BDBM50277548 CHEMBL4173394

SMILES CCOc1ccc(Nc2ccc(cc2)C(=C2\C=C/C(/C=C2C)=[N+](/CC)Cc2cccc(c2)S([O-])(=O)=O)\c2ccc(cc2C)N(CC)Cc2cccc(c2)S([O-])(=O)=O)cc1

InChI Key InChIKey=YVNQAIFQFWTPLQ-UHFFFAOYSA-M

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50277548   

TargetP2X purinoceptor 7(Human)
Instituto Oswaldo Cruz

Curated by ChEMBL
LigandPNGBDBM50277548(CHEMBL4173394)
Affinity DataIC50: 536nMAssay Description:Antagonist activity at human P2X7R expressed in HEK293 cells assessed as inhibition of ATP-induced ethidium iodide uptake preincubated for 10 mins fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Mouse)
Instituto Oswaldo Cruz

Curated by ChEMBL
LigandPNGBDBM50277548(CHEMBL4173394)
Affinity DataIC50: 1.52E+4nMAssay Description:Antagonist activity at P2X7R in Swiss Webster mouse peritoneal macrophages assessed as inhibition of ATP-induced propidium iodide uptake preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetAlpha-synuclein(Human)
National Institute of Immunology

Curated by ChEMBL
LigandPNGBDBM50277548(CHEMBL4173394)
Affinity DataIC50: 5.40E+3nMAssay Description:Inhibition of wild type alpha-synuclein (unknown origin) aggregation expressed in Escherichia coli BL21 after 30 days by thioflavin T staining-based ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Mouse)
Instituto Oswaldo Cruz

Curated by ChEMBL
LigandPNGBDBM50277548(CHEMBL4173394)
Affinity DataIC50: 343nMAssay Description:Antagonist activity at P2X7 receptor in Swiss mouse peritoneal macrophages assessed as inhibition of ATP-induced propidium iodide uptake after 25 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Instituto Oswaldo Cruz

Curated by ChEMBL
LigandPNGBDBM50277548(CHEMBL4173394)
Affinity DataIC50: 552nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of ATP-induced ethidium iodide uptake preincubated for 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Mouse)
Instituto Oswaldo Cruz

Curated by ChEMBL
LigandPNGBDBM50277548(CHEMBL4173394)
Affinity DataIC50: 407nMAssay Description:Antagonist activity at P2X7 receptor in Swiss mouse peritoneal macrophages assessed as inhibition of BzATP-induced current at holding potential of -6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Mouse)
Instituto Oswaldo Cruz

Curated by ChEMBL
LigandPNGBDBM50277548(CHEMBL4173394)
Affinity DataIC50: 109nMAssay Description:Antagonist activity at P2X7 receptor in Swiss mouse peritoneal macrophages assessed as inhibition of ATP-induced current at holding potential of -60 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Mouse)
Instituto Oswaldo Cruz

Curated by ChEMBL
LigandPNGBDBM50277548(CHEMBL4173394)
Affinity DataIC50: 432nMAssay Description:Antagonist activity at P2X7 receptor in Swiss mouse peritoneal macrophages assessed as inhibition of BzATP-induced ethidium iodide uptake after 30 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Instituto Oswaldo Cruz

Curated by ChEMBL
LigandPNGBDBM50277548(CHEMBL4173394)
Affinity DataIC50: 1.37E+3nMAssay Description:Antagonist activity at human P2X7R expressed in HEK293 cells assessed as inhibition of ATP-induced ethidium iodide uptake preincubated for 5 mins fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed