Compile Data Set for Download or QSAR
Report error Found 21 Enz. Inhib. hit(s) with all data for entry = 50032473
TargetMast/stem cell growth factor receptor Kit(Human)
Aristotle University of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50300690(CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...)
Affinity DataKd:  1.60nMAssay Description:Binding affinity to cKITMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetRetinoic acid receptor gamma(Human)
Aristotle University of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50061625(4-[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthal...)
Affinity DataEC50:  591nMAssay Description:Agonist activity at RARgammaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetRetinoic acid receptor beta(Human)
Aristotle University of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50061625(4-[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthal...)
Affinity DataEC50:  235nMAssay Description:Agonist activity at RARbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetRetinoic acid receptor alpha(Human)
Aristotle University of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50061625(4-[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthal...)
Affinity DataEC50:  45nMAssay Description:Agonist activity at RARalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetCathepsin G(Human)
Aristotle University of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50329819((R)-1-((2S,3R)-3-hydroxy-2-(6-phenylpicolinamido)b...)
Affinity DataEC50:  13.5nMAssay Description:Inhibition of cathepsin G in human MOLT4 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Aristotle University of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50300690(CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...)
Affinity DataKd:  1.60nMAssay Description:Binding affinity to CSF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Aristotle University of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50300690(CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...)
Affinity DataKd:  1.60nMAssay Description:Binding affinity to RETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Aristotle University of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50300690(CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...)
Affinity DataKd:  1.60nMAssay Description:Binding affinity to PDGFRbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Aristotle University of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50300690(CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...)
Affinity DataKd:  1.60nMAssay Description:Binding affinity to PDGFRalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Aristotle University of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50300690(CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...)
Affinity DataKd:  1.60nMAssay Description:Binding affinity to FLT3More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4(Human)
Aristotle University of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM6309(8-cyclopentyl-6-acetyl-5-methyl-2-{[5-(piperazin-1...)
Affinity DataIC50: 11nMAssay Description:Inhibition of CDK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetCathepsin G(Human)
Aristotle University of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50329819((R)-1-((2S,3R)-3-hydroxy-2-(6-phenylpicolinamido)b...)
Affinity DataIC50: 13.7nMAssay Description:Inhibition of cathepsin GMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase 6(Human)
Aristotle University of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM6309(8-cyclopentyl-6-acetyl-5-methyl-2-{[5-(piperazin-1...)
Affinity DataIC50: 16nMAssay Description:Inhibition of CDK6More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBcl-2-like protein 1(Human)
Aristotle University of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM21400(N-[(4-{[(2R)-4-(dimethylamino)-1-(phenylsulfanyl)b...)
Affinity DataKi:  0.800nMAssay Description:Binding affinity to Bcl-xlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetApoptosis regulator Bcl-2(Human)
Aristotle University of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM21447(4-(4-{[2-(4-chlorophenyl)phenyl]methyl}piperazin-1...)
Affinity DataKi:  8nMAssay Description:Binding affinity to BCl2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Aristotle University of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM21447(4-(4-{[2-(4-chlorophenyl)phenyl]methyl}piperazin-1...)
Affinity DataKi:  30nMAssay Description:Binding affinity to Bcl-xlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Aristotle University of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50270877(ABT-263 | (R)-4-(4-((2-(4-chlorophenyl)-5,5-dimeth...)
Affinity DataKi:  36nMAssay Description:Binding affinity to Bcl-xlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetApoptosis regulator Bcl-2(Human)
Aristotle University of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM21400(N-[(4-{[(2R)-4-(dimethylamino)-1-(phenylsulfanyl)b...)
Affinity DataKi:  62nMAssay Description:Binding affinity to BCl2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Aristotle University of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM23223(Tash 1 | Gossypol, 4 | 7-[8-formyl-1,6,7-trihydrox...)
Affinity DataKi:  180nMAssay Description:Binding affinity to MCL1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetApoptosis regulator Bcl-2(Human)
Aristotle University of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM23223(Tash 1 | Gossypol, 4 | 7-[8-formyl-1,6,7-trihydrox...)
Affinity DataKi:  320nMAssay Description:Binding affinity to BCl2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Aristotle University of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM23223(Tash 1 | Gossypol, 4 | 7-[8-formyl-1,6,7-trihydrox...)
Affinity DataKi:  480nMAssay Description:Binding affinity to Bcl-xlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed