Compile Data Set for Download or QSAR
Report error Found 57 Enz. Inhib. hit(s) with all data for entry = 50018534
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Universite de Tours

Curated by ChEMBL
LigandPNGBDBM50228363(N-(2-(3-(piperazin-1-ylmethyl)imidazo[2,1-b]thiazo...)
Affinity DataEC50:  160nMAssay Description:Inhibition of SIRT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
Universite de Tours

Curated by ChEMBL
LigandPNGBDBM610463(US10774086, Example 14 | N-(4-(2-Methylmorpholino)...)
Affinity DataIC50: 0.0900nMAssay Description:Inhibition of GSK3alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Universite de Tours

Curated by ChEMBL
LigandPNGBDBM610463(US10774086, Example 14 | N-(4-(2-Methylmorpholino)...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Universite de Tours

Curated by ChEMBL
LigandPNGBDBM50609288(CHEMBL5268087)
Affinity DataIC50: 0.310nMAssay Description:Inhibition of TRKA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
Universite de Tours

Curated by ChEMBL
LigandPNGBDBM285634(US10077269, Example 104 | 3-(4-chloro-3,5-difluoro...)
Affinity DataIC50: 0.488nMAssay Description:Inhibition of human recombinant PDE4A incubated for 30 mins by Scintillation Proximity AssayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Universite de Tours

Curated by ChEMBL
LigandPNGBDBM50609297(CHEMBL5285673)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human recombinant JAK3 incubated for 3 hrs by caliper analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
LigandPNGBDBM288405(US10087187, Compound 106)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of PI3Kbeta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetProteinase-activated receptor 2(Human)
Universite de Tours

Curated by ChEMBL
LigandPNGBDBM50609292(CHEMBL5273903)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of PAR2 expressed in human HT-29 cells incubated for 30 mins by FLIPR Tetra system methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
LigandPNGBDBM193163(US9193736, 79)
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant PDE10A expressed in Sf9 cells incubated for 60 mins by scintillation counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
LigandPNGBDBM350389(US10208066, Compound 2 | US10208066, Compound 80 |...)
Affinity DataIC50: 1nMAssay Description:Inhibition of PI3Kbeta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Universite de Tours

Curated by ChEMBL
LigandPNGBDBM50322535(3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of BCR-ABL (unknown origin) expressed in mouse BaF3 cells assessed as cell growth inhibition incubated for 20 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Universite de Tours

Curated by ChEMBL
LigandPNGBDBM285634(US10077269, Example 104 | 3-(4-chloro-3,5-difluoro...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human recombinant PDE4B incubated for 30 mins by Scintillation Proximity AssayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Universite de Tours

Curated by ChEMBL
LigandPNGBDBM50609297(CHEMBL5285673)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of GST-fused human JAK1 incubated for 3 hrs by caliper analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetHepatocyte growth factor receptor(Human)
Universite de Tours

Curated by ChEMBL
LigandPNGBDBM50609287(CHEMBL5284720)
Affinity DataIC50: 3nMAssay Description:Inhibition of c-Met (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Human)
Universite de Tours

Curated by ChEMBL
LigandPNGBDBM285634(US10077269, Example 104 | 3-(4-chloro-3,5-difluoro...)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of human recombinant PDE4C incubated for 30 mins by Scintillation Proximity AssayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetNT-3 growth factor receptor(Human)
Universite de Tours

Curated by ChEMBL
LigandPNGBDBM136597(US8865698, 14 | US10047097, 14 | US9676783, 14 | U...)
Affinity DataIC50: 5nMAssay Description:Inhibition of TRKC (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Universite de Tours

Curated by ChEMBL
LigandPNGBDBM136597(US8865698, 14 | US10047097, 14 | US9676783, 14 | U...)
Affinity DataIC50: 5nMAssay Description:Inhibition of TRKA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Universite de Tours

Curated by ChEMBL
LigandPNGBDBM136597(US8865698, 14 | US10047097, 14 | US9676783, 14 | U...)
Affinity DataIC50: 5nMAssay Description:Inhibition of TRKB (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
Universite de Tours

Curated by ChEMBL
LigandPNGBDBM610450(US10774086, Example 1 | 2-Phenyl-N-(pyridin-3-yl)i...)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of GSK3alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
LigandPNGBDBM50609291(CHEMBL5281874)
Affinity DataIC50: 6nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
LigandPNGBDBM50609289(CHEMBL5282271)
Affinity DataIC50: 6nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Universite de Tours

Curated by ChEMBL
LigandPNGBDBM50364776(CHEMBL1952329 | CHEMBL1952141)
Affinity DataIC50: 7nMAssay Description:Inhibition of PIM1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Universite de Tours

Curated by ChEMBL
LigandPNGBDBM50322535(3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...)
Affinity DataIC50: 8.80nMAssay Description:Inhibition of Bcr-Abl T315I mutant (unknown origin) expressed in mouse BaF3 cells assessed as cell growth inhibition incubated for 20 mins by TR-FRET...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetMicrotubule-associated protein tau(Human)
Universite de Tours

Curated by ChEMBL
LigandPNGBDBM610463(US10774086, Example 14 | N-(4-(2-Methylmorpholino)...)
Affinity DataIC50: 9.20nMAssay Description:Inhibition of Tau (unknown origin) phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCalcium-dependent protein kinase 1(Plasmodium Falciparum)
Universite de Tours

Curated by ChEMBL
LigandPNGBDBM50609296(CHEMBL5282946)
Affinity DataIC50: 10nMAssay Description:Inhibition of Plasmodium falciparum CDPK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Universite de Tours

Curated by ChEMBL
LigandPNGBDBM11835(Cancer Res 676916 Compound K00135 | CHEMBL200528 |...)
Affinity DataIC50: 12nMAssay Description:Inhibition of PIM1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Universite de Tours

Curated by ChEMBL
LigandPNGBDBM50609295(CHEMBL5269179)
Affinity DataIC50: 16nMAssay Description:Inhibition of human recombinant CRF1 in HEK cell line incubated for 2 hrs by MicroBeta scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Universite de Tours

Curated by ChEMBL
LigandPNGBDBM610450(US10774086, Example 1 | 2-Phenyl-N-(pyridin-3-yl)i...)
Affinity DataIC50: 17nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
LigandPNGBDBM50609293(CHEMBL5279580)
Affinity DataIC50: 27nMAssay Description:Inhibition of PDE10A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCasein kinase I isoform epsilon(Human)
Universite de Tours

Curated by ChEMBL
LigandPNGBDBM50609299(CHEMBL5279523)
Affinity DataIC50: 57nMAssay Description:Inhibition of human CK1 epsilon incubated for 2 hrs by scintillation counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Universite de Tours

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 57nMAssay Description:Inhibition of human VEGFR2 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50397991(CHEMBL2180408)
Affinity DataIC50: 58nMAssay Description:Inhibition of PDE10A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
LigandPNGBDBM50609289(CHEMBL5282271)
Affinity DataIC50: 70nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Universite de Tours

Curated by ChEMBL
LigandPNGBDBM50609291(CHEMBL5281874)
Affinity DataIC50: 75nMAssay Description:Inhibition of Akt phosphorylation in human HCT-116 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
LigandPNGBDBM350389(US10208066, Compound 2 | US10208066, Compound 80 |...)
Affinity DataIC50: 87nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Universite de Tours

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 90nMAssay Description:Inhibition of PDGFRbeta (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Universite de Tours

Curated by ChEMBL
LigandPNGBDBM50609294(CHEMBL5280146)
Affinity DataIC50: 120nMAssay Description:Inhibition of human recombinant CRF1 in HEK cell line incubated for 2 hrs by MicroBeta scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Universite de Tours

Curated by ChEMBL
LigandPNGBDBM285634(US10077269, Example 104 | 3-(4-chloro-3,5-difluoro...)
Affinity DataIC50: 145nMAssay Description:Inhibition of human recombinant PDE4D incubated for 30 mins by Scintillation Proximity AssayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
LigandPNGBDBM50609289(CHEMBL5282271)
Affinity DataIC50: 150nMAssay Description:Inhibition of PI3Kbeta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
LigandPNGBDBM50609289(CHEMBL5282271)
Affinity DataIC50: 157nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
LigandPNGBDBM350389(US10208066, Compound 2 | US10208066, Compound 80 |...)
Affinity DataIC50: 168nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Universite de Tours

Curated by ChEMBL
LigandPNGBDBM13530(cid_5291 | STI571 | N-(4-methyl-3-{[4-(pyridin-3-y...)
Affinity DataIC50: 260nMAssay Description:Inhibition of BCR-ABL (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
Universite de Tours

Curated by ChEMBL
LigandPNGBDBM50364776(CHEMBL1952329 | CHEMBL1952141)
Affinity DataIC50: 363nMAssay Description:Inhibition of PIM2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
LigandPNGBDBM288405(US10087187, Compound 106)
Affinity DataIC50: 372nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetTumor necrosis factor(Human)
Universite de Tours

Curated by ChEMBL
LigandPNGBDBM14361(Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...)
Affinity DataIC50: 500nMAssay Description:Inhibition of TNFalpha in LPS-stimulated human mononuclear cell line by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetMicrotubule-associated protein tau(Human)
Universite de Tours

Curated by ChEMBL
LigandPNGBDBM610450(US10774086, Example 1 | 2-Phenyl-N-(pyridin-3-yl)i...)
Affinity DataIC50: 660nMAssay Description:Inhibition of Tau (unknown origin) phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Universite de Tours

Curated by ChEMBL
LigandPNGBDBM50399537(CHEMBL2180604 | US20250129067, Compound TAK-593)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PDGFRbeta (unknown origin) incubated for 5 mins by Alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
LigandPNGBDBM50609290(CHEMBL5274346)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
LigandPNGBDBM350389(US10208066, Compound 2 | US10208066, Compound 80 |...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
Universite de Tours

Curated by ChEMBL
LigandPNGBDBM11835(Cancer Res 676916 Compound K00135 | CHEMBL200528 |...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of PIM2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
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