56 articles for thisTarget
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Synthesis of novel 1,2,4-triazine scaffold as FAK inhibitors with antitumor activity.
University of Paris
Synthesis and biological activity of CCK26-33-related analogues modified in position 31.
University of Paris
Guttiferone A Aggregates Modulate Silent Information Regulator 1 (SIRT1) Activity.
University of Paris
Design, synthesis, and evaluation of novel imidazo[1,2-a][1,3,5]triazines and their derivatives as focal adhesion kinase inhibitors with antitumor activity.
University of Paris
6-(Hetero)Arylpurine nucleotides as inhibitors of the oncogenic target DNPH1: synthesis, structural studies and cytotoxic activities.
University of Paris
Synthesis of novel diarylamino-1,3,5-triazine derivatives as FAK inhibitors with anti-angiogenic activity.
University of Paris
Potent inhibitors of CDK5 derived from roscovitine: synthesis, biological evaluation and molecular modelling.
University of Paris
Design and synthesis of novel bis-thiazolone derivatives as micromolar CDC25 phosphatase inhibitors: effect of dimerisation on phosphatase inhibition.
University of Paris
Novel naphthoquinone and quinolinedione inhibitors of CDC25 phosphatase activity with antiproliferative properties.
University of Paris
Long lasting antinociceptive properties of enkephalin degrading enzyme (NEP and APN) inhibitor prodrugs.
University of Paris
Phosphinic derivatives as new dual enkephalin-degrading enzyme inhibitors: synthesis, biological properties, and antinociceptive activities.
University of Paris
Metallopeptidase inhibitors of tetanus toxin: A combinatorial approach.
University of Paris
Investigation of subsite preferences in aminopeptidase A (EC 3.4.11.7) led to the design of the first highly potent and selective inhibitors of this enzyme.
University of Paris
Structure-based design of new constrained cyclic agonists of the cholecystokinin CCK-B receptor.
University of Paris
Synthesis and biological properties of new constrained CCK-B antagonists: discrimination of two affinity states of the CCK-B receptor on transfected CHO cells.
University of Paris
Optimal recognition of neutral endopeptidase and angiotensin-converting enzyme active sites by mercaptoacyldipeptides as a means to design potent dual inhibitors.
University of Paris
Design of orally active dual inhibitors of neutral endopeptidase and angiotensin-converting enzyme with long duration of action.
University of Paris
Investigation of the active site of aminopeptidase A using a series of new thiol-containing inhibitors.
University of Paris
New thiol inhibitors of neutral endopeptidase EC 3.4.24.11: synthesis and enzyme active-site recognition.
University of Paris
CCK-B agonist or antagonist activities of structurally hindered and peptidase-resistant Boc-CCK4 derivatives.
University of Paris
Potent and systemically active aminopeptidase N inhibitors designed from active-site investigation.
University of Paris
Investigation of the structural parameters involved in the mu and delta opioid receptor discrimination of linear enkephalin-related peptides.
University of Paris
Synthesis and biological characterisation of [3H]BBL454, a new CCK2 selective radiolabelled agonist displaying original pharmacological properties.
University of Paris
Design of the first highly potent and selective aminopeptidase N (EC 3.4.11.2) inhibitor.
University of Paris
Synthesis and biological evaluation of a diazepanone-based library of liposidomycins analogs as MraY inhibitors.
University of Paris
Bacterial transferase MraY inhibitors: synthesis and biological evaluation.
University of Paris
Biochemical and structural analysis of the binding determinants of a vascular endothelial growth factor receptor peptidic antagonist.
University of Paris
5-Substituted [1]pyrindine derivatives with antiproliferative activity.
University of Paris
Insights from structure-activity relationships and the binding mode of peptidic α-ketoamide inhibitors of the malaria drug target subtilisin-like SUB1.
University of Paris
Design and Validation of the First Family of Photo-Activatable Ligands for Melatonin Receptors.
University of Paris
Synthesis of indole inhibitors of silent information regulator 1 (SIRT1), and their evaluation as cytotoxic agents.
University of Paris
N-[2-(Indan-1-yl)-3-mercapto-propionyl] amino acids as highly potent inhibitors of the three vasopeptidases (NEP, ACE, ECE): In vitro and In vivo activities.
University of Paris
Design, Synthesis, and Biological Evaluation of Covalent Inhibitors of Focal Adhesion Kinase (FAK) against Human Malignant Glioblastoma.
University of Paris
Discovery, SAR study and ADME properties of methyl 4-amino-3-cyano-1-(2-benzyloxyphenyl)-1
University of Paris
Amino Acids Bearing Aromatic or Heteroaromatic Substituents as a New Class of Ligands for the Lysosomal Sialic Acid Transporter Sialin.
University of Paris
Replacement of glycine with dicarbonyl and related moieties in analogues of the C-terminal pentapeptide of cholecystokinin: CCK(2) agonists displaying a novel binding mode.
University of Paris
Inhibition of the ras-dependent mitogenic pathway by phosphopeptide prodrugs with antiproliferative properties.
University of Paris
Small peptides containing phosphotyrosine and adjacent alphaMe-phosphotyrosine or its mimetics as highly potent inhibitors of Grb2 SH2 domain.
University of Paris
Novel constrained CCK-B dipeptoid antagonists derived from pipecolic acid.
University of Paris
Exploration of neutral endopeptidase active site by a series of new thiol-containing inhibitors.
University of Paris
Cholecystokinin peptidomimetics as selective CCK-B antagonists: design, synthesis, and in vitro and in vivo biochemical properties.
University of Paris
Synthesis and structure-activity studies of a series of [(hydroxybenzyl)amino]salicylates as inhibitors of EGF receptor-associated tyrosine kinase activity.
University of Paris
New dual inhibitors of neutral endopeptidase and angiotensin-converting enzyme: rational design, bioavailability, and pharmacological responses in experimental hypertension.
University of Paris
Structure-activity relationships in a series of 5-[(2,5-dihydroxybenzyl)amino]salicylate inhibitors of EGF-receptor-associated tyrosine kinase: importance of additional hydrophobic aromatic interactions.
University of Paris
Differential inhibition of aminopeptidase A and aminopeptidase N by new beta-amino thiols.
University of Paris
Inhibition of the EGF-stimulated cellular proliferation of ER 22 cells by hydroxybiphenyl derivatives.
University of Paris
Melatonergic properties of the (+)- and (-)-enantiomers of N-(4-methoxy-2,3-dihydro-1H-phenalen-2-yl)amide derivatives.
University of Paris
Three-dimensional quantitative structure-activity relationship of melatonin receptor ligands: a comparative molecular field analysis study.
University of Paris
New kelatorphan-related inhibitors of enkephalin metabolism: improved antinociceptive properties.
University of Paris
Synthesis and binding affinities of cyclic and related linear analogues of CCK8 selective for central receptors.
University of Paris
Full agonists of CCK8 containing a nonhydrolyzable sulfated tyrosine residue.
University of Paris
Exploration of the imidazo[1,2-b]pyridazine scaffold as a protein kinase inhibitor.
University of Paris
Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at Dual sites.
University of Paris