Compile Data Set for Download or QSAR
Report error Found 14 Enz. Inhib. hit(s) with all data for entry = 50007974
TargetProto-oncogene Mas(Human)
Centre Hospitalier Universitaire Vaudois (Chuv) and University of Lausanne (Unil

Curated by ChEMBL
LigandPNGBDBM50514583(CHEMBL4578721)
Affinity DataIC50: 0.300nMAssay Description:Antagonist activity at N-terminal c-Myc tagged human MasR expressed in HEK293T cells by cAMP accumulation based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme 2(Human)
Centre Hospitalier Universitaire Vaudois (Chuv) and University of Lausanne (Unil

Curated by ChEMBL
LigandPNGBDBM21489(MLN4760 | (2S)-2-{[(1S)-1-carboxy-2-{1-[(3,5-dichl...)
Affinity DataIC50: 0.440nMAssay Description:Inhibition of ACE2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor A(Rat)
Centre Hospitalier Universitaire Vaudois (Chuv) and University of Lausanne (Unil

Curated by ChEMBL
LigandPNGBDBM50369183(L-163491 | CHEMBL290214)
Affinity DataIC50: 1.40nMAssay Description:Displacement of [125I]Ang II from AT1 receptor in rat liver membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetProto-oncogene Mas(Human)
Centre Hospitalier Universitaire Vaudois (Chuv) and University of Lausanne (Unil

Curated by ChEMBL
LigandPNGBDBM50514584(CHEMBL4303593)
Affinity DataIC50: 21nMAssay Description:Agonist activity at N-terminal c-Myc tagged human MasR expressed in HEK293T cells assessed as reduction in forskolin-induced cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Human)
Centre Hospitalier Universitaire Vaudois (Chuv) and University of Lausanne (Unil

Curated by ChEMBL
LigandPNGBDBM50049182(PD-126055 | (S)-5-Benzyloxy-2-diphenylacetyl-6-met...)
Affinity DataIC50: 39nMAssay Description:Inhibition of human AT1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetType-2 angiotensin II receptor(Rat)
Centre Hospitalier Universitaire Vaudois (Chuv) and University of Lausanne (Unil

Curated by ChEMBL
LigandPNGBDBM50514582(CHEMBL155836)
Affinity DataIC50: 75nMAssay Description:Inhibition of rat AT2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Human)
Centre Hospitalier Universitaire Vaudois (Chuv) and University of Lausanne (Unil

Curated by ChEMBL
LigandPNGBDBM50514585(CHEMBL4448705)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human AT1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetType-2 angiotensin II receptor(Human)
Centre Hospitalier Universitaire Vaudois (Chuv) and University of Lausanne (Unil

Curated by ChEMBL
LigandPNGBDBM50049182(PD-126055 | (S)-5-Benzyloxy-2-diphenylacetyl-6-met...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human AT2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetType-1 angiotensin II receptor A(Rat)
Centre Hospitalier Universitaire Vaudois (Chuv) and University of Lausanne (Unil

Curated by ChEMBL
LigandPNGBDBM50514582(CHEMBL155836)
Affinity DataIC50: 2.90E+6nMAssay Description:Inhibition of rat AT1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor A(Rat)
Centre Hospitalier Universitaire Vaudois (Chuv) and University of Lausanne (Unil

Curated by ChEMBL
LigandPNGBDBM50049189(butyl 3-(4-((2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b...)
Affinity DataKi:  3.90nMAssay Description:Displacement of [125I]Ang II from AT1 receptor in rat liver membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Human)
Centre Hospitalier Universitaire Vaudois (Chuv) and University of Lausanne (Unil

Curated by ChEMBL
LigandPNGBDBM50282396(PD-123319 | (S)-1-(4-Dimethylamino-3-methyl-benzyl...)
Affinity DataKi:  12nMAssay Description:Inhibition of human AT1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor A(Rat)
Centre Hospitalier Universitaire Vaudois (Chuv) and University of Lausanne (Unil

Curated by ChEMBL
LigandPNGBDBM50514581(CHEMBL1885579)
Affinity DataKi:  1.70E+3nMAssay Description:Displacement of [125I]Ang II from AT1 receptor in rat SMC membranes incubated for 60 mins by gamma counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor A(Rat)
Centre Hospitalier Universitaire Vaudois (Chuv) and University of Lausanne (Unil

Curated by ChEMBL
LigandPNGBDBM50156173(butyl 3-(4-((1H-imidazol-1-yl)methyl)phenyl)-5-iso...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [125I]Ang II from AT1 receptor in rat liver membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetType-2 angiotensin II receptor(Human)
Centre Hospitalier Universitaire Vaudois (Chuv) and University of Lausanne (Unil

Curated by ChEMBL
LigandPNGBDBM50282396(PD-123319 | (S)-1-(4-Dimethylamino-3-methyl-benzyl...)
Affinity DataKi:  1.20E+5nMAssay Description:Inhibition of human AT2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed