20 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
PMID
Data
Article Title
Organization
Synthesis and biological evaluation of a unique heparin mimetic hexasaccharide for structure-activity relationship studies.
Momenta Pharmaceuticals
The discovery of novel N-(2-pyrimidinylamino) benzamide derivatives as potent hedgehog signaling pathway inhibitors.
Jiangsu Simcere Pharmaceutical
Discovery of pyrrolo[3,2-c]quinoline-4-one derivatives as novel hedgehog signaling inhibitors.
Takeda Pharmaceutical
Novel oxysterols activate the Hedgehog pathway and induce osteogenesis.
Fate Therapeutics
Discovery of the investigational drug TAK-441, a pyrrolo[3,2-c]pyridine derivative, as a highly potent and orally active hedgehog signaling inhibitor: modification of the core skeleton for improved solubility.
Takeda Pharmaceutical
Macrocycles are great cycles: applications, opportunities, and challenges of synthetic macrocycles in drug discovery.
Universite£
Potent small molecule Hedgehog agonists induce VEGF expression in vitro.
Universit£T Leipzig
Macrocyclic Hedgehog Pathway Inhibitors: Optimization of Cellular Activity and Mode of Action Studies.
TBA
Hedgehog-Gli signaling pathway inhibitors as anticancer agents.
St. Jude Children'S Research Hospital
Synthesis and biological evaluation of desmethylveramiline, a micromolar Hedgehog inhibitor.
University of Strasburg
Identification, characterization, and implications of species-dependent plasma protein binding for the oral Hedgehog pathway inhibitor vismodegib (GDC-0449).
Genentech
Purmorphamine activates the Hedgehog pathway by targeting Smoothened.
Stanford University School of Medicine
A small molecule that binds Hedgehog and blocks its signaling in human cells.
Broad Institute of Harvard and Massachusetts Institute of Technology
Syntheses of aminoalcohol-derived macrocycles leading to a small-molecule binder to and inhibitor of Sonic Hedgehog.
Massachusetts General Hospital
Synthesis and biological evaluation of SANT-2 and analogues as inhibitors of the hedgehog signaling pathway.
University of Leipzig
Current approaches and strategies to identify Hedgehog signaling pathway inhibitors for cancer therapy.
Peking Union Medical College
Cyclic Peptide Screening Methods for Preclinical Drug Discovery.
University of Washington
Inhibiting Hedgehog: An Update on Pharmacological Compounds and Targeting Strategies.
Philipps University Marburg
