BindingDB

The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 3.1M data for 1.3M Compounds and 9.6K Targets. Of those, 1.5M data for 698K Compounds and 4.7K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

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To help with training and testing AI and other models, BindingDB downloads and search results now provide the publication date and BindingDB curation date of each measurement.

33 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-ß hydrolysis.EBI
University of Lille
Thiol-based angiotensin-converting enzyme 2 inhibitors: P1 modifications for the exploration of the S1 subsite.EBI
Glaxosmithkline
Angiotensin converting enzyme inhibitors. 10. Aryl sulfonamide substituted N-[1-carboxy-3-phenylpropyl]-L-alanyl-L-proline derivatives as novel antihypertensives.EBI
Rorer Central Research
Synthesis and biological evaluation of phosphonamidate peptide inhibitors of enkephalinase and angiotensin-converting enzyme.EBI
TBA
Novel synthesis of (S)-1-[5-(benzoylamino)-1,4-dioxo-6-phenylhexyl]-L-proline and analogues: potent angiotensin converting enzyme inhibitors.EBI
TBA
Synthesis and angiotensin-converting enzyme inhibitory activity of 3-(Mercaptomethyl)-2-oxo-1-pyrrolidineacetic acids and 3-(Mercaptomethyl)-2-oxo-1-piperidineacetic acids.EBI
TBA
 
Dual inhibition of neutral endopeptidase and angiotensin-converting enzyme by N-phosphonomethyl and N-carboxyalkyl dipeptidesEBI
TBA
 
4-Substituted proline derivatives that inhibit angiotensin converting enzyme and neutral endopeptidase 24.11.EBI
TBA
Phage-encoded combinatorial chemical libraries based on bicyclic peptides.EBI
Laboratory of Molecular Biology, Medical Research Council
 
Dual inhibition of angiotensin-converting enzyme and neutral endopeptidase by tricyclic benzazepinone thiolsEBI
TBA
 
α-Mercaptoacyl dipeptides that inhibit angiotensin converting enzyme and neutral endopeptidase 24.11EBI
TBA
 
Peptide mimics of glycylproline as inhibitors of prolidaseEBI
TBA
Thiol-based angiotensin-converting enzyme 2 inhibitors: P1' modifications for the exploration of the S1' subsite.EBI
Glaxosmithkline
The evolution of small molecule enzyme activators.EBI
University of Nebraska
Structure-Guided Chemical Optimization of Bicyclic Peptide (EBI
Bicycletx
Bench-to-bedside: Innovation of small molecule anti-SARS-CoV-2 drugs in China.EBI
Qufu Normal University
Thorectidiol A Isolated from the Marine Sponge EBI
University of British Columbia
Inhibitors of SARS-CoV-2 Entry: Current and Future Opportunities.EBI
Shandong University
The race to treat COVID-19: Potential therapeutic agents for the prevention and treatment of SARS-CoV-2.EBI
American University of Ras Al Khaimah
Enzyme inhibition as a potential therapeutic strategy to treat COVID-19 infection.EBI
Kingston University
Discovery of honokiol thioethers containing 1,3,4-oxadiazole moieties as potential α-glucosidase and SARS-CoV-2 entry inhibitors.EBI
Zhengzhou University
Synthetic Peptides That Antagonize the Angiotensin-Converting Enzyme-2 (ACE-2) Interaction with SARS-CoV-2 Receptor Binding Spike Protein.EBI
University of Groningen
Colloidal Aggregators in Biochemical SARS-CoV-2 Repurposing Screens.EBI
University of California San Francisco (Ucsf)
Discovery of Cyclic Boronic Acid QPX7728, an Ultrabroad-Spectrum Inhibitor of Serine and Metallo-β-lactamases.EBI
Qpex Biopharma
The Other Angiotensin II Receptor: ATEBI
Centre Hospitalier Universitaire Vaudois (Chuv) and University of Lausanne (Unil
Angiotensin converting enzyme inhibitors: modifications of a tripeptide analogue.EBI
TBA
The first mechanism-based inactivators for angiotensin-converting enzyme.EBI
Baxter Diagnostics
Pyrazolo[1,5a]pyrimidine derivatives as IRAK4 modulatorsBDB
Genentech
Bicyclic lactams and methods of use thereofBDB
Genentech
Thiazolidinone compounds and use thereofBDB
National Health Research Institute
Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitorsBDB
Array Biopharma
Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design.BDB
Vernalis (R&D)
Anilinopyrazole as selective CDK2 inhibitors: design, synthesis, biological evaluation, and X-ray crystallographic analysis.BDB
Glaxosmithkline