Compile Data Set for Download or QSAR
Report error Found 36 Enz. Inhib. hit(s) with all data for entry = 50038863
TargetSonic hedgehog protein(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50249181(N-(4-chlorobenzyl)-2-((2R,6S,E)-5,12-dioxo-2-pheny...)
Affinity DataKd:  3.10E+3nMAssay Description:Binding affinity to SHHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50249182((1'S,2S,2'R,3R,3aS,6S,7aR,10'S,11'S)-2',3,6,16'-te...)
Affinity DataEC50:  200nMAssay Description:Inhibition of SHH-mediated mouse C3H10T1/2 cells differentiation into osteoblasts by alkaline phosphatase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50249520(N-(4-chloro-3-(5-(dimethylamino)-1H-benzo[d]imidaz...)
Affinity DataEC50:  40nMAssay Description:Inhibition of SHH in mouse Shh Light2 cells by GLI-responsive firefly luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50232973(CHEMBL254129 | CYCLOPAMINE)
Affinity DataEC50:  500nMAssay Description:Inhibition of SHH in mouse Shh Light2 cells by GLI-responsive firefly luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50249185(4-(4-cyclopropylquinazolin-2-ylamino)-N-(2,6-dimet...)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of SHH-mediated mouse C3H10T1/2 cells differentiation into osteoblasts by alkaline phosphatase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)
Affinity DataIC50: 3nMAssay Description:Inhibition of SHH in mouse Shh Light2 cells by GLI-responsive firefly luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50249186(N-(2,6-dimethylphenyl)-4-(4-phenylpyrido[2,3-d]pyr...)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of SHH-mediated mouse C3H10T1/2 cells differentiation into osteoblasts by alkaline phosphatase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50249184(N-(1-methyl-1,2,3,4-tetrahydroquinolin-7-yl)-4-(4-...)
Affinity DataIC50: 5.80nMAssay Description:Inhibition of SHH-mediated mouse C3H10T1/2 cells differentiation into osteoblasts by alkaline phosphatase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50249488(4-benzyl-N-((3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl...)
Affinity DataIC50: 20nMAssay Description:Inhibition of SHH-mediated mouse C3H10T1/2 cells differentiation into osteoblasts by alkaline phosphatase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50249489(N-(3-(1H-Benzo[d]imidazol-2-yl)-4-chlorophenyl)-3,...)
Affinity DataIC50: 30nMAssay Description:Inhibition of SHH-mediated mouse C3H10T1/2 cells differentiation into osteoblasts by alkaline phosphatase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50249523(N-(4-ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridi...)
Affinity DataIC50: 30nMAssay Description:Inhibition of SHH in mouse Shh Light2 cells by GLI-responsive firefly luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50249517(6-cyclopropyl-4-(4-methoxyphenyl)-2-(2-oxopropylth...)
Affinity DataIC50: 100nMAssay Description:Inhibition of SHH-mediated mouse C3H10T1/2 cells differentiation into osteoblasts by alkaline phosphatase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50249553(N-(4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2...)
Affinity DataIC50: 100nMAssay Description:Inhibition of SHH in mouse Shh Light2 cells by GLI-responsive firefly luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50249555(4-(pyridin-2-yl)-N-p-tolylthiazol-2-amine | GNF-Pf...)
Affinity DataIC50: 100nMAssay Description:Inhibition of SHH in mouse Shh Light2 cells by GLI-responsive firefly luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50249554(1-(3-(4-phenylthiazol-2-ylamino)phenyl)ethanone | ...)
Affinity DataIC50: 100nMAssay Description:Inhibition of SHH in mouse Shh Light2 cells by GLI-responsive firefly luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50249556(N-(5-chloro-2-methoxyphenyl)-4-(pyridin-3-yl)thiaz...)
Affinity DataIC50: 100nMAssay Description:Inhibition of SHH in mouse Shh Light2 cells by GLI-responsive firefly luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetSonic hedgehog protein(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50249519(N-((3S,5S)-1-(benzo[d][1,3]dioxol-5-ylmethyl)-5-(p...)
Affinity DataIC50: 100nMAssay Description:Inhibition of lipid-modified (octylated) form of SHH expressed in mouse s12 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50249518((E)-3-(4-(5-pentylpyridin-2-yl)phenyl)-1-(piperidi...)
Affinity DataIC50: 200nMAssay Description:Inhibition of SHH-mediated mouse C3H10T1/2 cells differentiation into osteoblasts by alkaline phosphatase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetSonic hedgehog protein(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50170645(5'-hydroxy-2',3,6,15'-tetramethyl-(1'S,2'R,2'R,3R,...)
Affinity DataIC50: 500nMAssay Description:Inhibition of lipid-modified (octylated) form of SHH expressed in mouse s12 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetZinc finger protein GLI1(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50378034(NSC-287088 | PHYSALIN B | CHEMBL504404)
Affinity DataIC50: 620nMAssay Description:Inhibition of Gli1-mediated transcription expressed in human PANC1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetZinc finger protein GLI1(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50378033(PHYSALIN F)
Affinity DataIC50: 660nMAssay Description:Inhibition of Gli1-mediated transcription expressed in human PANC1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetZinc finger protein GLI2(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50241296(Zerumbone | CHEMBL245412)
Affinity DataIC50: 910nMAssay Description:Inhibition of Gli2-mediated transcription expressed in human PANC1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetZinc finger protein GLI1(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM2581(CHEMBL16958 | 3,13,23-triazahexacyclo[14.7.0.0^{2,...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of Gli1-mediated transcription expressed in human PANC1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetZinc finger protein GLI1(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50240978(5,6-dihydroxy-8,9-dihydro-1H-indolo[2,3-a]pyrrolo[...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of Gli1-mediated transcription expressed in human PANC1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetZinc finger protein GLI1(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50240682(2,10-dihydroxy-6,7,12,13-tetrahydro-5H-indolo[2,3-...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of Gli1-mediated transcription expressed in human PANC1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetZinc finger protein GLI1(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50240964(2-hydroxy-6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyr...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of Gli1-mediated transcription expressed in human PANC1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetZinc finger protein GLI2(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50240964(2-hydroxy-6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyr...)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of Gli2-mediated transcription expressed in human PANC1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetZinc finger protein GLI2(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50240682(2,10-dihydroxy-6,7,12,13-tetrahydro-5H-indolo[2,3-...)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of Gli2-mediated transcription expressed in human PANC1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetZinc finger protein GLI2(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50240978(5,6-dihydroxy-8,9-dihydro-1H-indolo[2,3-a]pyrrolo[...)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of Gli2-mediated transcription expressed in human PANC1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetZinc finger protein GLI2(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM2581(CHEMBL16958 | 3,13,23-triazahexacyclo[14.7.0.0^{2,...)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of Gli2-mediated transcription expressed in human PANC1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50249102(4-(3,4,5-tri(pyridin-4-yl)thiophen-2-yl)pyridine |...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of SHH in mouse Shh Light2 cells by GLI-responsive firefly luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50249557(2-((3-(2-(dimethylamino)benzyl)-2-(pyridin-4-yl)-t...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of SHH in mouse Shh Light2 cells by GLI-responsive firefly luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetZinc finger protein GLI1(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50241296(Zerumbone | CHEMBL245412)
Affinity DataIC50: 7.10E+3nMAssay Description:Inhibition of Gli1-mediated transcription expressed in human PANC1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetZinc finger protein GLI1(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM23208(cid_64971 | CHEMBL269277 | (1R,2R,5S,8R,9R,10R,13R...)
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of Gli1-mediated transcription expressed in human PANC1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetZinc finger protein GLI1(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50249140(colubrinic acid | CHEMBL470503)
Affinity DataIC50: 3.80E+4nMAssay Description:Inhibition of Gli1-mediated transcription expressed in human PANC1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetZinc finger protein GLI1(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50249188(Alphitolic acid | CHEMBL511805)
Affinity DataIC50: 4.20E+4nMAssay Description:Inhibition of Gli1-mediated transcription expressed in human PANC1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed