87 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
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Helixconstraints and amino acid substitution in GLP-1 increase cAMP and insulin secretion but not beta-arrestin 2 signaling.
The University of Queensland
Electrophilic Helical Peptides That Bond Covalently, Irreversibly, and Selectively in a Protein-Protein Interaction Site.
The University of Queensland
Evaluation of known and novel inhibitors of Orai1-mediated store operated Ca
The University of Queensland
Identification, Synthesis, and Biological Evaluation of the Major Human Metabolite of NLRP3 Inflammasome Inhibitor MCC950.
The University of Queensland
Benzylamide antagonists of protease activated receptor 2 with anti-inflammatory activity.
The University of Queensland
Cyclic alpha-conotoxin peptidomimetic chimeras as potent GLP-1R agonists.
The University of Queensland
First Crystal Structures of Mycobacterium tuberculosis 6-Oxopurine Phosphoribosyltransferase: Complexes with GMP and Pyrophosphate and with Acyclic Nucleoside Phosphonates Whose Prodrugs Have Antituberculosis Activity.
The University of Queensland
Aza-acyclic nucleoside phosphonates containing a second phosphonate group as inhibitors of the human, Plasmodium falciparum and vivax 6-oxopurine phosphoribosyltransferases and their prodrugs as antimalarial agents.
The University of Queensland
Potent heterocyclic ligands for human complement c3a receptor.
The University of Queensland
The applications of binuclear metallohydrolases in medicine: recent advances in the design and development of novel drug leads for purple acid phosphatases, metallo-ß-lactamases and arginases.
The University of Queensland
Australian marine sponge alkaloids as a new class of glycine-gated chloride channel receptor modulator.
The University of Queensland
Acyclic nucleoside phosphonates containing a second phosphonate group are potent inhibitors of 6-oxopurine phosphoribosyltransferases and have antimalarial activity.
The University of Queensland
Sulfonylureas have antifungal activity and are potent inhibitors of Candida albicans acetohydroxyacid synthase.
The University of Queensland
A focused sulfated glycoconjugate Ugi library for probing heparan sulfate-binding angiogenic growth factors.
The University of Queensland
Synthesis, biological activity and structure-activity relationship of endomorphin-1/substance P derivatives.
The University of Queensland
Synthesis and biological evaluation of an orally active glycosylated endomorphin-1.
The University of Queensland
chi-Conotoxin and tricyclic antidepressant interactions at the norepinephrine transporter define a new transporter model.
The University of Queensland
Countering cooperative effects in protease inhibitors using constrained beta-strand-mimicking templates in focused combinatorial libraries.
The University of Queensland
Synthesis, stability, antiviral activity, and protease-bound structures of substrate-mimicking constrained macrocyclic inhibitors of HIV-1 protease.
The University of Queensland
Synthesis, modelling and kinetic assays of potent inhibitors of purple acid phosphatase.
The University of Queensland
Modulating oxytocin activity and plasma stability by disulfide bond engineering.
The University of Queensland
Antimalarial histone deacetylase inhibitors containing cinnamate or NSAID components.
The University of Queensland
Novel agonists and antagonists for human protease activated receptor 2.
The University of Queensland
DNA gyrase from the albicidin producer Xanthomonas albilineans has multiple-antibiotic-resistance and unusual enzymatic properties.
The University of Queensland
Development and characterization of new inhibitors of the human and mouse hematopoietic prostaglandin D(2) synthases.
The University of Queensland
Selective hexapeptide agonists and antagonists for human complement C3a receptor.
The University of Queensland
Ircinialactams: subunit-selective glycine receptor modulators from Australian sponges of the family Irciniidae.
The University of Queensland
Structure-activity relationships for substrate-based inhibitors of human complement factor B.
The University of Queensland
Noncovalent tripeptidyl benzyl- and cyclohexyl-amine inhibitors of the cysteine protease caspase-1.
The University of Queensland
Omega-conotoxin GVIA mimetics based on an anthranilamide core: effect of variation in ammonium side chain lengths and incorporation of fluorine.
The University of Queensland
Identification and characterisation of new inhibitors for the human hematopoietic prostaglandin D2 synthase.
The University of Queensland
Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: a new class of antimalarial therapeutics.
The University of Queensland
Inhibition of purple acid phosphatase with alpha-alkoxynaphthylmethylphosphonic acids.
The University of Queensland
Inhibitors for metallo-β-lactamases from the B1 and B3 subgroups provide an avenue to combat a major mechanism of antibiotic resistance.
The University of Queensland
Engineering the Cyclization Loop of MCoTI-II Generates Targeted Cyclotides that Potently Inhibit Factor XIIa.
The University of Queensland
Glenthmycins A-M: Macrocyclic Spirotetronate Polyketide Antibacterials from the Australian Pasture Plant-Derived
The University of Queensland
Posttranslational modifications of α-conotoxins: sulfotyrosine and C-terminal amidation stabilise structures and increase acetylcholine receptor binding.
The University of Queensland
Glenthenamines A-F: Enamine Pyranonaphthoquinones from the Australian Pasture Plant Derived
The University of Queensland
Modifying a Hydroxyl Patch in Glucagon-like Peptide 1 Produces Biased Agonists with Unique Signaling Profiles.
The University of Queensland
Synthesis of full-length homodimer αD-VxXXB that targets human α7 nicotinic acetylcholine receptors.
The University of Queensland
Late-Stage Functionalization with Cysteine Staples Generates Potent and Selective Melanocortin Receptor-1 Agonists.
The University of Queensland
Inhibition of N-type calcium ion channels by tricyclic antidepressants - experimental and theoretical justification for their use for neuropathic pain.
The University of Queensland
Development of Potent and Selective Agonists for Complement C5a Receptor 1 with In Vivo Activity.
The University of Queensland
Neochrysosporazines: Precursor-Directed Biosynthesis Defines a Marine-Derived Fungal Natural Product P-Glycoprotein Inhibitory Pharmacophore.
The University of Queensland
Bioactive Cyclization Optimizes the Affinity of a Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Peptide Inhibitor.
The University of Queensland
Melanocortin 1 Receptor Agonists Based on a Bivalent, Bicyclic Peptide Framework.
The University of Queensland
Chemical and functional identification and characterization of novel sulfated alpha-conotoxins from the cone snail Conus anemone.
The University of Queensland
Xanthine-Guanine-Hypoxanthine Phosphoribosyltransferase-A Putative Target for Drug Discovery against Gastrointestinal Tract Infections.
The University of Queensland
HDAC7 Inhibition by Phenacetyl and Phenylbenzoyl Hydroxamates.
The University of Queensland
The neuronal calcium ion channel activity of constrained analogues of MONIRO-1.
The University of Queensland
Bicyclic Helical Peptides as Dual Inhibitors Selective for Bcl2A1 and Mcl-1 Proteins.
The University of Queensland
The E15R Point Mutation in Scorpion Toxin Cn2 Uncouples Its Depressant and Excitatory Activities on Human Na
The University of Queensland
Engineering of a Novel Simplified Human Insulin-Like Peptide 5 Agonist.
The University of Queensland
Rapid discovery of a selective butyrylcholinesterase inhibitor using structure-based virtual screening.
The University of Queensland
Achiral Derivatives of Hydroxamate AR-42 Potently Inhibit Class I HDAC Enzymes and Cancer Cell Proliferation.
The University of Queensland
Chrysosporazines F-M: P-Glycoprotein Inhibitory Phenylpropanoid Piperazines from an Australian Marine Fish Derived Fungus,
The University of Queensland
Discovery and Structure-Activity Relationships of a Highly Selective Butyrylcholinesterase Inhibitor by Structure-Based Virtual Screening.
The University of Queensland
Substrate-Guided Design of Selective FXIIa Inhibitors Based on the Plant-Derived Momordica cochinchinensis Trypsin Inhibitor-II (MCoTI-II) Scaffold.
The University of Queensland
Binding Loop Substitutions in the Cyclic Peptide SFTI-1 Generate Potent and Selective Chymase Inhibitors.
The University of Queensland
Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma.
The University of Queensland
Synthesis, evaluation and structural investigations of potent purple acid phosphatase inhibitors as drug leads for osteoporosis.
The University of Queensland
Amino Acid Scanning at P5' within the Bowman-Birk Inhibitory Loop Reveals Specificity Trends for Diverse Serine Proteases.
The University of Queensland
Trivirensols: Selectively Bacteriostatic Sesquiterpene Trimers from the Australian Termite Nest-Derived Fungus
The University of Queensland
Potent, Selective, and Cell-Penetrating Inhibitors of Kallikrein-Related Peptidase 4 Based on the Cyclic Peptide MCoTI-II.
The University of Queensland
Iterative Optimization of the Cyclic Peptide SFTI-1 Yields Potent Inhibitors of Neutrophil Proteinase 3.
The University of Queensland
Potent complement C3a receptor agonists derived from oxazole amino acids: Structure-activity relationships.
The University of Queensland
Determination of the α-conotoxin Vc1.1 binding site on the α9α10 nicotinic acetylcholine receptor.
The University of Queensland
3-mercapto-1,2,4-triazoles and N-acylated thiosemicarbazides as metallo-β-lactamase inhibitors.
The University of Queensland
Purple acid phosphatase inhibitors as leads for osteoporosis chemotherapeutics.
The University of Queensland
Antifungal benzo[b]thiophene 1,1-dioxide IMPDH inhibitors exhibit pan-assay interference (PAINS) profiles.
The University of Queensland
Pyrrolidine nucleoside bisphosphonates as antituberculosis agents targeting hypoxanthine-guanine phosphoribosyltransferase.
The University of Queensland
Chemical Approaches to Modulating Complement-Mediated Diseases.
The University of Queensland
Synthesis of deuterium-labelled analogues of NLRP3 inflammasome inhibitor MCC950.
The University of Queensland
Engineering potent mesotrypsin inhibitors based on the plant-derived cyclic peptide, sunflower trypsin inhibitor-1.
The University of Queensland
Structure-activity relationship study and optimisation of 2-aminopyrrole-1-benzyl-4,5-diphenyl-1H-pyrrole-3-carbonitrile as a broad spectrum metallo-β-lactamase inhibitor.
The University of Queensland
Design of Potent and Selective Cathepsin G Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold.
The University of Queensland
Development of Novel Melanocortin Receptor Agonists Based on the Cyclic Peptide Framework of Sunflower Trypsin Inhibitor-1.
The University of Queensland
Substituted imidazolones, compositions containing such compounds and methods of use
Merck Sharp & Dohme