119031 | (2S,3R)-N...)
Affinity DataKi:  8.90nMAssay Description:Inhibitory potency against Matrix metalloprotease-3 (MMP-3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50473686(CHEMBL433314)
Affinity DataKi:  9.80nMAssay Description:Inhibitory potency against Matrix metalloprotease-3 (MMP-3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50473685(CHEMBL76297)
Affinity DataKi:  13nMAssay Description:Inhibitory potency against Matrix metalloprotease-3 (MMP-3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50473686(CHEMBL433314)
Affinity DataKi:  13nMAssay Description:Inhibitory potency against Tumor necrosis factor alpha converting enzyme (TACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50240611((2S,3R)-N1-((S)-3,3-dimethyl-1-(methylamino)-1-oxo...)
Affinity DataKi:  15nMAssay Description:Inhibitory potency against Matrix metalloprotease-3 (MMP-3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed