42 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
PMID
Data
Article Title
Organization
2-Indolylmethylenebenzofuranones as first effective inhibitors of ABCC2.
Bmssi Umr 5086 Cnrs/Universit£
Mechanistic studies on the absorption and disposition of scutellarin in humans: selective OATP2B1-mediated hepatic uptake is a likely key determinant for its unique pharmacokinetic characteristics.
Chinese Academy of Sciences
In vitro investigations into the roles of drug transporters and metabolizing enzymes in the disposition and drug interactions of dolutegravir, a HIV integrase inhibitor.
Glaxosmithkline
Optimization of pyrrolamide topoisomerase II inhibitors toward identification of an antibacterial clinical candidate (AZD5099).
Astrazeneca
Potent nonimmunosuppressive cyclophilin inhibitors with improved pharmaceutical properties and decreased transporter inhibition.
Novartis Institutes For Biomedical Research
Biliary excretion of pravastatin in rats: contribution of the excretion pathway mediated by canalicular multispecific organic anion transporter.
Toho University School of Pharmaceutical Sciences
Methotrexate is excreted into the bile by canalicular multispecific organic anion transporter in rats.
Toho University School of Pharmaceutical Sciences
Hepatobiliary elimination of the peroxisome proliferator nafenopin by conjugation and subsequent ATP-dependent transport across the canalicular membrane.
Deutsches Krebsforschungszentrum
ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2.
Deutsches Krebsforschungszentrum
Are MDCK cells transfected with the human MRP2 gene a good model of the human intestinal mucosa?
The University of Kansas
Differential interaction of 3-hydroxy-3-methylglutaryl-coa reductase inhibitors with ABCB1, ABCC2, and OATP1B1.
Pfizer
Interaction of ivermectin with multidrug resistance proteins (MRP1, 2 and 3).
Laboratoire De Pharmacologie-Toxicologie Inra
Effect of multidrug resistance-reversing agents on transporting activity of human canalicular multispecific organic anion transporter.
Kagoshima University
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Uppsala University
Carrier-mediated mechanism for the biliary excretion of the quinolone antibiotic grepafloxacin and its glucuronide in rats.
University of Tokyo
Reduced folate derivatives are endogenous substrates for cMOAT in rats.
University of Tokyo
Temocaprilat, a novel angiotensin-converting enzyme inhibitor, is excreted in bile via an ATP-dependent active transporter (cMOAT) that is deficient in Eisai hyperbilirubinemic mutant rats (EHBR).
Sankyo
Primary active transport of peptidic endothelin antagonists by rat hepatic canalicular membrane.
University of Tokyo
Discovery of GS-9451: an acid inhibitor of the hepatitis C virus NS3/4A protease.
Gilead Sciences
Potent and selective inhibitors of breast cancer resistance protein (ABCG2) derived from the p-glycoprotein (ABCB1) modulator tariquidar.
University of Regensburg
A 4-aminobenzoic acid derivative as novel lead for selective inhibitors of multidrug resistance-associated proteins.
University of Bonn
Interaction potential of etravirine with drug transporters assessed in vitro.
University Hospital Heidelberg
Modulation of multidrug resistance protein 1 (MRP1/ABCC1)-mediated multidrug resistance by bivalent apigenin homodimers and their derivatives.
The Hong Kong Polytechnic University
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Uppsala University
Discovery and Optimization of Biaryl Alkyl Ethers as a Novel Class of Highly Selective, CNS-Penetrable, and Orally Active Adaptor Protein-2-Associated Kinase 1 (AAK1) Inhibitors for the Potential Treatment of Neuropathic Pain.
Bristol-Myers Squibb
Discovery of Encequidar, First-in-Class Intestine Specific P-glycoprotein Inhibitor.
Athenex
Pyxinol bearing amino acid residues: Easily achievable and promising modulators of P-glycoprotein-mediated multidrug resistance.
Universities of Shandong
Discovery and Early Clinical Development of an Inhibitor of 5-Lipoxygenase Activating Protein (AZD5718) for Treatment of Coronary Artery Disease.
TBA
Kinetic analysis of the primary active transport of conjugated metabolites across the bile canalicular membrane: comparative study of S-(2,4-dinitrophenyl)-glutathione and 6-hydroxy-5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)benzothiazole glucuronide.
University of Tokyo
Charged amino acids in the transmembrane domains are involved in the determination of the substrate specificity of rat Mrp2.
The University of Tokyo
Inhibition of transport across the hepatocyte canalicular membrane by the antibiotic fusidate.
Deutsches Krebsforschungszentrum
ATP-dependent para-aminohippurate transport by apical multidrug resistance protein MRP2.
Deutsches Krebsforschungszentrum
The potential for an interaction between MRP2 (ABCC2) and various therapeutic agents: probenecid as a candidate inhibitor of the biliary excretion of irinotecan metabolites.
University of Tokyo
Physicochemical parameters responsible for the affinity of methotrexate analogs for rat canalicular multispecific organic anion transporter (cMOAT/MRP2).
University of Tokyo
Carrier-mediated hepatobiliary transport of a novel antifolate, N-[4-[(2,4-dianninopteridine-6-yl)methyl]-3,4-dihydro-2H-1,4-benzothiazin-7-yl]carbonyl-L-homoglutamic acid, in rats.
University of Tokyo
Multispecific organic anion transporter is responsible for the biliary excretion of the camptothecin derivative irinotecan and its metabolites in rats.
University of Tokyo
Transport of monoglucuronosyl and bisglucuronosyl bilirubin by recombinant human and rat multidrug resistance protein 2.
Deutsches Krebsforschungszentrum
Design and optimization of 2,3-dihydrobenzo[b][1,4]dioxine propanoic acids as novel GPR40 agonists with improved pharmacokinetic and safety profiles.
Chinese Academy of Sciences
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Amgen
