48 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
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Article Title
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Design and synthesis of a new series of 3,5-disubstituted isoxazoles active against Trypanosoma cruzi and Leishmania amazonensis.
Federal University of Santa Catarina
Inhibitory effect of phenothiazine- and phenoxazine-derived chloroacetamides on Leishmania major growth and Trypanosoma brucei trypanothione reductase.
University of Wuerzburg
Applications of Fluorine in Medicinal Chemistry.
Bristol-Myers Squibb Research and Development
Dibenzosuberyl substituted polyamines and analogs of clomipramine as effective inhibitors of trypanothione reductase; molecular docking, and assessment of trypanocidal activities.
Canisius College
Synthesis and evaluation of the antiparasitic activity of bis-(arylmethylidene) cycloalkanones.
Universidade Federal De Minas Gerais
High-throughput screening affords novel and selective trypanothione reductase inhibitors with anti-trypanosomal activity.
Harvard Medical School
Inhibitors of Trypanosoma cruzi trypanothione reductase revealed by virtual screening and parallel synthesis.
Universit£T Heidelberg
Use of an additional hydrophobic binding site, the Z site, in the rational drug design of a new class of stronger trypanothione reductase inhibitor, quaternary alkylammonium phenothiazines.
University of Manchester
Optimising inhibitors of trypanothione reductase using solid-phase chemistry.
University of Southamton
Investigation of trypanothione reductase inhibitory activity by 1,3,4-thiadiazolium-2-aminide derivatives and molecular docking studies.
Instituto Oswaldo Cruz
Dihydroquinazolines as a novel class of Trypanosoma brucei trypanothione reductase inhibitors: discovery, synthesis, and characterization of their binding mode by protein crystallography.
University of Dundee
A fast virtual screening approach to identify structurally diverse inhibitors of trypanothione reductase.
University of Siena
Trypanothione reductase high-throughput screening campaign identifies novel classes of inhibitors with antiparasitic activity.
Monash University (Parkville Campus)
Discovery of novel and potent benzhydryl-tropane trypanocides highly selective for Trypanosoma cruzi.
Institute of Medical Research
Neglected tropical diseases: multi-target-directed ligands in the search for novel lead candidates against Trypanosoma and Leishmania.
University of Bologna
Privileged structure-guided synthesis of quinazoline derivatives as inhibitors of trypanothione reductase.
Alma Mater Studiorum-Bologna University
Novel polyamine derivatives as potent competitive inhibitors of Trypanosoma cruzi trypanothione reductase
TBA
The use of natural product scaffolds as leads in the search for trypanothione reductase inhibitors.
Pontificia Universidad Catolica Del Peru
Fragment Merging, Growing, and Linking Identify New Trypanothione Reductase Inhibitors for Leishmaniasis.
Sapienza University of Rome
Identification of 1,2,3-triazolium salt-based inhibitors of Leishmania infantum trypanothione disulfide reductase with enhanced antileishmanial potency in cellulo and increased selectivity.
Universidad De Alcal£
Evolution in non-peptide α-helix mimetics on the road to effective protein-protein interaction modulators.
IQM-CSIC
Novel alkylpolyaminoguanidines and alkylpolyaminobiguanides with potent antitrypanosomal activity.
Wayne State University
Antitrypanosomal, antileishmanial, and antimalarial activities of quaternary arylalkylammonium 2-amino-4-chlorophenyl phenyl sulfides, a new class of trypanothione reductase inhibitor, and of N-acyl derivatives of 2-amino-4-chlorophenyl phenyl sulfide.
University of Manchester
Irreversible inactivation of trypanothione reductase by unsaturated Mannich bases: a divinyl ketone as key intermediate.
Biochemie-Zentrum Der UniversitäT Heidelberg
Pyridazino-pyrrolo-quinoxalinium salts as highly potent and selective leishmanicidal agents targeting trypanothione reductase.
Universidad De Alcal£
Antitrypanosomal activities and cytotoxicity of 5-nitro-2-furancarbohydrazides.
Université
Antiprotozoal and cytotoxicity evaluation of sulfonamide and urea analogues of quinacrine.
University of Cape Town
Polyamines with N-(3-phenylpropyl) substituents are effective competitive inhibitors of trypanothione reductase and trypanocidal agents.
Indiana State University
2- and 3-substituted 1,4-naphthoquinone derivatives as subversive substrates of trypanothione reductase and lipoamide dehydrogenase from Trypanosoma cruzi: synthesis and correlation between redox cycling activities and in vitro cytotoxicity.
Umr 8525 Cnrs - Université
Parallel synthesis of a library of 1,4-naphthoquinones and automated screening of potential inhibitors of trypanothione reductase from Trypanosoma cruzi.
Université
Inhibition of Trypanosoma cruzi trypanothione reductase by acridines: kinetic studies and structure-activity relationships.
Heidelberg University
Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design.
Bristol-Myers Squibb
Structure-activity relationships in 2-aminodiphenylsulfides against trypanothione reductase from Trypanosoma cruzi.
Ura Cnrs 1309
Phenothiazine inhibitors of trypanothione reductase as potential antitrypanosomal and antileishmanial drugs.
University of Manchester
Conjugation of quinones with natural polyamines: toward an expanded antitrypanosomatid profile.
University of Bologna
Synthesis and antikinetoplastid evaluation of bis(benzyl)spermidine derivatives.
Paris-Saclay University
Trypanothione reductase inhibition and anti-leishmanial activity of all-hydrocarbon stapled α-helical peptides with improved proteolytic stability.
Instituto De Qu£Mica M£Dica (Iqm-Csic)
Synthesis and 2D-QSAR studies of neolignan-based diaryl-tetrahydrofuran and -furan analogues with remarkable activity against Trypanosoma cruzi and assessment of the trypanothione reductase activity.
University of S£O Paulo
Improved proteolytic stability and potent activity against Leishmania infantum trypanothione reductase of α/β-peptide foldamers conjugated to cell-penetrating peptides.
Universidad De Alcal£
Crassiflorone derivatives that inhibit Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase (TbGAPDH) and Trypanosoma cruzi trypanothione reductase (TcTR) and display trypanocidal activity.
University of Bologna
Bistacrines as potential antitrypanosomal agents.
Julius-Maximilians-University of W£Rzburg
First example of peptides targeting the dimer interface of Leishmania infantum trypanothione reductase with potent in vitro antileishmanial activity
Instituto De Qu£Mica M£Dica (Iqm-Csic)
Rational design of nitrofuran derivatives: Synthesis and valuation as inhibitors of Trypanosoma cruzi trypanothione reductase.
Universidad Nacional Del Litoral
Heterocyclic modulators of lipid synthesis for use against cancer and viral infections
3-V Biosciences