115 articles for thisTarget
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Discovery of N-Substituted (2-Phenylcyclopropyl)methylamines as Functionally Selective Serotonin 2C Receptor Agonists for Potential Use as Antipsychotic Medications.
University of Illinois At Chicago
Design and Synthesis of Mercaptoacetamides as Potent, Selective, and Brain Permeable Histone Deacetylase 6 Inhibitors.
University of Illinois At Chicago
Magnetic Microbead Affinity Selection Screening (MagMASS) of Botanical Extracts for Inhibitors of 15-Lipoxygenase.
University of Illinois At Chicago
Synthesis and biological evaluation of novel hybrids of highly potent and selectivea4ß2-Nicotinic acetylcholine receptor (nAChR) partial agonists.
University of Illinois At Chicago
Development of Small Molecules that Specifically Inhibit the D-loop Activity of RAD51.
University of Illinois At Chicago
Further Advances in Optimizing (2-Phenylcyclopropyl)methylamines as Novel Serotonin 2C Agonists: Effects on Hyperlocomotion, Prepulse Inhibition, and Cognition Models.
University of Illinois At Chicago
Selective Human Estrogen Receptor Partial Agonists (ShERPAs) for Tamoxifen-Resistant Breast Cancer.
University of Illinois At Chicago
Probing the structural requirements of non-electrophilic naphthalene-based Nrf2 activators.
University of Illinois At Chicago
Optimization of 2-phenylcyclopropylmethylamines as selective serotonin 2C receptor agonists and their evaluation as potential antipsychotic agents.
University of Illinois At Chicago
Recent developments in novel antidepressants targetinga4ß2-nicotinic acetylcholine receptors.
University of Illinois At Chicago
Enantiopure Cyclopropane-Bearing Pyridyldiazabicyclo[3.3.0]octanes as Selectivea4ß2-nAChR Ligands.
University of Illinois At Chicago
Structure-guided development of deoxycytidine kinase inhibitors with nanomolar affinity and improved metabolic stability.
University of Illinois At Chicago
Synthesis and pharmacological characterization of bivalent ligands of epibatidine at neuronal nicotinic acetylcholine receptors.
University of Illinois At Chicago
Development and therapeutic implications of selective histone deacetylase 6 inhibitors.
University of Illinois At Chicago
Chemistry, pharmacology, and behavioral studies identify chiral cyclopropanes as selectivea4ß2-nicotinic acetylcholine receptor partial agonists exhibiting an antidepressant profile. Part II.
University of Illinois At Chicago
Design, synthesis, and biological activity of diaryl ether inhibitors of Toxoplasma gondii enoyl reductase.
University of Illinois At Chicago
Structural analogs of huperzine A improve survival in guinea pigs exposed to soman.
University of Illinois At Chicago
Chemistry and pharmacological characterization of novel nitrogen analogues of AMOP-H-OH (Sazetidine-A, 6-[5-(azetidin-2-ylmethoxy)pyridin-3-yl]hex-5-yn-1-ol) asa4ß2-nicotinic acetylcholine receptor-selective partial agonists.
University of Illinois At Chicago
Activity-guided isolation of steroidal alkaloid antiestrogen-binding site inhibitors from Pachysandra procumbens.
University of Illinois At Chicago
Amino acid side chain descriptors for quantitative structure-activity relationship studies of peptide analogues.
University of Illinois At Chicago
Three-dimensional molecular shape analysis-quantitative structure-activity relationship of a series of cholecystokinin-A receptor antagonists.
University of Illinois At Chicago
Discovery of highly potent and selectivea4ß2-nicotinic acetylcholine receptor (nAChR) partial agonists containing an isoxazolylpyridine ether scaffold that demonstrate antidepressant-like activity. Part II.
University of Illinois At Chicago
Selective histone deacetylase 6 inhibitors bearing substituted urea linkers inhibit melanoma cell growth.
University of Illinois At Chicago
Insights into the structural determinants required for high-affinity binding of chiral cyclopropane-containing ligands toa4ß2-nicotinic acetylcholine receptors: an integrated approach to behaviorally active nicotinic ligands.
University of Illinois At Chicago
Novel histone deacetylase 8 ligands without a zinc chelating group: exploring an 'upside-down' binding pose.
University of Illinois At Chicago
Identification of novela4ß2-nicotinic acetylcholine receptor (nAChR) agonists based on an isoxazole ether scaffold that demonstrate antidepressant-like activity.
University of Illinois At Chicago
Structural and enzymatic analyses reveal the binding mode of a novel series of Francisella tularensis enoyl reductase (FabI) inhibitors.
University of Illinois At Chicago
Design, synthesis, modeling, biological evaluation and photoaffinity labeling studies of novel series of photoreactive benzamide probes for histone deacetylase 2.
University of Illinois At Chicago
Chemistry and behavioral studies identify chiral cyclopropanes as selectivea4ß2-nicotinic acetylcholine receptor partial agonists exhibiting an antidepressant profile.
University of Illinois At Chicago
Second-generation histone deacetylase 6 inhibitors enhance the immunosuppressive effects of Foxp3+ T-regulatory cells.
University of Illinois At Chicago
Constituents of the bark and twigs of Artocarpus dadah with cyclooxygenase inhibitory activity.
University of Illinois At Chicago
Design and synthesis of 2-pyridones as novel inhibitors of the Bacillus anthracis enoyl-ACP reductase.
University of Illinois At Chicago
5-tert-butyl-N-pyrazol-4-yl-4,5,6,7-tetrahydrobenzo[d]isoxazole-3-carboxamide derivatives as novel potent inhibitors of Mycobacterium tuberculosis pantothenate synthetase: initiating a quest for new antitubercular drugs.
University of Illinois At Chicago
Synthesis, molecular modeling, and biological studies of novel piperidine-based analogues of cocaine: evidence of unfavorable interactions proximal to the 3alpha-position of the piperidine ring.
University of Illinois At Chicago
Rigid phencyclidine analogues. Binding to the phencyclidine and sigma 1 receptors.
University of Illinois At Chicago
Potential anti-AIDS naphthalenesulfonic acid derivatives. Synthesis and inhibition of HIV-1 induced cytopathogenesis and HIV-1 and HIV-2 reverse transcriptase activities.
University of Illinois At Chicago
Structure-based design and synthesis of novel thrombin inhibitors based on phosphinic peptide mimetics.
University of Illinois At Chicago
Structure based design: novel spirocyclic ethers as nonpeptidal P2-ligands for HIV protease inhibitors.
University of Illinois At Chicago
Design, synthesis, docking, and biological evaluation of novel diazide-containing isoxazole- and pyrazole-based histone deacetylase probes.
University of Illinois At Chicago
Discovery of isoxazole analogues of sazetidine-A as selectivea4ß2-nicotinic acetylcholine receptor partial agonists for the treatment of depression.
University of Illinois At Chicago
Identification and development of novel inhibitors of Toxoplasma gondii enoyl reductase.
University of Illinois At Chicago
Synthesis and biological evaluation of triazol-4-ylphenyl-bearing histone deacetylase inhibitors as anticancer agents.
University of Illinois At Chicago
Click synthesis of estradiol-cyclodextrin conjugates as cell compartment selective estrogens.
University of Illinois At Chicago
Binding ensemble profiling with photoaffinity labeling (BEProFL) approach: mapping the binding poses of HDAC8 inhibitors.
University of Illinois At Chicago
Isoxazole moiety in the linker region of HDAC inhibitors adjacent to the Zn-chelating group: effects on HDAC biology and antiproliferative activity.
University of Illinois At Chicago
From a natural product lead to the identification of potent and selective benzofuran-3-yl-(indol-3-yl)maleimides as glycogen synthase kinase 3beta inhibitors that suppress proliferation and survival of pancreatic cancer cells.
University of Illinois At Chicago
Selective 5-hydroxytryptamine 2C receptor agonists derived from the lead compound tranylcypromine: identification of drugs with antidepressant-like action.
University of Illinois At Chicago
Molecular modeling, synthesis, and activity studies of novel biaryl and fused-ring BACE1 inhibitors.
University of Illinois At Chicago
Structure-activity relationships of compounds targeting mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate synthase.
University of Illinois At Chicago
Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: a new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6.
University of Illinois At Chicago
Xanthones from the botanical dietary supplement mangosteen (Garcinia mangostana) with aromatase inhibitory activity.
University of Illinois At Chicago
Interference by naturally occurring fatty acids in a noncellular enzyme-based aromatase bioassay.
University of Illinois At Chicago
Serotonergic activity-guided phytochemical investigation of the roots of Angelica sinensis.
University of Illinois At Chicago
Two new stilbene dimer glucosides from grape (Vitis vinifera) cell cultures.
University of Illinois At Chicago
Functional differences in epigenetic modulators-superiority of mercaptoacetamide-based histone deacetylase inhibitors relative to hydroxamates in cortical neuron neuroprotection studies.
University of Illinois At Chicago
Nicotinamide Phosphoribosyltransferase Positive Allosteric Modulators Attenuate Neuronal Oxidative Stress.
University of Illinois At Chicago
What We Have Gained from Ibogaine: α3β4 Nicotinic Acetylcholine Receptor Inhibitors as Treatments for Substance Use Disorders.
University of Illinois At Chicago
Identification of small molecule inhibitors against MMP-14 via High-Throughput screening.
University of Illinois at Chicago
Synthesis and structure-activity relationships of 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine analogues as potent, noncompetitive metabotropic glutamate receptor subtype 5 antagonists; search for cocaine medications.
University of Illinois At Chicago
Further structure-activity relationship studies of piperidine-based monoamine transporter inhibitors: effects of piperidine ring stereochemistry on potency. Identification of norepinephrine transporter selective ligands and broad-spectrum transporter inhibitors.
University of Illinois At Chicago
Synthesis and monoamine transporter affinity of 3-aryl substituted trop-2-enes.
University of Illinois At Chicago
Discovery of Anticancer Agents of Diverse Natural Origin.
University of Illinois At Chicago
Novel pyridyl ring C5 substituted analogues of epibatidine and 3-(1-methyl-2(S)-pyrrolidinylmethoxy)pyridine (A-84543) as highly selective agents for neuronal nicotinic acetylcholine receptors containing beta2 subunits.
University of Illinois At Chicago
Design and synthesis of a potent and selective peptidomimetic inhibitor of caspase-3.
University of Illinois At Chicago
The Flavonoid Baicalein Negatively Regulates Progesterone Target Genes in the Uterus
University of Illinois At Chicago
Synthesis of urea-based inhibitors as active site probes of glutamate carboxypeptidase II: efficacy as analgesic agents.
University of Illinois At Chicago
Tetrahydroquinoline-Capped Histone Deacetylase 6 Inhibitor SW-101 Ameliorates Pathological Phenotypes in a Charcot-Marie-Tooth Type 2A Mouse Model.
University of Illinois At Chicago
Isolation and Pharmacological Characterization of Six Opioidergic
University of Illinois At Chicago
A potent photoreactive general anesthetic with novel binding site selectivity for GABA
University of Illinois At Chicago
Design and Discovery of Functionally Selective Serotonin 2C (5-HT
University of Illinois At Chicago
Screening and Reverse-Engineering of Estrogen Receptor Ligands as Potent Pan-Filovirus Inhibitors.
University of Illinois At Chicago
Cyclooxygenase-inhibitory and antioxidant constituents of the aerial parts of Antirhea acutata.
University of Illinois At Chicago
Discovery and Structural Optimization of 4-(Aminomethyl)benzamides as Potent Entry Inhibitors of Ebola and Marburg Virus Infections.
University of Illinois At Chicago
Structural and in Vivo Characterization of Tubastatin A, a Widely Used Histone Deacetylase 6 Inhibitor.
University of Illinois At Chicago
Novel Pyrrolopyridone Bromodomain and Extra-Terminal Motif (BET) Inhibitors Effective in Endocrine-Resistant ER+ Breast Cancer with Acquired Resistance to Fulvestrant and Palbociclib.
University of Illinois At Chicago
Synthesis and Evaluation of Noncovalent Naphthalene-Based KEAP1-NRF2 Inhibitors.
University of Illinois At Chicago
Ca-asp bound X-ray structure and inhibition of Bacillus anthracis dihydroorotase (DHOase).
University of Illinois At Chicago
Protein Tyrosine Phosphatase 1B Inhibitory Iridoids from
University of Illinois At Chicago
Synthesis and opiate receptor binding properties of 17-methyl-6,7-dehydro-3,14-dihydroxy-4,5alpha-epoxy-6,7:4',5'-pyrimidin omorphinans.
University of Illinois At Chicago
Optimization of 4-Aminopiperidines as Inhibitors of Influenza A Viral Entry That Are Synergistic with Oseltamivir.
University of Illinois At Chicago
Identification and design of novel small molecule inhibitors against MERS-CoV papain-like protease via high-throughput screening and molecular modeling.
University of Illinois At Chicago
Design of fluorinated cyclopropane derivatives of 2-phenylcyclopropylmethylamine leading to identification of a selective serotonin 2C (5-HT
University of Illinois At Chicago
Design and Synthesis of Basic Selective Estrogen Receptor Degraders for Endocrine Therapy Resistant Breast Cancer.
University of Illinois At Chicago
Discovery of a New Isoxazole-3-hydroxamate-Based Histone Deacetylase 6 Inhibitor SS-208 with Antitumor Activity in Syngeneic Melanoma Mouse Models.
University of Illinois At Chicago
Lead Optimization of Benzoxazolone Carboxamides as Orally Bioavailable and CNS Penetrant Acid Ceramidase Inhibitors.
University of Illinois At Chicago
Caspase-Dependent Apoptosis in Prostate Cancer Cells and Zebrafish by Corchorusoside C from Streptocaulon juventas.
University of Illinois At Chicago
Non-electrophilic modulators of the canonical Keap1/Nrf2 pathway.
University of Illinois At Chicago
Identification of novel drug scaffolds for inhibition of SARS-CoV 3-Chymotrypsin-like protease using virtual and high-throughput screenings.
University of Illinois At Chicago
Characterization of maleimide-based glycogen synthase kinase-3 (GSK-3) inhibitors as stimulators of steroidogenesis.
University of Illinois At Chicago
Flavonoids as DNA topoisomerase antagonists and poisons: structure-activity relationships.
University of Illinois At Chicago
Synthesis and pharmacological evaluation of novel 9- and 10-substituted cytisine derivatives. Nicotinic ligands of enhanced subtype selectivity.
University of Illinois At Chicago
Pentacyclic triterpenes derived from Maprounea africana are potent inhibitors of HIV-1 reverse transcriptase.
University of Illinois At Chicago
The Berkeleylactones, Antibiotic Macrolides from Fungal Coculture.
University of Illinois At Chicago
2-Aminoadipic Acid-C(O)-Glutamate Based Prostate-Specific Membrane Antigen Ligands for Potential Use as Theranostics.
University of Illinois At Chicago
Discovery of small molecule inhibitors of adenovirus by disrupting E3-19K/HLA-A2 interactions.
University of Illinois At Chicago
Design, Synthesis, and Biological Evaluation of Tetrahydroisoquinoline-Based Histone Deacetylase 8 Selective Inhibitors.
University of Illinois At Chicago
Replacement of a Naphthalene Scaffold in Kelch-like ECH-Associated Protein 1 (KEAP1)/Nuclear Factor (Erythroid-derived 2)-like 2 (NRF2) Inhibitors.
University of Illinois At Chicago
Synthesis and pharmacological evaluation of neurosteroid photoaffinity ligands.
University of Illinois At Chicago
2-Arylidene Hydrazinecarbodithioates as Potent, Selective Inhibitors of Cystathionine γ-Lyase (CSE).
University of Illinois At Chicago
Synthesis and Pharmacological Evaluation of Selective Histone Deacetylase 6 Inhibitors in Melanoma Models.
University of Illinois At Chicago
JAK kinase inhibitor compounds for treatment of respiratory disease
Theravance Biopharma R&D Ip
Pharmaceutical compositions and their use for treatment of cancer and autoimmune diseases
Zhejiang Dtrm Biopharma
Molecular cloning and expression of a 5-hydroxytryptamine7 serotonin receptor subtype.
National Institute of Neurological Disorders and Stroke
Design, synthesis, and biological evaluation of hydroquinone derivatives as novel inhibitors of the sarco/endoplasmic reticulum calcium ATPase.
Northern Kentucky University
Potent 7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid-based macrocyclic inhibitors of hepatitis C virus NS3 protease.
Schering-Plough Research Institute
Structure-based design and synthesis of 2-benzylidene-benzofuran-3-ones as flavopiridol mimics.
Novartis Pharmaceuticals
2-Pyridinone derivatives: a new class of nonnucleoside, HIV-1-specific reverse transcriptase inhibitors.
Merck Sharp and Dohme Research Laboratories