Compile Data Set for Download or QSAR
Report error Found 58 Enz. Inhib. hit(s) with all data for entry = 50017362
TargetAmyloid-beta precursor protein(Human)
University of Aveiro

Curated by ChEMBL
LigandPNGBDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US9409845, Tab...)
Affinity DataIC50: 107nMAssay Description:Inhibition of amyloid beta 42 transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetAmyloid-beta precursor protein(Human)
University of Aveiro

Curated by ChEMBL
LigandPNGBDBM50163745(4-((E)-2-{3-[(E)-2-(4-hydroxy-3-methoxyphenyl)viny...)
Affinity DataIC50: 138nMAssay Description:Inhibition of amyloid beta 42 transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetAmyloid-beta precursor protein(Human)
University of Aveiro

Curated by ChEMBL
LigandPNGBDBM50163748(4-(2-(5-(4-hydroxy-3-methoxystyryl)-1H-pyrazol-3-y...)
Affinity DataIC50: 476nMAssay Description:Inhibition of amyloid beta 42 transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetAmyloid-beta precursor protein(Human)
University of Aveiro

Curated by ChEMBL
LigandPNGBDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US9409845, Tab...)
Affinity DataIC50: 900nMAssay Description:Inhibition of amyloid beta (unknown origin) incubated for 7 days by sandwich ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetAmyloid-beta precursor protein(Human)
University of Aveiro

Curated by ChEMBL
LigandPNGBDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US9409845, Tab...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of amyloid beta 40 (unknown origin) assessed as disaggregation of fibrillar amyloid beta 40 incubated for 3 days by ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetAmyloid-beta precursor protein(Human)
University of Aveiro

Curated by ChEMBL
LigandPNGBDBM50601428(CHEMBL5175279)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of amyloid beta 42 transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetAmyloid-beta precursor protein(Human)
University of Aveiro

Curated by ChEMBL
LigandPNGBDBM50601427(CHEMBL5176644)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of amyloid beta 42 transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetAmyloid-beta precursor protein(Human)
University of Aveiro

Curated by ChEMBL
LigandPNGBDBM50601426(CHEMBL5200280)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of amyloid beta 42 transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetAmyloid-beta precursor protein(Human)
University of Aveiro

Curated by ChEMBL
LigandPNGBDBM50601425(CHEMBL5189854)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of amyloid beta 42 transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetAmyloid-beta precursor protein(Human)
University of Aveiro

Curated by ChEMBL
LigandPNGBDBM50391730(CHEMBL258741)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of amyloid beta 42 transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetAmyloid-beta precursor protein(Human)
University of Aveiro

Curated by ChEMBL
LigandPNGBDBM50601424(CHEMBL5209194)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of amyloid beta 42 transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetAmyloid-beta precursor protein(Human)
University of Aveiro

Curated by ChEMBL
LigandPNGBDBM50601423(CHEMBL5195740)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of amyloid beta 42 transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetAmyloid-beta precursor protein(Human)
University of Aveiro

Curated by ChEMBL
LigandPNGBDBM50601422(CHEMBL5174150)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of amyloid beta 42 transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetMicrotubule-associated protein tau(Human)
University of Aveiro

Curated by ChEMBL
LigandPNGBDBM50601425(CHEMBL5189854)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of tau (unknown origin) transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetAmyloid-beta precursor protein(Human)
University of Aveiro

Curated by ChEMBL
LigandPNGBDBM50601425(CHEMBL5189854)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of amyloid beta 42 secretion transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetAmyloid-beta precursor protein(Human)
University of Aveiro

Curated by ChEMBL
LigandPNGBDBM50601431(CHEMBL5183237)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of amyloid beta 42 secretion transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetAmyloid-beta precursor protein(Human)
University of Aveiro

Curated by ChEMBL
LigandPNGBDBM50601428(CHEMBL5175279)
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of amyloid beta 42 secretion transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetAmyloid-beta precursor protein(Human)
University of Aveiro

Curated by ChEMBL
LigandPNGBDBM50601426(CHEMBL5200280)
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of amyloid beta 42 secretion transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetMicrotubule-associated protein tau(Human)
University of Aveiro

Curated by ChEMBL
LigandPNGBDBM50553256(CHEMBL258632 | N-(3-Nitrophenylpyrazole)Curcumin)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of tau (unknown origin) transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetAmyloid-beta precursor protein(Human)
University of Aveiro

Curated by ChEMBL
LigandPNGBDBM50601427(CHEMBL5176644)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of amyloid beta 42 secretion transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetAmyloid-beta precursor protein(Human)
University of Aveiro

Curated by ChEMBL
LigandPNGBDBM50601426(CHEMBL5200280)
Affinity DataIC50: 5.40E+3nMAssay Description:Inhibition of amyloid beta 40 secretion transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetAmyloid-beta precursor protein(Human)
University of Aveiro

Curated by ChEMBL
LigandPNGBDBM50601425(CHEMBL5189854)
Affinity DataIC50: 6.20E+3nMAssay Description:Inhibition of amyloid beta 40 secretion transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetAmyloid-beta precursor protein(Human)
University of Aveiro

Curated by ChEMBL
LigandPNGBDBM50601431(CHEMBL5183237)
Affinity DataIC50: 6.30E+3nMAssay Description:Inhibition of amyloid beta 40 secretion transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetAmyloid-beta precursor protein(Human)
University of Aveiro

Curated by ChEMBL
LigandPNGBDBM50163745(4-((E)-2-{3-[(E)-2-(4-hydroxy-3-methoxyphenyl)viny...)
Affinity DataIC50: 6.80E+3nMAssay Description:Inhibition of amyloid beta 42 secretion transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetAmyloid-beta precursor protein(Human)
University of Aveiro

Curated by ChEMBL
LigandPNGBDBM50601428(CHEMBL5175279)
Affinity DataIC50: 6.90E+3nMAssay Description:Inhibition of amyloid beta 40 secretion transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetAmyloid-beta precursor protein(Human)
University of Aveiro

Curated by ChEMBL
LigandPNGBDBM50163745(4-((E)-2-{3-[(E)-2-(4-hydroxy-3-methoxyphenyl)viny...)
Affinity DataIC50: 7.40E+3nMAssay Description:Inhibition of amyloid beta 40 secretion transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetAmyloid-beta precursor protein(Human)
University of Aveiro

Curated by ChEMBL
LigandPNGBDBM50601427(CHEMBL5176644)
Affinity DataIC50: 8.70E+3nMAssay Description:Inhibition of amyloid beta 40 secretion transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetAmyloid-beta precursor protein(Human)
University of Aveiro

Curated by ChEMBL
LigandPNGBDBM50163748(4-(2-(5-(4-hydroxy-3-methoxystyryl)-1H-pyrazol-3-y...)
Affinity DataIC50: 8.70E+3nMAssay Description:Inhibition of amyloid beta 42 secretion transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetAmyloid-beta precursor protein(Human)
University of Aveiro

Curated by ChEMBL
LigandPNGBDBM50601429(CHEMBL492807)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of amyloid beta 42 secretion transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetAmyloid-beta precursor protein(Human)
University of Aveiro

Curated by ChEMBL
LigandPNGBDBM50163748(4-(2-(5-(4-hydroxy-3-methoxystyryl)-1H-pyrazol-3-y...)
Affinity DataIC50: 9.70E+3nMAssay Description:Inhibition of amyloid beta 40 secretion transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetMicrotubule-associated protein tau(Human)
University of Aveiro

Curated by ChEMBL
LigandPNGBDBM50601431(CHEMBL5183237)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of tau (unknown origin) transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetAmyloid-beta precursor protein(Human)
University of Aveiro

Curated by ChEMBL
LigandPNGBDBM50601429(CHEMBL492807)
Affinity DataIC50: 1.04E+4nMAssay Description:Inhibition of amyloid beta 40 secretion transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetAmyloid-beta precursor protein(Human)
University of Aveiro

Curated by ChEMBL
LigandPNGBDBM50391730(CHEMBL258741)
Affinity DataIC50: 1.13E+4nMAssay Description:Inhibition of amyloid beta 40 secretion transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetAmyloid-beta precursor protein(Human)
University of Aveiro

Curated by ChEMBL
LigandPNGBDBM50601424(CHEMBL5209194)
Affinity DataIC50: 1.15E+4nMAssay Description:Inhibition of amyloid beta 40 secretion transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetMicrotubule-associated protein tau(Human)
University of Aveiro

Curated by ChEMBL
LigandPNGBDBM50601429(CHEMBL492807)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of tau (unknown origin) transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetAmyloid-beta precursor protein(Human)
University of Aveiro

Curated by ChEMBL
LigandPNGBDBM50601423(CHEMBL5195740)
Affinity DataIC50: 1.41E+4nMAssay Description:Inhibition of amyloid beta 40 secretion transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetAmyloid-beta precursor protein(Human)
University of Aveiro

Curated by ChEMBL
LigandPNGBDBM50391730(CHEMBL258741)
Affinity DataIC50: 1.42E+4nMAssay Description:Inhibition of amyloid beta 42 secretion transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetAmyloid-beta precursor protein(Human)
University of Aveiro

Curated by ChEMBL
LigandPNGBDBM50553256(CHEMBL258632 | N-(3-Nitrophenylpyrazole)Curcumin)
Affinity DataIC50: 1.42E+4nMAssay Description:Inhibition of amyloid beta 42 secretion transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetAmyloid-beta precursor protein(Human)
University of Aveiro

Curated by ChEMBL
LigandPNGBDBM50553256(CHEMBL258632 | N-(3-Nitrophenylpyrazole)Curcumin)
Affinity DataIC50: 1.51E+4nMAssay Description:Inhibition of amyloid beta 40 secretion transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetAmyloid-beta precursor protein(Human)
University of Aveiro

Curated by ChEMBL
LigandPNGBDBM50601424(CHEMBL5209194)
Affinity DataIC50: 1.53E+4nMAssay Description:Inhibition of amyloid beta 42 secretion transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetAmyloid-beta precursor protein(Human)
University of Aveiro

Curated by ChEMBL
LigandPNGBDBM50601430(CHEMBL5205561)
Affinity DataIC50: 1.73E+4nMAssay Description:Inhibition of amyloid beta 42 secretion transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetAmyloid-beta precursor protein(Human)
University of Aveiro

Curated by ChEMBL
LigandPNGBDBM50601430(CHEMBL5205561)
Affinity DataIC50: 1.78E+4nMAssay Description:Inhibition of amyloid beta 40 secretion transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetMicrotubule-associated protein tau(Human)
University of Aveiro

Curated by ChEMBL
LigandPNGBDBM50601428(CHEMBL5175279)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of tau (unknown origin) transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetAmyloid-beta precursor protein(Human)
University of Aveiro

Curated by ChEMBL
LigandPNGBDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US9409845, Tab...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of amyloid beta 40 secretion transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetAmyloid-beta precursor protein(Human)
University of Aveiro

Curated by ChEMBL
LigandPNGBDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US9409845, Tab...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of amyloid beta 42 secretion transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetMicrotubule-associated protein tau(Human)
University of Aveiro

Curated by ChEMBL
LigandPNGBDBM50163748(4-(2-(5-(4-hydroxy-3-methoxystyryl)-1H-pyrazol-3-y...)
Affinity DataIC50: 3.40E+4nMAssay Description:Inhibition of tau (unknown origin) transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetMicrotubule-associated protein tau(Human)
University of Aveiro

Curated by ChEMBL
LigandPNGBDBM50601424(CHEMBL5209194)
Affinity DataIC50: 3.50E+4nMAssay Description:Inhibition of tau (unknown origin) transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetMicrotubule-associated protein tau(Human)
University of Aveiro

Curated by ChEMBL
LigandPNGBDBM50601427(CHEMBL5176644)
Affinity DataIC50: 3.50E+4nMAssay Description:Inhibition of tau (unknown origin) transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetAmyloid-beta precursor protein(Human)
University of Aveiro

Curated by ChEMBL
LigandPNGBDBM50601422(CHEMBL5174150)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of amyloid beta 42 secretion transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetAmyloid-beta precursor protein(Human)
University of Aveiro

Curated by ChEMBL
LigandPNGBDBM50601423(CHEMBL5195740)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of amyloid beta 42 secretion transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
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