67 articles for thisTarget
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Probing of primed and unprimed sites of calpains: Design, synthesis and evaluation of epoxysuccinyl-peptide derivatives as selective inhibitors.
E£Tv£S Lor£Nd University (Elte)
Design, synthesis, and optimization of novel epoxide incorporating peptidomimetics as selective calpain inhibitors.
University of Illinois College of Pharmacy
Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation.
University of Florida
Design and synthesis of calpain inhibitory 6-pyridone 2-carboxamide derivatives.
Kyung Hee University
Identification of 3-acetyl-2-aminoquinolin-4-one as a novel, nonpeptidic scaffold for specific calpain inhibitory activity.
Ewha Womans University
Design and synthesis of 4-aryl-4-oxobutanoic acid amides as calpain inhibitors.
Shenyang Pharmaceutical University
D-amino acid containing, high-affinity inhibitors of recombinant human calpain I.
Cephalon
Dipeptidyl aspartyl fluoromethylketones as potent caspase-3 inhibitors: SAR of the P2 amino acid.
Maxim Pharmaceuticals
1,2-Benzothiazine 1,1-dioxide alpha-ketoamide analogues as potent calpain I inhibitors.
Cephalon
Hydroxyoxazolidines as alpha-aminoacetaldehye equivalents: novel inhibitors of calpain.
Hoechst Marion Roussel
Molecular modeling: a search for a calpain inhibitor as a new treatment for cataractogenesis.
University of Canterbury
Synthesis of cinnamoyl ketoamides as hybrid structures of antioxidants and calpain inhibitors.
College of Pharmacy Kyung Hee University
Peptidyl alpha-ketoamides with nucleobases, methylpiperazine, and dimethylaminoalkyl substituents as calpain inhibitors.
Georgia Institute of Technology
Molecular design to enhance the penetration into the retina via ocular instillation.
Senju Pharmaceutical
Synthesis and calpain inhibitory activity of peptidomimetic compounds with constrained amino acids at the P2 position.
The University of Tennessee Health Science Center
NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family.
Johann Wolfgang Goethe University
N-acylbenzimidazoles as selective Acylators of the catalytic cystein of the coronavirus 3CL protease.
Univ. Lille
Design and synthesis of 4-quinolinone 2-carboxamides as calpain inhibitors.
Kyung Hee University
Discovery of Novel Nonpeptidic and Noncovalent Small Molecule 3CLpro Inhibitors as anti-SARS-CoV-2 Drug Candidate.
University of Chinese Academy of Sciences
Macrocyclic Oxindole Peptide Epoxyketones-A Comparative Study of Macrocyclic Inhibitors of the 20S Proteasome.
Whitman College
Synthesis, calpain inhibitory activity, and cytotoxicity of P2-substituted proline and thiaproline peptidyl aldehydes and peptidyl alpha-ketoamides.
The University of Tennessee Health Science Center
Exploration of orally available calpain inhibitors 2: peptidyl hemiacetal derivatives.
Senju Pharmaceutical
Expedited Approach toward the Rational Design of Noncovalent SARS-CoV-2 Main Protease Inhibitors.
The University of Arizona
The Alpha Keto Amide Moiety as a Privileged Motif in Medicinal Chemistry: Current Insights and Emerging Opportunities.
Niddk
Synthesis and biological evaluation of chromone carboxamides as calpain inhibitors.
Institute of Science & Technology
Dipeptidyl aspartyl fluoromethylketones as potent caspase inhibitors: peptidomimetic replacement of the P2 alpha-amino acid by a alpha-hydroxy acid.
Maxim Pharmaceuticals
Self-Masked Aldehyde Inhibitors: A Novel Strategy for Inhibiting Cysteine Proteases.
Texas A&M University
Benzoylalanine-derived ketoamides carrying vinylbenzyl amino residues: discovery of potent water-soluble calpain inhibitors with oral bioavailability.
Abbott
Structure-activity relationship study and drug profile of N-(4-fluorophenylsulfonyl)-L-valyl-L-leucinal (SJA6017) as a potent calpain inhibitor.
Senju Pharmaceutical
Neuroprotective effect of synthetic chalcone derivatives as competitive dual inhibitors against μ-calpain and cathepsin B through the downregulation of tau phosphorylation and insoluble Aβ peptide formation.
Ewha Womans University
Exploration of peptidyl hydrazones as water-soluble calpain inhibitors.
Senju Pharmaceutical
Discovery of phenyl alanine derived ketoamides carrying benzoyl residues as novel calpain inhibitors.
Abbott
1,2-Benzothiazine 1,1-dioxide P(2)-P(3) peptide mimetic aldehyde calpain I inhibitors.
Cephalon
Synthesis of a reported calpain inhibitor isolated from Streptomyces griseus.
The University of Tennessee Health Science Center
Potent peptide alpha-ketohydroxamate inhibitors of recombinant human calpain I.
Cephalon
Synthesis and antiproliferative activity of sulfonamide-based peptidomimetic calpain inhibitors.
University of Tennessee Health Science Center
Synthesis and biological evaluation of novel piperidine carboxamide derived calpain inhibitors.
Knoll
Discovery of ABT-957: 1-Benzyl-5-oxopyrrolidine-2-carboxamides as selective calpain inhibitors with enhanced metabolic stability.
Abbvie Deutschland
The synthesis of ketomethylene pseudopeptide analogues of dipeptide aldehyde inhibitors of calpain.
Hoechst Marion Roussel
Novel peptidyl alpha-keto amide inhibitors of calpains and other cysteine proteases.
Georgia Institute of Technology
Stereospecific synthesis of peptidyl alpha-keto amides as inhibitors of calpain.
Alkermes
C1 and N5 derivatives of cerpegin: synthesis of a new series based on structure-activity relationships to optimize their inhibitory effect on 20S proteasome.
Yerevan State University
Structure-based design of allosteric calpain-1 inhibitors populating a novel bioactivity space.
University of Cambridge
Discovery of potent calpain inhibitors based on the azolo-imidazolidenone scaffold.
Universidad De Alcal£
Mitigating the Metabolic Liability of Carbonyl Reduction: Novel Calpain Inhibitors with P1' Extension.
Abbvie Deutschland
Discovery of Novel and Highly Selective Inhibitors of Calpain for the Treatment of Alzheimer's Disease: 2-(3-Phenyl-1H-pyrazol-1-yl)-nicotinamides.
Abbvie Deutschland
Covalent Modifiers: A Chemical Perspective on the Reactivity ofα,β-Unsaturated Carbonyls with Thiols via Hetero-Michael Addition Reactions.
University of Pittsburgh
2,3-dihydro-isoindole-1-one derivative as BTK kinase suppressant, and pharmaceutical composition including same
Crystalgenomics
Imidazopyrimidine and imidazotriazine derivative, and pharmaceutical composition comprising the same
Sk Biopharmaceuticals
Imidazopyrazine compounds, preparation methods and uses thereof
Dongguan Zhenxing-Beite Medicine Technology
Macrocyclic insulin-degrading enzyme (IDE) inhibitors and uses thereof
President and Fellows of Harvard College