35 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
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Synthesis, antiproliferative and pro-apoptotic activity of 2-phenylindoles.
Trinity College
Probing a 3,4'-bis-guanidinium diaryl derivative as an allosteric inhibitor of the Ras pathway.
Trinity College
a2-adrenoceptor antagonists: synthesis, pharmacological evaluation, and molecular modeling investigation of pyridinoguanidine, pyridino-2-aminoimidazoline and their derivatives.
Trinity College
ß-Lactam estrogen receptor antagonists and a dual-targeting estrogen receptor/tubulin ligand.
Trinity College
Guanidine-baseda2-adrenoceptor ligands: Towards selective antagonist activity.
Trinity College
Basic N-interlinked imipramines show apoptotic activity against malignant cells including Burkitt's lymphoma.
Trinity College
"True" antiandrogens-selective non-ligand-binding pocket disruptors of androgen receptor-coactivator interactions: novel tools for prostate cancer.
Trinity College
Integrated virtual screening for the identification of novel and selective peroxisome proliferator-activated receptor (PPAR) scaffolds.
Trinity College
Design of barbiturate-nitrate hybrids that inhibit MMP-9 activity and secretion.
Trinity College
Virtual screening for the identification of novel nonsteroidal glucocorticoid modulators.
Trinity College
Isosorbide-2-benzyl carbamate-5-salicylate, a peripheral anionic site binding subnanomolar selective butyrylcholinesterase inhibitor.
Trinity College
Inactivation of O6-alkylguanine-DNA alkyltransferase. 1. Novel O6-(hetarylmethyl)guanines having basic rings in the side chain.
Trinity College
Lead identification ofß-lactam and related imine inhibitors of the molecular chaperone heat shock protein 90.
Trinity College
Concise synthesis and CDK/GSK inhibitory activity of the missing 9-azapaullones.
Trinity College
Identification of plasmepsin inhibitors as selective anti-malarial agents using ligand based drug design.
Trinity College
Towards more specific O6-methylguanine-DNA methyltransferase (MGMT) inactivators.
Trinity College
Chemical target validation studies of aminopeptidase in malaria parasites using alpha-aminoalkylphosphonate and phosphonopeptide inhibitors.
Trinity College
Synthesis and serotonin transporter activity of 1,3-bis(aryl)-2-nitro-1-propenes as a new class of anticancer agents.
Trinity College
Synthesis and in vitro toxicity of 4-MTA, its characteristic clandestine synthesis byproducts and related sulfur substituted alpha-alkylthioamphetamines.
Trinity College
Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents.
Trinity College
Isosorbide-based cholinesterase inhibitors; replacement of 5-ester groups leading to increased stability.
Trinity College
Integration of ligand and structure-based virtual screening for the identification of the first dual targeting agent for heat shock protein 90 (Hsp90) and tubulin.
Trinity College
Synthesis, biological evaluation, structural-activity relationship, and docking study for a series of benzoxepin-derived estrogen receptor modulators.
Trinity College
Isosorbide-2-carbamate esters: potent and selective butyrylcholinesterase inhibitors.
Trinity College
Target specific virtual screening: optimization of an estrogen receptor screening platform.
Trinity College
Synthesis and evaluation of squaramide and thiosquaramide inhibitors of the DNA repair enzyme SNM1A.
Trinity College
Di-aryl guanidinium derivatives: Towards improved α2-Adrenergic affinity and antagonist activity.
Trinity College
Optimisation of estrogen receptor subtype-selectivity of a 4-Aryl-4H-chromene scaffold previously identified by virtual screening.
Trinity College
Substituted conformationally restricted guanidine derivatives: Probing the α2-adrenoceptors' binding pocket.
Trinity College
Flexible estrogen receptor modulators: design, synthesis, and antagonistic effects in human MCF-7 breast cancer cells.
Trinity College
Lead Optimization of Benzoxepin-Type Selective Estrogen Receptor (ER) Modulators and Downregulators with Subtype-Specific ERα and ERβ Activity.
Trinity College