Compile Data Set for Download or QSAR
Report error Found 10 Enz. Inhib. hit(s) with all data for entry = 50015977
TargetKelch-like ECH-associated protein 1(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50590849(CHEMBL5176959)
Affinity DataKd:  110nMAssay Description:Binding affinity to Keap1 (unknown origin) assessed as dissociation constant by calorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetSonic hedgehog protein(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50590850(CHEMBL5185285)
Affinity DataKd:  550nMAssay Description:Binding affinity to SHH (unknown origin) assessed as dissociation constant by calorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50590855(CHEMBL5171791)
Affinity DataKd:  5.50E+3nMAssay Description:Binding affinity to MDM2 (unknown origin) by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetKelch-like ECH-associated protein 1(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50590849(CHEMBL5176959)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of Keap1 (unknown origin) by ELISA analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50590854(CHEMBL5203249)
Affinity DataIC50: 17nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50590855(CHEMBL5171791)
Affinity DataIC50: 600nMAssay Description:Inhibition of MDM2 (unknown origin) by Fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetGTPase KRas(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50590851(CHEMBL5201714)
Affinity DataIC50: 800nMAssay Description:Inhibition of human His-Avi-TEV-tagged KRAS G12D mutant expressed in Escherichia coli BL21(DE3) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetTranscription factor 4(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50590853(CHEMBL5172034)
Affinity DataIC50: 4.00E+3nMAssay Description:Binding affinity to FITC-labeled Tcf4 (unknown origin) /6His-tagged beta-catenin (135 to 668 residues) (unknown origin) protein-protein interaction a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetTranscription factor 4(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50590852(CHEMBL5202327)
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of FITC-labeled Tcf4 (unknown origin) / full length beta-catenin (1 to 781 residues) (unknown origin) protein-protein interaction measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetTranscription factor 4(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50589363(CHEMBL5191201)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of FITC-labeled Tcf4 (unknown origin) / full length beta-catenin (1 to 781 residues) (unknown origin) protein-protein interaction measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed