68 articles for thisTarget
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Article Title
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II. Discovery of a novel series of CXCR3 antagonists with a beta amino acid core.
Sanofi
I. Discovery of a novel series of CXCR3 antagonists. Multiparametric optimization of N,N-disubstituted benzylamines.
Sanofi
Preparation and optimization of new 4-(2-(indolin-1-yl)-2-oxoethyl)-2-morpholinothiazole-5-carboxylic acid and amide derivatives as potent and selective PI3Kß inhibitors.
Sanofi
Discovery and optimization of pyrimidone indoline amide PI3Kß inhibitors for the treatment of phosphatase and tensin homologue (PTEN)-deficient cancers.
Sanofi
Design of substituted imidazolidinylpiperidinylbenzoic acids as chemokine receptor 5 antagonists: potent inhibitors of R5 HIV-1 replication.
Sanofi
Preparation and optimization of new 4-(morpholin-4-yl)-(6-oxo-1,6-dihydropyrimidin-2-yl)amide derivatives as PI3Kß inhibitors.
Sanofi
Discovery and Optimization of a Series of Benzofuran Selective ERAP1 Inhibitors: Biochemical and
Sanofi
Discovery of SARxxxx92, a pan-PIM kinase inhibitor, efficacious in a KG1 tumor model.
Sanofi
Discovery of N-substituted 7-azaindoles as Pan-PIM kinases inhibitors - Lead optimization - Part III.
Sanofi
Development of a novel NURR1/NOT agonist from hit to lead and candidate for the potential treatment of Parkinson's disease.
Sanofi
The use of virtual screening and differential scanning fluorimetry for the rapid identification of fragments active against MEK1.
Sanofi
IMIDAZO[1,2-A]PYRIDINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE
Hoffmann-La Roche
5-chloro-2-difluoromethoxyphenyl pyrazolopyrimidine compounds, compositions and methods of use thereof
Genentech
Amino-oxazine and amino-dihydrothiazine compounds as beta-secretase modulators and methods of use
Amgen
Structure-based design of benzo[e]isoindole-1,3-dione derivatives as selective GSK-3ß inhibitors to activate Wnt/ß-catenin pathway.
Peking University
Substituted pyrido[2,3-d]pyrimidin-7(8H)-ones and therapeutic uses thereof
Temple University
Substituted dihydropyrazolones and use thereof as HIF-prolyl-4-hydroxylase inhibitors
Bayer Intellectual Property
Synthesis of tetramic and tetronic acids as beta-secretase inhibitors.
Darmstadt Technical University
Uridine-based inhibitors as new leads for antibiotics targeting Escherichia coli LpxC.
Duke University
Mechanistic analysis of trehalose synthase from Mycobacterium smegmatis.
University of British Columbia
Characterization of the interaction of indiplon, a novel pyrazolopyrimidine sedative-hypnotic, with the GABAA receptor.
Neurocrine Biosciences
Milnacipran: a comparative analysis of human monoamine uptake and transporter binding affinity.
Emory University
SSR240600 [(R)-2-(1-[2-[4-[2-[3,5-bis(trifluoromethyl)phenyl]acetyl]-2-(3,4-dichlorophenyl)-2-morpholinyl]ethyl]- 4-piperidinyl)-2-methylpropanamide], a centrally active nonpeptide antagonist of the tachykinin neurokinin-1 receptor: I. biochemical and pharmacological characterization.
Sanofi-SynthÉLabo Recherche
Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors.
Eli Lilly
Evidence for a new G protein-coupled cannabinoid receptor in mouse brain.
Virginia Commonwealth University
Tyrosinase inhibition: conformational analysis based studies on molecular dynamics calculations of bipiperidine based inhibitors.
University of Karachi
Agonist-directed trafficking of porcine alpha(2A)-adrenergic receptor signaling in Chinese hamster ovary cells: l-isoproterenol selectively activates G(s).
University of Michigan
Evaluation of indole esters as inhibitors of p60(c-Src) receptor tyrosine kinase and investigation of the inhibition using receptor docking studies.
Kobe Gakuin University
OPC-41061, a highly potent human vasopressin V2-receptor antagonist: pharmacological profile and aquaretic effect by single and multiple oral dosing in rats.
Second Tokushima Institute of New Drug Research
Affinities of venlafaxine and various reuptake inhibitors for the serotonin and norepinephrine transporters.
Mcgill University
Cyclooxygenase-1 and cyclooxygenase-2 selectivity of widely used nonsteroidal anti-inflammatory drugs.
Dallas Department of Veterans Affairs Medical Center
Characterisation of the specific binding of the histamine H3 receptor antagonist radioligand [3H]GR168320.
Glaxo Research & Development
Unique binding characteristics of antipsychotic agents interacting with human dopamine D2A, D2B, and D3 receptors.
Astra Arcus
Characterization and distribution of binding sites for a new neurotensin receptor antagonist ligand, [3H]SR 48692, in the guinea pig brain.
Hospital Saint-Antoine
Characterization of (+/-)(-)[3H]epibatidine binding to nicotinic cholinergic receptors in rat and human brain.
Georgetown University
Characterization of alpha-2 adrenergic receptors in the OK cell, an opossum kidney cell line.
University of Missouri
Neurochemical profile of Lu 19-005, a potent inhibitor of uptake of dopamine, noradrenaline, and serotonin.
Lundbeck Ais
Characterization of kappa 1 and kappa 2 opioid binding sites in frog (Rana esculenta) brain membrane preparation.
Biological Research Center of Hungarian Academy of Sciences
Di-, tri- and tetra-5'-O-phosphorothioadenosyl substituted polyols as inhibitors of Fhit: Importance of the alpha-beta bridging oxygen and beta phosphorus replacement.
Kimmel Cancer Center
Development of small molecule inhibitors and probes of human SUMO deconjugating proteases.
Stanford University
Differential binding of inhibitors to active and inactive CDK2 provides insights for drug design.
Cyclacel
Aminoglycosides modified by resistance enzymes display diminished binding to the bacterial ribosomal aminoacyl-tRNA site.
Wayne State University