66 articles for thisTarget
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Biosynthetic approaches to creating bioactive fungal metabolites: Pathway engineering and activation of secondary metabolism.
Riken Csrs
Functional 1,3a,6a-triazapentalene scaffold: Design of fluorescent probes for kinesin spindle protein (KSP).
University of Shizuoka
Structure-Guided Design of Novel l-Cysteine Derivatives as Potent KSP Inhibitors.
University of Shizuoka
Discovery of novel spiro 1,3,4-thiadiazolines as potent, orally bioavailable and brain penetrant KSP inhibitors.
Merck Research Laboratories
Synthetic studies on mitotic kinesin Eg5 inhibitors: synthesis and structure-activity relationships of novel 2,4,5-substituted-1,3,4-thiadiazoline derivatives.
Kyowa Hakko Kirin
Design, synthesis and anticancer evaluation of tetrahydro-ß-carboline-hydantoin hybrids.
TBA
Optimization of diaryl amine derivatives as kinesin spindle protein inhibitors.
Kyoto University
Synthesis, biological evaluation and molecular docking studies of flavone and isoflavone derivatives as a novel class of KSP (kinesin spindle protein) inhibitors.
Nanjing University
Resistance by allostery: a novel perspective for eg5-targeted drug design.
Korea Institute of Science and Technology
Mitotic kinesin Eg5 overcomes inhibition to the phase I/II clinical candidate SB743921 by an allosteric resistance mechanism.
The Beatson Institute For Cancer Research
Advances in the discovery of kinesin spindle protein (Eg5) inhibitors as antitumor agents.
Cairo University
Optimized S-trityl-L-cysteine-based inhibitors of kinesin spindle protein with potent in vivo antitumor activity in lung cancer xenograft models.
The Beatson Institute For Cancer Research
Discovery of coumarin-monastrol hybrid as potential antibreast tumor-specific agent.
Csir-Central Drug Research Institute
Doing the methylene shuffle--further insights into the inhibition of mitotic kinesin Eg5 with S-trityl L-cysteine.
University of Strathclyde
Receptor-ligand interaction-based virtual screening for novel Eg5/kinesin spindle protein inhibitors.
Korea Institute of Science and Technology
Triphenylbutanamines: kinesin spindle protein inhibitors with in vivo antitumor activity.
The Beatson Institute For Cancer Research
The discovery and optimization of hexahydro-2H-pyrano[3,2-c]quinolines (HHPQs) as potent and selective inhibitors of the mitotic kinesin-5.
Merck Serono
Synthesis and SAR of pyrrolotriazine-4-one based Eg5 inhibitors.
Bristol-Myers Squibb Pharmaceutical Research Institute
Recent progress in biological activities of synthesized phenothiazines.
The Medical University of Silesia
Discovery of (+)-N-(3-aminopropyl)-N-[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-4-methylbenzamide (AZD4877), a kinesin spindle protein inhibitor and potential anticancer agent.
Astrazeneca
De novo design, synthesis and biological evaluation of 1,4-dihydroquinolin-4-ones and 1,2,3,4-tetrahydroquinazolin-4-ones as potent kinesin spindle protein (KSP) inhibitors.
China Pharmaceutical University
Synthesis and characterization of tritylthioethanamine derivatives with potent KSP inhibitory activity.
New Mexico State University
Synthesis and biological evaluation of conformationally flexible as well as restricted dimers of monastrol and related dihydropyrimidones.
Indian Institute of Chemical Technology
Structure-activity relationships of carboline and carbazole derivatives as a novel class of ATP-competitive kinesin spindle protein inhibitors.
Kyoto University
Structure-activity relationship and multidrug resistance study of new S-trityl-L-cysteine derivatives as inhibitors of Eg5.
Institute For Cancer Research
Design, synthesis and bioevaluation of dihydropyrazolo[3,4-b]pyridine and benzo[4,5]imidazo[1,2-a]pyrimidine compounds as dual KSP and Aurora-A kinase inhibitors for anti-cancer agents.
China Pharmaceutical University
Structural basis for inhibition of Eg5 by dihydropyrimidines: stereoselectivity of antimitotic inhibitors enastron, dimethylenastron and fluorastrol.
Institute For Cancer Research
Kinesin spindle protein (KSP) inhibitors with 2,3-fused indole scaffolds.
Kyoto University
Discovery of tetrahydro-beta-carbolines as inhibitors of the mitotic kinesin KSP.
China Pharmaceutical University
The discovery of tetrahydro-beta-carbolines as inhibitors of the kinesin Eg5.
Novartis Institutes For Biomedical Research
Substituted benzimidazoles: A novel chemotype for small molecule hKSP inhibitors.
Schering-Plough Research Institute
Bis(hetero)aryl derivatives as unique kinesin spindle protein inhibitors.
University of Shizuoka
Structure of human Eg5 in complex with a new monastrol-based inhibitor bound in the R configuration.
Cnrs-Commissariat à
Kinesin spindle protein (KSP) inhibitors. Part 7: Design and synthesis of 3,3-disubstituted dihydropyrazolobenzoxazines as potent inhibitors of the mitotic kinesin KSP.
Merck Research Laboratories
Kinesin spindle protein (KSP) inhibitors. Part 6: Design and synthesis of 3,5-diaryl-4,5-dihydropyrazole amides as potent inhibitors of the mitotic kinesin KSP.
Merck Research Laboratories
Discovery of 2-(3-Benzamidopropanamido)thiazole-5-carboxylate Inhibitors of the Kinesin HSET (KIFC1) and the Development of Cellular Target Engagement Probes.
Institute of Cancer Research
Synthesis and biological evaluation of L-cysteine derivatives as mitotic kinesin Eg5 inhibitors.
University of Shizuoka
Kinesin spindle protein (KSP) inhibitors. Part V: discovery of 2-propylamino-2,4-diaryl-2,5-dihydropyrroles as potent, water-soluble KSP inhibitors, and modulation of their basicity by beta-fluorination to overcome cellular efflux by P-glycoprotein.
Merck Research Laboratories
A comprehensive overview of β-carbolines and its derivatives as anticancer agents.
Xinyang Normal University
A review of synthetic bioactive tetrahydro-β-carbolines: A medicinal chemistry perspective.
Northwest A&F University
Targeting the Mitotic Kinesin KIF18A in Chromosomally Unstable Cancers: Hit Optimization Toward an In Vivo Chemical Probe.
Amgen Research
Kinesin spindle protein (KSP) inhibitors. Part 3: synthesis and evaluation of phenolic 2,4-diaryl-2,5-dihydropyrroles with reduced hERG binding and employment of a phosphate prodrug strategy for aqueous solubility.
Merck Research Laboratories
Kinesin spindle protein (KSP) inhibitors. Part 1: The discovery of 3,5-diaryl-4,5-dihydropyrazoles as potent and selective inhibitors of the mitotic kinesin KSP.
Merck Research Laboratories
Design, synthesis, and bioactivity of dihydropyrimidine derivatives as kinesin spindle protein inhibitors.
Tanta University
Design and synthesis of novel phenyl -1, 4-beta-carboline-hybrid molecules as potential anticancer agents.
Karnatak University
Crystal structure of the Eg5 - K858 complex and implications for structure-based design of thiadiazole-containing inhibitors.
University College London
Synthesis and anticancer activity of new dihydropyrimidinone derivatives.
Mansoura University
Design and synthesis of novel thiadiazole-thiazolone hybrids as potential inhibitors of the human mitotic kinesin Eg5.
University of Kwazulu-Natal (Ukzn)
Synthesis of N-(1-(6-acetamido-5-phenylpyrimidin-4-yl) piperidin-3-yl) amide derivatives as potential inhibitors for mitotic kinesin spindle protein.
Alagappa University
PHARMACEUTICALLY ACCEPTABLE SALT OF PYRAZOLOHETEROARYL DERIVATIVE AND CRYSTAL FORM THEREOF
Jiangsu Hengrui Pharmaceuticals
Phosphonate derivatives and methods of use thereof in the treatment of Alzheimer's disease
University of Kansas
Potent human immunodeficiency virus type 1 protease inhibitors that utilize noncoded D-amino acids as P2/P3 ligands.
Eli Lilly