45 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
PMID
Data
Article Title
Organization
Design and synthesis of curcumin derivatives as tau and amyloidß dual aggregation inhibitors.
Doshisha University
Design, Synthesis, and Characterization of 3-(Benzylidene)indolin-2-one Derivatives as Ligands fora-Synuclein Fibrils.
Washington University
Development of dual targeting inhibitors against aggregations of amyloid-ß and tau protein.
Tokyo Institute of Technology
Imidazo[2,1]thiazol-3-one Derivatives Useful as Diagnostic Agents for Alzheimer's Disease.
Temple University
Synthesis and biological evaluation of novel styryl benzimidazole derivatives as probes for imaging of neurofibrillary tangles in Alzheimer's disease.
Kyoto University
Progress and developments in tau aggregation inhibitors for Alzheimer disease.
Humboldt Universit£T Zu Berlin
Target- and mechanism-based therapeutics for neurodegenerative diseases: strength in numbers.
Northwestern University
2-Styrylindolium based fluorescent probes visualize neurofibrillary tangles in Alzheimer's disease.
Technische Universit£T Darmstadt
Evaluation of [(11)C]N-Methyl Lansoprazole as a Radiopharmaceutical for PET Imaging of Tau Neurofibrillary Tangles.
TBA
Bis(arylvinyl)pyrazines, -pyrimidines, and -pyridazines as imaging agents for tau fibrils andß-amyloid plaques in Alzheimer's disease models.
Technische Universit£T Darmstadt
Synthesis and biological evaluation of novel oxindole derivatives for imaging neurofibrillary tangles in Alzheimer's disease.
Kyoto University
(18)F-labeled phenyldiazenyl benzothiazole for in vivo imaging of neurofibrillary tangles in Alzheimer's disease brains.
TBA
Structure-activity relationship study of 2,4-diaminothiazoles as Cdk5/p25 kinase inhibitors.
Harvard Medical School
Rational design of potent GSK3beta inhibitors with selectivity for Cdk1 and Cdk2.
Sanofi-Aventis
Multicomponent Petasis reaction for the identification of pyrazine based multi-target directed anti-Alzheimer's agents: In-silico design, synthesis, and characterization.
Jamia Millia Islamia
Thioxanthenone-based derivatives as multitarget therapeutic leads for Alzheimer's disease.
University of Genoa
Synthesis and structure-activity relationship (SAR) studies of 1,2,3-triazole, amide, and ester-based benzothiazole derivatives as potential molecular probes for tau protein.
University of Wollongong
Design, Structure-Activity Relationships, and In Vivo Evaluation of Potent and Brain-Penetrant Imidazo[1,2-
Biocon-Bristol Myers Squibb Research and Development Center
Structure-activity relationship (SAR) studies on substituted N-(pyridin-3-yl)-2-amino-isonicotinamides as highly potent and selective glycogen synthase kinase-3 (GSK-3) inhibitors.
Bristol-Myers Squibb
Imidazo[1,2-b]pyridazine as privileged scaffold in medicinal chemistry: An extensive review.
Universite de Tours
PROTACs to address the challenges facing small molecule inhibitors.
Oregon Health & Science University
Amyloid-β and tau aggregation dual-inhibitors: A synthetic and structure-activity relationship focused review.
University of Aveiro
Small molecule therapeutics for tauopathy in Alzheimer's disease: Walking on the path of most resistance.
Karolinska Institutet
Structure-activity relationship around PI-2620 highlights the importance of the nitrogen atom position in the tricyclic core.
Ac Immune
Advancement of multi-target drug discoveries and promising applications in the field of Alzheimer's disease.
Jining Medical University
Regioselective synthesis of 7-O-esters of the flavonolignan silibinin and SARs lead to compounds with overadditive neuroprotective effects.
Julius-Maximilians-Universit£T W£Rzburg
Discovery of a Keap1-dependent peptide PROTAC to knockdown Tau by ubiquitination-proteasome degradation pathway.
China Pharmaceutical University
Pyridine, pyrazine, and triazine compounds as allosteric SHP2 inhibitors
Revolution Medicines
Substituted azetidine dihydrothienopyrimidines and their use as phosphodiesterase inhibitors
Union Therapeutics
Compounds, formulations, and methods of protein kinase C inhibition
University of Michigan
Nitrocinnamoyl and chlorocinnamoyl derivatives of dihydrocodeinone: in vivo and in vitro characterization of mu-selective agonist and antagonist activity.
University of Rochester