Compile Data Set for Download or QSAR
Report error Found 58 Enz. Inhib. hit(s) with all data for entry = 50017378
TargetPhospholipase A2, membrane associated(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50601469(CHEMBL5172164)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human group IIA phospholipase A2 preincubated with compound for 10 mins followed by enzyme addition and measured after 30 mins by PC/DO...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPhospholipase A2, membrane associated(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50053137((1-Aminooxalyl-3-biphenyl-2-ylmethyl-2-ethyl-indol...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human group IIA phospholipase A2 preincubated with compound for 10 mins followed by enzyme addition and measured after 30 mins by PC/DO...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPhospholipase A2, membrane associated(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50601472(CHEMBL5208632)
Affinity DataIC50: 5nMAssay Description:Inhibition of human group IIA phospholipase A2 preincubated with compound for 10 mins followed by enzyme addition and measured after 30 mins by PC/DO...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPhospholipase A2, membrane associated(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50055371((3-aminooxalyl-1-biphenyl-2-ylmethyl-2-methyl-1H-i...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human group IIA phospholipase A2 incubated for 1 hrs by scintillation counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPhospholipase A2, membrane associated(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50053137((1-Aminooxalyl-3-biphenyl-2-ylmethyl-2-ethyl-indol...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human group IIA phospholipase A2 incubated for 30 mins by automatic plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50601468(CHEMBL5179024)
Affinity DataIC50: 6.80nMAssay Description:Inhibition of MDM2 in human U-87 MG cells incubated for 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPhospholipase A2, membrane associated(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50601470(CHEMBL5177527)
Affinity DataIC50: 7nMAssay Description:Inhibition of human group IIA phospholipase A2 preincubated with compound for 10 mins followed by enzyme addition and measured after 30 mins by PC/DO...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPhospholipase A2, major isoenzyme(Pig)
Niddk

Curated by ChEMBL
LigandPNGBDBM50055384((3-Aminooxalyl-1-biphenyl-3-ylmethyl-2-methyl-1H-i...)
Affinity DataIC50: 7nMAssay Description:Inhibition of pig group IB phospholipase A2 incubated for 1 hrs by scintillation counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPhospholipase A2, membrane associated(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50601470(CHEMBL5177527)
Affinity DataIC50: 7nMAssay Description:Inhibition of human group IIA phospholipase A2 incubated for 30 mins by automatic plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPhospholipase A2, membrane associated(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50601469(CHEMBL5172164)
Affinity DataIC50: 8nMAssay Description:Inhibition of human group IIA phospholipase A2 incubated for 30 mins by automatic plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPhospholipase A2, membrane associated(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50055366(Varespladib sodium | (3-Aminooxalyl-1-benzyl-2-eth...)
Affinity DataIC50: 9nMAssay Description:Inhibition of human group IIA phospholipase A2 incubated for 1 hrs by scintillation counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPhospholipase A2, membrane associated(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50055384((3-Aminooxalyl-1-biphenyl-3-ylmethyl-2-methyl-1H-i...)
Affinity DataIC50: 9nMAssay Description:Inhibition of human group IIA phospholipase A2 incubated for 1 hrs by scintillation counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPhospholipase A2 group V(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50601469(CHEMBL5172164)
Affinity DataIC50: 10nMAssay Description:Inhibition of human group V phospholipase A2 expressed in Escherichia coli BL21(DE3) cells incubated for 10 to 20 mins cells by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetGroup IIE secretory phospholipase A2(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50601469(CHEMBL5172164)
Affinity DataIC50: 10nMAssay Description:Inhibition of human group IIE phospholipase A2 expressed in Escherichia coli BL21 cells incubated for 10 to 20 mins cells by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPhospholipase A2 group V(Mouse)
Niddk

Curated by ChEMBL
LigandPNGBDBM50601469(CHEMBL5172164)
Affinity DataIC50: 10nMAssay Description:Inhibition of mouse group V phospholipase A2 incubated for 10 to 20 mins cells by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetGroup IIE secretory phospholipase A2(Mouse)
Niddk

Curated by ChEMBL
LigandPNGBDBM50601469(CHEMBL5172164)
Affinity DataIC50: 10nMAssay Description:Inhibition of mouse group IIE phospholipase A2 incubated for 10 to 20 mins cells by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPhospholipase A2, membrane associated(Mouse)
Niddk

Curated by ChEMBL
LigandPNGBDBM50601469(CHEMBL5172164)
Affinity DataIC50: 10nMAssay Description:Inhibition of mouse group IIA phospholipase A2 incubated for 10 to 20 mins cells by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPhospholipase A2, membrane associated(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50601469(CHEMBL5172164)
Affinity DataIC50: 10nMAssay Description:Inhibition of human group IIA phospholipase A2 incubated for 10 to 20 mins cells by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetGroup IIC secretory phospholipase A2(Mouse)
Niddk

Curated by ChEMBL
LigandPNGBDBM50601469(CHEMBL5172164)
Affinity DataIC50: 10nMAssay Description:Inhibition of mouse group IIC phospholipase A2 incubated for 10 to 20 mins cells by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPhospholipase A2, membrane associated(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50055383(2-(3-(2-amino-2-oxoacetyl)-1-benzyl-2-methyl-1Hind...)
Affinity DataIC50: 11nMAssay Description:Inhibition of human group IIA phospholipase A2 incubated for 1 hrs by scintillation counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50601466(CHEMBL5172740)
Affinity DataIC50: 12nMAssay Description:Inhibition of MDM2 (unknown origin) by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPhospholipase A2, major isoenzyme(Pig)
Niddk

Curated by ChEMBL
LigandPNGBDBM50055383(2-(3-(2-amino-2-oxoacetyl)-1-benzyl-2-methyl-1Hind...)
Affinity DataIC50: 15nMAssay Description:Inhibition of pig group IB phospholipase A2 incubated for 1 hrs by scintillation counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPhospholipase A2, membrane associated(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50601472(CHEMBL5208632)
Affinity DataIC50: 30nMAssay Description:Inhibition of human group IIA phospholipase A2 incubated for 30 mins by automatic plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPhospholipase A2, major isoenzyme(Pig)
Niddk

Curated by ChEMBL
LigandPNGBDBM50055366(Varespladib sodium | (3-Aminooxalyl-1-benzyl-2-eth...)
Affinity DataIC50: 48nMAssay Description:Inhibition of pig group IB phospholipase A2 incubated for 1 hrs by scintillation counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPhospholipase A2, major isoenzyme(Pig)
Niddk

Curated by ChEMBL
LigandPNGBDBM50055371((3-aminooxalyl-1-biphenyl-2-ylmethyl-2-methyl-1H-i...)
Affinity DataIC50: 97nMAssay Description:Inhibition of pig group IB phospholipase A2 incubated for 1 hrs by scintillation counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPhospholipase A2(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50601469(CHEMBL5172164)
Affinity DataIC50: 100nMAssay Description:Inhibition of human group IB phospholipase A2 expressed in Escherichia coli BL21 cells incubated for 10 to 20 mins cells by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPhospholipase A2(Mouse)
Niddk

Curated by ChEMBL
LigandPNGBDBM50601469(CHEMBL5172164)
Affinity DataIC50: 100nMAssay Description:Inhibition of mouse group IB phospholipase A2 incubated for 10 to 20 mins cells by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetGroup 10 secretory phospholipase A2(Mouse)
Niddk

Curated by ChEMBL
LigandPNGBDBM50601469(CHEMBL5172164)
Affinity DataIC50: 100nMAssay Description:Inhibition of mouse group X phospholipase A2 incubated for 10 to 20 mins cells by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetGroup 10 secretory phospholipase A2(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50601469(CHEMBL5172164)
Affinity DataIC50: 100nMAssay Description:Inhibition of human group X phospholipase A2 incubated for 10 to 20 mins cells by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50601467(CHEMBL5169788)
Affinity DataIC50: 202nMAssay Description:Inhibition of MDM2 (unknown origin) by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPhospholipase A2(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50055366(Varespladib sodium | (3-Aminooxalyl-1-benzyl-2-eth...)
Affinity DataIC50: 228nMAssay Description:Inhibition of human group IB phospholipase A2 incubated for 1 hrs by scintillation counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPhospholipase A2(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50055371((3-aminooxalyl-1-biphenyl-2-ylmethyl-2-methyl-1H-i...)
Affinity DataIC50: 364nMAssay Description:Inhibition of human group IB phospholipase A2 incubated for 1 hrs by scintillation counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPhospholipase A2(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50055384((3-Aminooxalyl-1-biphenyl-3-ylmethyl-2-methyl-1H-i...)
Affinity DataIC50: 570nMAssay Description:Inhibition of human group IB phospholipase A2 incubated for 1 hrs by scintillation counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Niddk

Curated by ChEMBL
LigandPNGBDBM420295(med.21724, Compound 67 | alpha-ketoamide inhibitor...)
Affinity DataIC50: 670nMAssay Description:Inhibition of recombinant SARS-CoV-2 Main proteaseMore data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPhospholipase A2(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50055383(2-(3-(2-amino-2-oxoacetyl)-1-benzyl-2-methyl-1Hind...)
Affinity DataIC50: 761nMAssay Description:Inhibition of human group IB phospholipase A2 incubated for 1 hrs by scintillation counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPhospholipase A2, membrane associated(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50053170(4-(3-Aminooxalyl-1-benzyl-2-ethyl-indolizin-6-ylox...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human group IIA phospholipase A2 incubated for 30 mins by automatic plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Niddk

Curated by ChEMBL
LigandPNGBDBM50601463(CHEMBL5170500)
Affinity DataIC50: 2.39E+3nMAssay Description:Inhibition of SARS-Cov-2 Main proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPhospholipase A2(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50055737(1-BENZYL-5-METHOXY-2-METHYL-1H-INDOL-3-YL)-ACETIC ...)
Affinity DataIC50: 1.36E+4nMAssay Description:Inhibition of human non pancreatic secretory phospholipase A2 incubated for 30 mins by plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPhospholipase A2, membrane associated(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50601471(CHEMBL5179965)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of human group IIA phospholipase A2 incubated for 30 mins by automatic plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPhospholipase A2, membrane associated(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50053134((3-Benzyl-2-ethyl-1-methylaminooxalyl-indolizin-8-...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human group IIA phospholipase A2 incubated for 30 mins by automatic plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTranslocator protein(Bovine)
Niddk

Curated by ChEMBL
LigandPNGBDBM50019213(5-(2-chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benz...)
Affinity DataKi:  0.850nMAssay Description:Binding affinity to bovine brain membrane BzR assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTranslocator protein(Bovine)
Niddk

Curated by ChEMBL
LigandPNGBDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)
Affinity DataKi:  0.900nMAssay Description:Binding affinity to bovine brain membrane BzR assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetCathepsin K(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50601464(CHEMBL5195850)
Affinity DataKi:  1.80nMAssay Description:Inhibition of human Cathepsin K assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTranslocator protein(Rat)
Niddk

Curated by ChEMBL
LigandPNGBDBM50143225(N,N-Dibutyl-2-[5-chloro-2-(4-chloro-phenyl)-1H-ind...)
Affinity DataKi:  1.90nMAssay Description:Displacement of [3H]-PK11195 from rat kidney mitochondrial membrane TSPO receptor assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTranslocator protein(Rat)
Niddk

Curated by ChEMBL
LigandPNGBDBM50601465(CHEMBL5204536)
Affinity DataKi:  5.5nMAssay Description:Displacement of [3H]-PK11195 from rat kidney mitochondrial membrane TSPO receptor assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTranslocator protein(Rat)
Niddk

Curated by ChEMBL
LigandPNGBDBM50143238(2-[5-Chloro-2-(4-chloro-phenyl)-1H-indol-3-yl]-N,N...)
Affinity DataKi:  5.80nMAssay Description:Displacement of [3H]-PK11195 from rat kidney mitochondrial membrane TSPO receptor assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTranslocator protein(Rat)
Niddk

Curated by ChEMBL
LigandPNGBDBM22032(PK 11195 | PK11195 | RP 52028 | N-(butan-2-yl)-1-(...)
Affinity DataKi:  9.30nMAssay Description:Displacement of [3H]-PK11195 from rat kidney mitochondrial membrane TSPO receptor assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetCalpain-1 catalytic subunit(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50258312(CHEMBL4095528)
Affinity DataKi:  18nMAssay Description:Inhibition of Calpain I (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTranslocator protein(Rat)
Niddk

Curated by ChEMBL
LigandPNGBDBM22040(Ro5-4864 | 4' Cl-diazepam | 4 -chlorodiazepam ...)
Affinity DataKi:  23nMAssay Description:Binding affinity rat kidney mitochondrial membrane TSPO receptor assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetCathepsin B(Human)
Niddk

Curated by ChEMBL
LigandPNGBDBM50601464(CHEMBL5195850)
Affinity DataKi:  28nMAssay Description:Inhibition of human Cathepsin B assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
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