100 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
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Article Title
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Systematic Study of Effects of Structural Modifications on the Aqueous Solubility of Drug-like Molecules.
Yale University
Synergistic potentiation of (-)-lomaiviticin A cytotoxicity by the ATR inhibitor VE-821.
Yale University
Irregularities in enzyme assays: The case of macrophage migration inhibitory factor.
Yale University
Potent Inhibitors Active against HIV Reverse Transcriptase with K101P, a Mutation Conferring Rilpivirine Resistance.
Yale University
Synthesis of benzopentathiepin analogs and their evaluation as inhibitors of the phosphatase STEP.
Yale University
Structural studies provide clues for analog design of specific inhibitors of Cryptosporidium hominis thymidylate synthase-dihydrofolate reductase.
Yale University
Substrate-based fragment identification for the development of selective, nonpeptidic inhibitors of striatal-enriched protein tyrosine phosphatase.
Yale University
Increased anti-P-glycoprotein activity of baicalein by alkylation on the A ring.
Yale University
Virtual screening and optimization yield low-nanomolar inhibitors of the tautomerase activity of Plasmodium falciparum macrophage migration inhibitory factor.
Yale University
Design of a hypoxia-activated prodrug inhibitor of O6-alkylguanine-DNA alkyltransferase.
Yale University
Novel non-active site inhibitor of Cryptosporidium hominis TS-DHFR identified by a virtual screen.
Yale University
Targeted intracellular protein degradation induced by a small molecule: En route to chemical proteomics.
Yale University
Alternative chemical modifications reverse the binding orientation of a pharmacophore scaffold in the active site of macrophage migration inhibitory factor.
Yale University
Synthesis and monoamine transporter affinity of new 2beta-carbomethoxy-3beta-[4-(substituted thiophenyl)]phenyltropanes: discovery of a selective SERT antagonist with picomolar potency.
Yale University
General model for estimation of the inhibition of protein kinases using Monte Carlo simulations.
Yale University
Estimation of binding affinities for selective thrombin inhibitors via Monte Carlo simulations.
Yale University
Binding affinities for sulfonamide inhibitors with human thrombin using Monte Carlo simulations with a linear response method.
Yale University
Synthesis and anticancer and antiviral activities of various 2'- and 3'-methylidene-substituted nucleoside analogues and crystal structure of 2'-deoxy-2'-methylidenecytidine hydrochloride.
Yale University
Antiviral drug design: computational analyses of the effects of the L100I mutation for HIV-RT on the binding of NNRTIs.
Yale University
Computational binding studies of human pp60c-src SH2 domain with a series of nonpeptide, phosphophenyl-containing ligands.
Yale University
Cyclopentadienyltricarbonylrheniumbenzazepines: synthesis and binding affinity.
Yale University
Benzisothiazolones as modulators of macrophage migration inhibitory factor.
Yale University
Structure-based design and synthesis of potent, ethylenediamine-based, mammalian farnesyltransferase inhibitors as anticancer agents.
Yale University
Optimization of N-benzyl-benzoxazol-2-ones as receptor antagonists of macrophage migration inhibitory factor (MIF).
Yale University
Surveying polypeptide and protein domain conformation and association with FlAsH and ReAsH.
Yale University
An approach to the site-selective diversification of apoptolidin A with peptide-based catalysts.
Yale University
Discovery of novel fibroblast growth factor receptor 1 kinase inhibitors by structure-based virtual screening.
Yale University
Discovery of human macrophage migration inhibitory factor (MIF)-CD74 antagonists via virtual screening.
Yale University
Ibogaine, a noncompetitive inhibitor of serotonin transport, acts by stabilizing the cytoplasm-facing state of the transporter.
Yale University
Covalent and noncovalent strategies for targeting Lys102 in HIV-1 reverse transcriptase.
Yale University
Natural quinazolinones: From a treasure house to promising anticancer leads.
Yale University
Structure-activity studies of phenanthroindolizidine alkaloids as potential antitumor agents.
Yale University
Defining the structure-activity relationship for a novel class of allosteric MKP5 inhibitors.
Yale University
Modifications of the GSK3beta substrate sequence to produce substrate-mimetic inhibitors of Akt as potential anti-cancer therapeutics.
Yale University
Design, synthesis, and biological testing of biphenylmethyloxazole inhibitors targeting HIV-1 reverse transcriptase.
Yale University
Synthesis and monoamine transporter affinity of 2beta-carbomethoxy-3beta-(4'-p-substituted phenyl)-piperidine analogs of cocaine.
Yale University
Synthesis and monoamine transporter affinity of new 2beta-carbomethoxy-3beta-[aryl or heteroaryl]phenyltropanes.
Yale University
Insights on JAK2 Modulation by Potent, Selective, and Cell-Permeable Pseudokinase-Domain Ligands.
Yale University
Conversion of a False Virtual Screen Hit into Selective JAK2 JH2 Domain Binders Using Convergent Design Strategies.
Yale University
Functionalization at position 3 of the phenyl ring of the potent mGluR5 noncompetitive antagonists MPEP.
Yale University
Terephthalamide derivatives as mimetics of the helical region of Bak peptide target Bcl-xL protein.
Yale University
Design and synthesis of peptidomimetic protein farnesyltransferase inhibitors as anti-Trypanosoma brucei agents.
Yale University
Analyses of activity for factor Xa inhibitors based on Monte Carlo simulations.
Yale University
Synthesis and affinity of a possible byproduct of electrophilic radiolabeling of [123I]IBZM.
Yale University
Hydroxamate-Based Selective Macrophage Elastase (MMP-12) Inhibitors and Radiotracers for Molecular Imaging.
Yale University
Synthesis, receptor potency, and selectivity of halogenated diphenylpiperidines as serotonin 5-HT2A ligands for PET or SPECT brain imaging.
Yale University
Covalent Inhibition of Wild-Type HIV-1 Reverse Transcriptase Using a Fluorosulfate Warhead.
Yale University
Estimation of binding affinities for celecoxib analogues with COX-2 via Monte Carlo-extended linear response.
Yale University
Design and synthesis of potent nonpeptidic farnesyltransferase inhibitors based on a terphenyl scaffold.
Yale University
Peptidomimetic inhibitors of protein farnesyltransferase show potent antimalarial activity.
Yale University
Estimation of binding affinities for HEPT and nevirapine analogues with HIV-1 reverse transcriptase via Monte Carlo simulations.
Yale University
Design, synthesis and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK degraders with improved pharmacokinetic properties.
Yale University
Synthesis and monoamine transporter affinity of 2beta-carbomethoxy-3beta-(2''-, 3''- or 4''-substituted) biphenyltropanes.
Yale University
Cellular Activity of New Small Molecule Protein Arginine Deiminase 3 (PAD3) Inhibitors.
Yale University
Structure activity relationship towards design of cryptosporidium specific thymidylate synthase inhibitors.
Yale University
Molecular and cellular studies evaluating a potent 2-cyanoindolizine catechol diether NNRTI targeting wildtype and Y181C mutant HIV-1 reverse transcriptase.
Yale University
Potent, highly selective, and non-thiol inhibitors of protein geranylgeranyltransferase-I.
Yale University
Selective Janus Kinase 2 (JAK2) Pseudokinase Ligands with a Diaminotriazole Core.
Yale University
Investigations of neurotrophic inhibitors of FK506 binding protein via Monte Carlo simulations.
Yale University
Design, Conformation, and Crystallography of 2-Naphthyl Phenyl Ethers as Potent Anti-HIV Agents.
Yale University
Synthesis and biological activity of 3- and 5-amino derivatives of pyridine-2-carboxaldehyde thiosemicarbazone.
Yale University
Exploring novel strategies for AIDS protozoal pathogens: α-helix mimetics targeting a key allosteric protein-protein interaction in
Yale University
Virtual screening reveals allosteric inhibitors of the Toxoplasma gondii thymidylate synthase-dihydrofolate reductase.
Yale University
Design, Synthesis, and Antiviral Evaluation of Chimeric Inhibitors of HIV Reverse Transcriptase.
Yale University
Bifunctional inhibition of human immunodeficiency virus type 1 reverse transcriptase: mechanism and proof-of-concept as a novel therapeutic design strategy.
Yale University
Pre-steady state kinetic analysis of cyclobutyl derivatives of 2'-deoxyadenosine 5'-triphosphate as inhibitors of HIV-1 reverse transcriptase.
Yale University
Impact of novel human immunodeficiency virus type 1 reverse transcriptase mutations P119S and T165A on 4'-ethynylthymidine analog resistance profile.
Yale University
Mechanism of inhibition of human immunodeficiency virus type 1 reverse transcriptase by a stavudine analogue, 4'-ethynyl stavudine triphosphate.
Yale University
A novel class of meso-tetrakis-porphyrin derivatives exhibits potent activities against hepatitis C virus genotype 1b replicons in vitro.
Yale University
NMR-Based Investigation of Hydrogen Bonding in a Dihydroanthracen-1(4 H)one from Rubia philippinensis and Its Soluble Epoxide Hydrolase Inhibitory Potential.
Yale University
Synthesis and Biological Evaluation of an Indazole-Based Selective Protein Arginine Deiminase 4 (PAD4) Inhibitor.
Yale University
Advances and Insights for Small Molecule Inhibition of Macrophage Migration Inhibitory Factor.
Yale University
Unique arginine array improves cytosolic localization of hydrocarbon-stapled peptides.
Yale University
Adding a Hydrogen Bond May Not Help: Naphthyridinone vs Quinoline Inhibitors of Macrophage Migration Inhibitory Factor.
Yale University
X-ray Characterization and Structure-Based Optimization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors.
Yale University
Identification and Characterization of JAK2 Pseudokinase Domain Small Molecule Binders.
Yale University
JAK2 JH2 Fluorescence Polarization Assay and Crystal Structures for Complexes with Three Small Molecules.
Yale University
INHIBITORS OF THE ONCOGENIC SHP2 PHOSPHATASE AND USES THEREOF
Sanford Burnham Prebys Medical Discovery Institute
A NEW MOLECULAR SCAFFOLD FOR TARGETING HRPN13
Department of Health And Human Service
Toll-like receptor 7 (TLR7) agonists having a pyridine or pyrazine moiety, conjugates thereof, and methods and uses therefor
Bristol-Myers Squibb
Iminothiadiazepane dioxide compounds as BACE inhibitors, compositions, and their use
Merck Sharp & Dohme
3-aminocycloalkyl compounds as RORgammaT inhibitors and uses thereof
Merck Sharp & Dohme
Substituted quinazoline compounds and uses thereof for modulating glucocerebrosidase activity
Northwestern University
4-(ortho)-fluorophenyl-5-fluoropyrimidin-2-yl amines containing a sulfoximine group
Bayer Pharma Aktiengesellschaft