Compile Data Set for Download or QSAR
Report error Found 22 Enz. Inhib. hit(s) with all data for entry = 50000292
TargetExportin-1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50245464(CHEBI:52646 | LEPTOMYCIN B)
Affinity DataIC50: 1nMAssay Description:Inhibition of CRM1-mediated nucleocytoplasmic transport in human HeLa cells after 90 mins by immunofluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2019
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM86633(JNK-IN-8)
Affinity DataIC50: 1nMAssay Description:Inhibition of JNK3 (unknown origin) after 1 hr by FRET-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2019
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM86633(JNK-IN-8)
Affinity DataIC50: 1nMAssay Description:Inhibition of JNK2 (unknown origin) after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2019
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM86633(JNK-IN-8)
Affinity DataIC50: 1nMAssay Description:Inhibition of JNK1 (unknown origin) after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2019
Entry Details Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50245477(CHEMBL4073900)
Affinity DataIC50: 3nMAssay Description:Inhibition of human calpain 1 protease using Ac-LLY-AFC as substrate after 1 hr by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2019
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM259808(US9505766, CN-NHiPr (7) | US9505766, 74)
Affinity DataIC50: 5nMAssay Description:Inhibition of RSK2 in human MDA-MB-231 cells after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2019
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM259806(US9505766, CN-OtBu (5))
Affinity DataIC50: 7nMAssay Description:Inhibition of RSK2 in human MDA-MB-231 cells after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2019
Entry Details Article
PubMed
TargetExportin-1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50245476(CHEMBL4088268)
Affinity DataIC50: 10nMAssay Description:Inhibition of CRM1-mediated nucleocytoplasmic transport in human HeLa cells after 90 mins by immunofluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2019
Entry Details Article
PubMed
TargetPhospholipase A-2-activating protein(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50042034(CHEMBL1077979 | CHEBI:67559 | (5Z)-7-Oxozeaenol | ...)
Affinity DataIC50: 11nMAssay Description:Inhibition of TNFalpha-PLAP (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2019
Entry Details Article
PubMed
TargetExportin-1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50245473(CHEMBL4077955)
Affinity DataIC50: 25nMAssay Description:Inhibition of CRM1-mediated nucleocytoplasmic transport in human HeLa cells after 90 mins by immunofluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2019
Entry Details Article
PubMed
TargetPhospholipase A-2-activating protein(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50245461(CHEMBL4068569)
Affinity DataIC50: 36nMAssay Description:Inhibition of TNFalpha-PLAP (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2019
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM259804(US9505766, Me acrylate (2))
Affinity DataIC50: 250nMAssay Description:Inhibition of RSK2 in human MDA-MB-231 cells after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2019
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataIC50: 480nMAssay Description:Inhibition of EGF-stimulated wild type EGFR phosphorylation in human LoVo cells incubated for 2 hrs followed by EGF stimulation for 10 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2019
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM259803(US9505766, acrylonitrile (3))
Affinity DataIC50: 750nMAssay Description:Inhibition of RSK2 in human MDA-MB-231 cells after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2019
Entry Details Article
PubMed
TargetPhospholipase A-2-activating protein(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50245475(CHEMBL4103122)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of TNFalpha-PLAP (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2019
Entry Details Article
PubMed
TargetPhospholipase A-2-activating protein(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50245474(CHEMBL4078847)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of TNFalpha-PLAP (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2019
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50220832(CHEMBL8211 | N-ethylmaleimide)
Affinity DataIC50: 4.68E+4nMAssay Description:Inhibition of [3H]dopamine uptake at DAT in rat brain striatal synaptosomes by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2019
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50010912(CHEMBL721 | acrolein | acrylaldehyde)
Affinity DataIC50: 5.25E+4nMAssay Description:Inhibition of [3H]dopamine uptake at DAT in rat brain striatal synaptosomes by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2019
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50245462(CHEBI:48058 | CHEMBL1600824)
Affinity DataIC50: 3.31E+5nMAssay Description:Inhibition of [3H]dopamine uptake at DAT in rat brain striatal synaptosomes by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2019
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50226193(CHEBI:28619 | Acrylamide)
Affinity DataIC50: 4.38E+8nMAssay Description:Inhibition of [3H]dopamine uptake at DAT in rat brain striatal synaptosomes by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2019
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50245463(CHEBI:82482 | Acrylic Acid Methyl Ester)
Affinity DataIC50: 4.61E+8nMAssay Description:Inhibition of [3H]dopamine uptake at DAT in rat brain striatal synaptosomes by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2019
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM149404(US8975249, I-4 | CO-1686 | Rociletinib | AVL-301 |...)
Affinity DataKi:  303nMAssay Description:Binding affinity to recombinant human GST-tagged EGFR (668 to 1210 residues) cytoplasmic domain expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)