75 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
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Article Title
Organization
SAR Exploration Guided by LE and Fsp(3): Discovery of a Selective and Orally Efficacious ROR¿ Inhibitor.
Central Pharmaceutical Research Institute
Xanthones from the roots of Maclura cochinchinensis var. gerontogea and their retinoic acid receptor-a agonistic activity.
Aichi Gakuin University
Small molecule inhibitors targeting activator protein 1 (AP-1).
University of Texas Medical Branch
Identification of the first inverse agonist of retinoid-related orphan receptor (ROR) with dual selectivity for RORß and ROR¿t.
Phenex Pharmaceuticals
Inhibition of I¿B kinase-ß and I¿B kinase-a by heterocyclic adamantyl arotinoids.
Universidade De Vigo
Design, synthesis and evaluation of retinoids with novel bulky hydrophobic partial structures.
Research Foundation Itsuu Laboratory
Design, synthesis, and structure-activity analysis of isoform-selective retinoic acid receptor beta ligands.
Acadia Pharmaceuticals
Identification of diaryl ether-based ligands for estrogen-related receptora as potential antidiabetic agents.
Johnson & Johnson Pharmaceutical Research and Development
Retinoid receptor subtype-selective modulators through synthetic modifications of RARgamma agonists.
Universidade De Vigo
Toward the development of innovative bifunctional agents to induce differentiation and to promote apoptosis in leukemia: clinical candidates and perspectives.
Aristotle University of Thessaloniki
Synthesis and pharmacological validation of a novel series of non-steroidal FXR agonists.
Phenex Pharmaceuticals
Identification of a chromone-based retinoid containing a polyolefinic side chain via facile synthetic routes.
Temple University
Synthesis and structure-activity relationships of potent conformationally restricted retinoid X receptor ligands
TBA
Synthesis and biological activity of 1,2,3,4-tetrahydroquinoline and 3,4-(1H)-dihydroquinolin-2-one analogs of retinoic acid
TBA
Synthesis and receptor binding affinity of conformationally restricted retinoic acid analogues
TBA
Synthesis of highly potent RXR-specific retinoids: The use of a cyclopropyl group as a double bond isostere
TBA
Synthesis and pharmacological activity of conformationally restricted, acetylenic retinoid analogs
TBA
Differential RXR & RAR activity of stilbene retinoid analogs bearing thiazole and imidazole carboxylic acids
TBA
Novel non-carboxylic acid retinoids: 1,2,4-oxadiazol-5-one derivatives.
University of Lille
LLY-507, a Cell-active, Potent, and Selective Inhibitor of Protein-lysine Methyltransferase SMYD2.
Eli Lilly and Company
Strategies for developing retinoic acid receptor alpha-selective antagonists as novel agents for male contraception.
University of Minnesota
Development of a Potent Nurr1 Agonist Tool for In Vivo Applications.
Ludwig Maximilian University of Munich
Discovery of the First-in-Class Intestinal Restricted FXR and FABP1 Dual Modulator ZLY28 for the Treatment of Nonalcoholic Fatty Liver Disease.
Guangdong Pharmaceutical University
Bioactive Aurones, Indanones, and Other Hemiindigoid Scaffolds: Medicinal Chemistry and Photopharmacology Perspectives.
Universite Grenoble Alpes
Novel retinoic acid metabolism blocking agents endowed with multiple biological activities are efficient growth inhibitors of human breast and prostate cancer cells in vitro and a human breast tumor xenograft in nude mice.
University of Maryland
Design, synthesis and structure-activity relationship of novel RXR-selective modulators.
Ligand Pharmaceuticals
Design and synthesis of novel RXR-selective modulators with improved pharmacological profile.
Ligand Pharmaceuticals
Retinoic acid receptor ligands based on the 6-cyclopropyl-2,4-hexadienoic acid.
Ligand Pharmaceuticals
Synthesis and biological activity of retinoic acid receptor-alpha specific amides.
Allergan
Enantioselective syntheses of potent retinoid X receptor ligands: differential biological activities of individual antipodes.
Allergan
Syntheses and evaluation of quinoline derivatives as novel retinoic acid receptor alpha antagonists.
Eisai
Phenylcyclohexene and phenylcyclohexadiene substituted compounds having retinoid antagonist activity.
Allergan
Syntheses and evaluation of naphthalenyl- and chromenyl-pyrrolyl-benzoic acids as potent and selective retinoic acid receptor alpha agonists.
Eisai
Novel retinoic acid receptor alpha agonists: syntheses and evaluation of pyrazole derivatives.
Eisai
Tuning Nuclear Receptor Selectivity of Wy14,643 towards Selective Retinoid X Receptor Modulation.
Goethe University Frankfurt
Syntheses and structure-activity relationships of 5,6,7, 8-tetrahydro-5,5,8,8-tetramethyl-2-quinoxaline derivatives with retinoic acid receptor alpha agonistic activity.
Eisai
Structure-activity relationship studies of novel heteroretinoids: induction of apoptosis in the HL-60 cell line by a novel isoxazole-containing heteroretinoid.
Università
Heteroarotinoids inhibit head and neck cancer cell lines in vitro and in vivo through both RAR and RXR retinoic acid receptors.
University of Oklahoma Health Sciences Center
Discovery and lead optimisation of a potent, selective and orally bioavailable RARβ agonist for the potential treatment of nerve injury.
King'S College
Synthesis, structure-activity relationships, and RARgamma-ligand interactions of nitrogen heteroarotinoids.
University of Oklahoma Health Sciences Center
A new class of potent RAR antagonists: dihydroanthracenyl, benzochromenyl and benzothiochromenyl retinoids.
Allergan
Stereoselective synthesis and receptor activity of conformationally defined retinoid X receptor selective ligands.
Allergan
Synthesis of retinoid X receptor-specific ligands that are potent inducers of adipogenesis in 3T3-L1 cells.
Ligand Pharmaceuticals
Synthesis and characterization of heteroarotinoids demonstrate structure specificity relationships.
University of Oklahoma Health Sciences Center
Conformationally defined retinoic acid analogues. 4. Potential new agents for acute promyelocytic and juvenile myelomonocytic leukemias.
University of Alabama At Birmingham
Regulation of retinoidal actions by diazepinylbenzoic acids. Retinoid synergists which activate the RXR-RAR heterodimers.
University of Tokyo
Conformationally defined 6-s-trans-retinoic acid analogs. 3. Structure-activity relationships for nuclear receptor binding, transcriptional activity, and cancer chemopreventive activity.
University of Alabama At Birmingham
Synthesis and structure-activity relationships of retinoid X receptor selective diaryl sulfide analogs of retinoic acid.
Allergan
Identification of the first retinoid X, receptor homodimer antagonist.
Ligand Pharmaceuticals
Discovery of novel retinoic acid receptor agonists having potent antiproliferative activity in cervical cancer cells.
Ligand Pharmaceuticals
Retinoic acid receptor beta,gamma-selective ligands: synthesis and biological activity of 6-substituted 2-naphthoic acid retinoids.
Pharmaceutical Research Institute
Synthesis, structure-affinity relationships, and biological activities of ligands binding to retinoic acid receptor subtypes.
Cird Galderma
Conformational effects on retinoid receptor selectivity. 1. Effect of 9-double bond geometry on retinoid X receptor activity.
Sri International
Synthesis of high specific activity [3H]-9-cis-retinoic acid and its application for identifying retinoids with unusual binding properties.
Ligand Pharmaceuticals
Synthesis and structure-activity relationships of novel retinoid X receptor-selective retinoids.
Ligand Pharmaceuticals
Conformational effects on retinoid receptor selectivity. 2. Effects of retinoid bridging group on retinoid X receptor activity and selectivity.
Sri International
Synthesis and structure-activity relationships of stilbene retinoid analogs substituted with heteroaromatic carboxylic acids.
Allergan
Conformationally defined 6-s-trans-retinoic acid analogs. 2. Selective agonists for nuclear receptor binding and transcriptional activity.
University of Alabama At Birmingham
Synthesis and characterization of a highly potent and effective antagonist of retinoic acid receptors.
Allergan
Identification of highly potent retinoic acid receptor alpha-selective antagonists.
Allergan
Probing biological activity through structural modelling of ligand-receptor interactions of 2,4-disubstituted thiazole retinoids.
Helwan University
Structure-based design of Trifarotene (CD5789), a potent and selective RARγ agonist for the treatment of acne.
Nestle Skin Health
Design and synthesis of a potent, highly selective, orally bioavailable, retinoic acid receptor alpha agonist.
King'S College
Natural-Products-Inspired Use of the gem-Dimethyl Group in Medicinal Chemistry.
St. John'S University
